SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		3 / 3 VAL A  98
VAL A 135
TRP A  92
 None
 0.90A 1av2C-2iqtA:
undetectable
1av2D-2iqtA:
undetectable		 1av2C-2iqtA:
4.12
1av2D-2iqtA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		4 / 7 SER A 237
ALA A 257
SER A 241
ALA A 262
 None
 1.07A 1k5qA-2iqtA:
undetectable
1k5qB-2iqtA:
undetectable		 1k5qA-2iqtA:
20.26
1k5qB-2iqtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		4 / 6 VAL A 287
GLU A 265
LEU A 263
PHE A 259
 None
 1.12A 1s8fB-2iqtA:
undetectable		 1s8fB-2iqtA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		3 / 3 VAL A  98
VAL A 135
TRP A  92
 None
 0.89A 1w5uC-2iqtA:
undetectable
1w5uD-2iqtA:
undetectable		 1w5uC-2iqtA:
4.12
1w5uD-2iqtA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		5 / 8 ARG A  10
ILE A 174
GLY A  70
ILE A  69
LEU A 231
 None
 1.46A 2o4nB-2iqtA:
undetectable		 2o4nB-2iqtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		3 / 3 LYS A 105
ARG A  79
LEU A 126
 None
 0.98A 3v4tE-2iqtA:
undetectable		 3v4tE-2iqtA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		4 / 8 LEU A 193
ILE A 152
ASN A 148
GLY A 113
 None
 0.88A 3wxoA-2iqtA:
undetectable		 3wxoA-2iqtA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		4 / 8 PHE A  15
ALA A 262
LEU A 263
GLY A  17
 None
 0.84A 4xk8a-2iqtA:
undetectable		 4xk8a-2iqtA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		4 / 6 LEU A 107
PRO A 119
PHE A 120
GLU A 122
 None
 1.25A 5b8iA-2iqtA:
undetectable		 5b8iA-2iqtA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		5 / 11 THR A  87
THR A  55
GLN A  52
GLY A  80
ASP A  48
 None
 1.35A 5bxnV-2iqtA:
undetectable
5bxnW-2iqtA:
undetectable		 5bxnV-2iqtA:
20.47
5bxnW-2iqtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		5 / 12 ASP A  20
GLN A  21
ILE A 174
VAL A  16
VAL A 234
 None
 1.11A 5dpdB-2iqtA:
undetectable		 5dpdB-2iqtA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1
(Porphyromonas
gingivalis) 		5 / 12 ILE A 155
LEU A 193
GLU A 110
GLY A 113
GLY A 151
 None
 1.09A 5l6eA-2iqtA:
undetectable		 5l6eA-2iqtA:
22.46