SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2irp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXY_A_SAMA6734_0 (N-LYSINE METHYLTRANSFERASE SETD6)	2irp	PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979 (Aquifex aeolicus)	5 / 12	ALA A 186 GLY A 180 TYR A 88 HIS A 99 LEU A 176	None	1.17A	3qxyA-2irpA: undetectable	3qxyA-2irpA: 17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RC0_B_SAMB480_0 (N-LYSINE METHYLTRANSFERASE SETD6)	2irp	PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979 (Aquifex aeolicus)	5 / 12	ALA A 186 GLY A 180 TYR A 88 HIS A 99 LEU A 176	None	1.20A	3rc0B-2irpA: undetectable	3rc0B-2irpA: 17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRX_A_H8GA1201_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2irp	PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979 (Aquifex aeolicus)	5 / 12	VAL A 98 SER A 37 ALA A 19 VAL A 94 TYR A 88	None	1.33A	6drxA-2irpA: undetectable	6drxA-2irpA: 18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRY_A_H8DA2001_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2irp	PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979 (Aquifex aeolicus)	5 / 11	VAL A 98 SER A 37 ALA A 19 VAL A 94 TYR A 88	None	1.36A	6dryA-2irpA: undetectable	6dryA-2irpA: 18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLO_A_GBQA1501_1 (SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR)	2irp	PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979 (Aquifex aeolicus)	5 / 9	ILE A 36 ILE A 47 TRP A 28 GLU A 194 VAL A 98	None	1.39A	6hloA-2irpA: undetectable	6hloA-2irpA: 18.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3QXY_A_SAMA6734_0","N-LYSINE METHYLTRANSFERASE SETD6","2irp","PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979","Aquifex aeolicus",5,"ALA A 186;GLY A 180;TYR A  88;HIS A  99;LEU A 176","None","1.17A","3qxyA-2irpA:undetectable","3qxyA-2irpA:17.47"],["3RC0_B_SAMB480_0","N-LYSINE METHYLTRANSFERASE SETD6","2irp","PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979","Aquifex aeolicus",5,"ALA A 186;GLY A 180;TYR A  88;HIS A  99;LEU A 176","None","1.20A","3rc0B-2irpA:undetectable","3rc0B-2irpA:17.47"],["6DRX_A_H8GA1201_0","5HT2B RECEPTOR, BRIL CHIMERA","2irp","PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979","Aquifex aeolicus",5,"VAL A  98;SER A  37;ALA A  19;VAL A  94;TYR A  88","None","1.33A","6drxA-2irpA:undetectable","6drxA-2irpA:18.10"],["6DRY_A_H8DA2001_0","5HT2B RECEPTOR, BRIL CHIMERA","2irp","PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979","Aquifex aeolicus",5,"VAL A  98;SER A  37;ALA A  19;VAL A  94;TYR A  88","None","1.36A","6dryA-2irpA:undetectable","6dryA-2irpA:18.05"],["6HLO_A_GBQA1501_1","SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR","2irp","PUTATIVE ALDOLASE CLASS 2 PROTEIN AQ_1979","Aquifex aeolicus",5,"ILE A  36;ILE A  47;TRP A  28;GLU A 194;VAL A  98","None","1.39A","6hloA-2irpA:undetectable","6hloA-2irpA:18.13"]]