SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2is3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		3 / 3 GLU A  38
HIS A  61
HIS A  59
 None
 0.58A 1oe2A-2is3A:
undetectable		 1oe2A-2is3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		3 / 3 ASP A  23
PHE A 128
ASN A 121
 None
 0.64A 1sg9B-2is3A:
undetectable		 1sg9B-2is3A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		3 / 3 ASP A 125
ASP A 150
ASP A 186
 None
 0.72A 2igtA-2is3A:
undetectable		 2igtA-2is3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		3 / 3 ASP A 125
ASP A 150
ASP A 186
 None
 0.73A 2igtB-2is3A:
undetectable		 2igtB-2is3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		3 / 3 GLY A  67
PRO A  64
LEU A  70
 None
 0.62A 3hcpB-2is3A:
undetectable		 3hcpB-2is3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		4 / 6 PHE A 128
THR A  33
ALA A 132
ALA A 131
 None
 1.22A 3ns1C-2is3A:
undetectable		 3ns1C-2is3A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		5 / 8 LYS A 166
ALA A 167
GLY A 160
LEU A 159
LEU A 193
 None
 1.29A 4po0A-2is3A:
undetectable		 4po0A-2is3A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		4 / 5 THR A 190
ASP A 125
GLU A  25
ASN A  78
 None
 1.41A 5ybbA-2is3A:
undetectable		 5ybbA-2is3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		3 / 3 GLU A 196
LEU A 193
ARG A 189
 None
None
SO4  A 217 (-3.5A)
 0.79A 6d8fA-2is3A:
undetectable		 6d8fA-2is3A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2is3 RIBONUCLEASE T
(Escherichia
coli) 		5 / 10 VAL A  24
VAL A  62
ILE A  99
ALA A  95
ALA A 136
 None
 1.14A 6h1lA-2is3A:
undetectable		 6h1lA-2is3A:
20.18