SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2irm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 12 LEU A  86
LEU A  87
GLY A  88
GLN A  89
ILE A  54
 None
 1.21A 1p93A-2irmA:
undetectable		 1p93A-2irmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 8 ALA A 169
ILE A 271
GLY A 270
GLY A 269
ILE A 267
 None
 1.13A 1sguA-2irmA:
undetectable		 1sguA-2irmA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 7 LEU A 178
LEU A 282
PHE A 107
SER A 164
 None
 0.88A 1wrlE-2irmA:
undetectable
1wrlF-2irmA:
undetectable		 1wrlE-2irmA:
15.56
1wrlF-2irmA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 8 LEU A  85
ILE A 103
LEU A 170
THR A  59
LEU A  90
 None
 1.29A 2xfhA-2irmA:
undetectable		 2xfhA-2irmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 12 TYR A 177
SER A  55
ASN A  58
VAL A  99
LEU A 102
 None
 1.14A 3cb8A-2irmA:
0.2		 3cb8A-2irmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 8 MET A 309
ILE A 294
VAL A 357
MET A 283
 None
 1.30A 4f4dB-2irmA:
undetectable		 4f4dB-2irmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 8 LEU A 197
VAL A 307
VAL A 323
ILE A 361
 None
 0.94A 4l4cB-2irmA:
undetectable		 4l4cB-2irmA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 12 LEU A  61
ILE A 103
GLY A 179
LEU A 280
LEU A 188
 None
 0.99A 4o1zA-2irmA:
0.0		 4o1zA-2irmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 5 HIS A 206
ILE A 181
SER A 203
ALA A 166
 None
 1.28A 5msdA-2irmA:
undetectable		 5msdA-2irmA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 12 LEU A 282
MET A 283
LEU A 359
LEU A 306
LEU A 188
 None
 1.10A 5toaB-2irmA:
undetectable		 5toaB-2irmA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 7 GLY A  27
LEU A 359
ILE A 361
GLY A  25
LEU A 320
 None
 1.19A 5vkqA-2irmA:
undetectable
5vkqB-2irmA:
undetectable		 5vkqA-2irmA:
12.79
5vkqB-2irmA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 8 ILE A 273
PHE A 279
ALA A 186
LEU A 282
 None
 0.87A 5y7pC-2irmA:
undetectable		 5y7pC-2irmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 8 ILE A 273
PHE A 279
ALA A 186
LEU A 282
 None
 0.83A 5y7pE-2irmA:
undetectable		 5y7pE-2irmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 6 PHE A 227
VAL A 261
LEU A 220
LEU A 222
 None
 0.95A 6e43A-2irmA:
undetectable		 6e43A-2irmA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 6 PHE A 227
VAL A 261
LEU A 220
LEU A 222
 None
 0.94A 6e43B-2irmA:
undetectable		 6e43B-2irmA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 6 PHE A 227
VAL A 261
LEU A 220
LEU A 222
 None
 0.97A 6e43C-2irmA:
undetectable		 6e43C-2irmA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		4 / 6 PHE A 227
VAL A 261
LEU A 220
LEU A 222
 None
 0.92A 6e43D-2irmA:
undetectable		 6e43D-2irmA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1
(Anopheles
gambiae) 		5 / 12 LEU A 170
LEU A  87
GLY A  88
ASN A  91
ALA A  82
 None
 1.27A 6r2eH-2irmA:
undetectable		 6r2eH-2irmA:
18.55