SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		3 / 3 ALA A 171
GLY A 108
SER A 176
 None
 0.38A 2ivuA-2iqxA:
undetectable		 2ivuA-2iqxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0H_B_ACHB1289_0
(FICOLIN-2)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 4 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 0.92A 2j0hB-2iqxA:
0.1		 2j0hB-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0H_C_ACHC1289_0
(FICOLIN-2)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 4 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 0.96A 2j0hC-2iqxA:
0.0		 2j0hC-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0H_F_ACHF1289_0
(FICOLIN-2)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 4 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 0.95A 2j0hF-2iqxA:
0.0		 2j0hF-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1289_1
(FICOLIN-2)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 4 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 0.98A 2j2pB-2iqxA:
0.0		 2j2pB-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1290_1
(FICOLIN-2)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 4 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 0.92A 2j2pC-2iqxA:
0.0		 2j2pC-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 6 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 1.02A 2j2pE-2iqxA:
undetectable
2j2pF-2iqxA:
undetectable		 2j2pE-2iqxA:
20.26
2j2pF-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1290_1
(FICOLIN-2)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 4 ARG A  26
ASP A  35
THR A  33
LYS A   2
 None
 0.90A 2j2pF-2iqxA:
0.0		 2j2pF-2iqxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 7 GLY A  61
PRO A  60
GLY A  94
TYR A  64
 None
 0.87A 2jklD-2iqxA:
undetectable		 2jklD-2iqxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		3 / 3 PRO A 130
LEU A 131
GLN A 127
 None
 0.60A 3hznG-2iqxA:
undetectable
3hznH-2iqxA:
undetectable		 3hznG-2iqxA:
23.63
3hznH-2iqxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 8 GLY A 147
THR A  69
LEU A  88
PHE A 149
 None
 1.24A 4m5mA-2iqxA:
undetectable		 4m5mA-2iqxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 8 VAL A 124
VAL A  89
TYR A  64
LEU A  58
 None
 1.03A 4puoC-2iqxA:
undetectable		 4puoC-2iqxA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 7 GLU A 128
TYR A 125
GLU A 126
ARG A 155
 None
 1.21A 4r87J-2iqxA:
undetectable
4r87L-2iqxA:
undetectable		 4r87J-2iqxA:
21.89
4r87L-2iqxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 6 ASN A  91
GLU A 135
TYR A 158
PHE A 154
 None
 0.98A 4twdB-2iqxA:
undetectable
4twdC-2iqxA:
undetectable		 4twdB-2iqxA:
19.74
4twdC-2iqxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 5 ASN A  91
GLU A 135
TYR A 158
PHE A 154
 None
 1.06A 4twdC-2iqxA:
0.0
4twdD-2iqxA:
0.0		 4twdC-2iqxA:
19.74
4twdD-2iqxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 6 ASN A  91
GLU A 135
TYR A 158
PHE A 154
 None
 1.02A 4twdD-2iqxA:
undetectable
4twdE-2iqxA:
undetectable		 4twdD-2iqxA:
19.74
4twdE-2iqxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 6 ASN A  91
GLU A 135
TYR A 158
PHE A 154
 None
 1.03A 4twdG-2iqxA:
undetectable
4twdH-2iqxA:
undetectable		 4twdG-2iqxA:
19.74
4twdH-2iqxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 9 ILE A 137
VAL A  90
ASN A 132
ASP A 134
 None
 1.04A 5lg3I-2iqxA:
undetectable		 5lg3I-2iqxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 6 ALA A 171
LEU A  41
TYR A  29
SER A 109
 None
 1.07A 5phhA-2iqxA:
undetectable		 5phhA-2iqxA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2iqx PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
1
(Rattus
norvegicus) 		4 / 6 ASP A 134
LEU A  88
SER A 104
PHE A 149
 None
 1.09A 6ekuA-2iqxA:
undetectable		 6ekuA-2iqxA:
13.74