SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2is5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	5 / 12	GLY A 18 ILE A 34 VAL A 86 LEU A 13 PHE A 82	None	1.13A	2zzmA-2is5A: undetectable	2zzmA-2is5A: 18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TX2_A_BEZA251_0 (PROBABLE 6-PHOSPHOGLUCONOLACT ONASE)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	4 / 7	ALA A 84 TRP A 150 MET A 96 ALA A 93	None	1.40A	3tx2A-2is5A: undetectable	3tx2A-2is5A: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWP_B_GCSB307_1 (CHITOSANASE)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	4 / 7	THR A 30 GLY A 33 THR A 35 VAL A 86	None	0.81A	4qwpB-2is5A: 8.4	4qwpB-2is5A: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QYQ_C_3CJC607_1 (LACTOPEROXIDASE)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	4 / 6	GLN A 80 ASP A 83 ARG A 133 ARG A 153	None	1.10A	4qyqC-2is5A: undetectable	4qyqC-2is5A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HPW_C_3CJC609_1 (LACTOPEROXIDASE)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	4 / 6	GLN A 80 ASP A 83 ARG A 133 ARG A 153	None	1.10A	5hpwC-2is5A: undetectable	5hpwC-2is5A: 16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHB_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	3 / 3	PHE A 79 ASP A 83 LEU A 127	None	0.56A	5uhbC-2is5A: undetectable	5uhbC-2is5A: 10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHC_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	3 / 3	PHE A 79 ASP A 83 LEU A 127	None	0.43A	5uhcC-2is5A: undetectable	5uhcC-2is5A: 10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BRD_B_RFPB502_2 (RIFAMPIN MONOOXYGENASE)	2is5	HYPOTHETICAL PROTEIN (Neisseria meningitidis)	4 / 6	GLN A 80 VAL A 12 LEU A 125 PRO A 74	None	1.06A	6brdB-2is5A: undetectable	6brdB-2is5A: 18.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZZM_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",5,"GLY A  18;ILE A  34;VAL A  86;LEU A  13;PHE A  82","None","1.13A","2zzmA-2is5A:undetectable","2zzmA-2is5A:18.34"],["3TX2_A_BEZA251_0","PROBABLE 6-PHOSPHOGLUCONOLACTONASE","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",4,"ALA A  84;TRP A 150;MET A  96;ALA A  93","None","1.40A","3tx2A-2is5A:undetectable","3tx2A-2is5A:21.03"],["4QWP_B_GCSB307_1","CHITOSANASE","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",4,"THR A  30;GLY A  33;THR A  35;VAL A  86","None","0.81A","4qwpB-2is5A:8.4","4qwpB-2is5A:24.23"],["4QYQ_C_3CJC607_1","LACTOPEROXIDASE","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",4,"GLN A  80;ASP A  83;ARG A 133;ARG A 153","None","1.10A","4qyqC-2is5A:undetectable","4qyqC-2is5A:16.21"],["5HPW_C_3CJC609_1","LACTOPEROXIDASE","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",4,"GLN A  80;ASP A  83;ARG A 133;ARG A 153","None","1.10A","5hpwC-2is5A:undetectable","5hpwC-2is5A:16.21"],["5UHB_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",3,"PHE A  79;ASP A  83;LEU A 127","None","0.56A","5uhbC-2is5A:undetectable","5uhbC-2is5A:10.17"],["5UHC_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",3,"PHE A  79;ASP A  83;LEU A 127","None","0.43A","5uhcC-2is5A:undetectable","5uhcC-2is5A:10.17"],["6BRD_B_RFPB502_2","RIFAMPIN MONOOXYGENASE","2is5","HYPOTHETICAL PROTEIN","Neisseria meningitidis",4,"GLN A  80;VAL A  12;LEU A 125;PRO A  74","None","1.06A","6brdB-2is5A:undetectable","6brdB-2is5A:18.07"]]