SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2is8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 12 ILE A 125
ALA A 117
MET A  99
LEU A 146
ILE A  26
 None
 1.18A 1rx3A-2is8A:
undetectable		 1rx3A-2is8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 12 GLY A 130
GLN A  19
ASP A  20
HIS A  23
ARG A 136
 None
None
FMT  A1003 (-3.7A)
None
None
 1.18A 1wg8A-2is8A:
2.8		 1wg8A-2is8A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		4 / 7 LEU A 124
PHE A   2
LEU A  95
PHE A  35
 None
 1.02A 1wrlE-2is8A:
undetectable
1wrlF-2is8A:
undetectable		 1wrlE-2is8A:
21.83
1wrlF-2is8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 11 ALA A 149
LEU A 128
LEU A  67
LEU A 146
LEU A 126
 None
 1.11A 2ceoA-2is8A:
undetectable		 2ceoA-2is8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 12 LEU A  95
LEU A 126
ARG A  90
VAL A   4
VAL A 153
 None
 1.26A 2qd4A-2is8A:
6.1		 2qd4A-2is8A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 10 ALA A 149
LEU A 128
LEU A  67
LEU A 146
LEU A 126
 None
 1.20A 2riwA-2is8A:
2.3
2riwB-2is8A:
undetectable		 2riwA-2is8A:
18.86
2riwB-2is8A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 10 ALA A 149
LEU A 128
LEU A  67
LEU A 146
LEU A 126
 None
 1.10A 2xn6A-2is8A:
undetectable
2xn6B-2is8A:
undetectable		 2xn6A-2is8A:
19.12
2xn6B-2is8A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 10 ALA A 149
LEU A 128
LEU A  67
LEU A 146
LEU A 126
 None
 1.15A 2xn7A-2is8A:
undetectable
2xn7B-2is8A:
undetectable		 2xn7A-2is8A:
19.12
2xn7B-2is8A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		3 / 3 ASP A  11
ARG A  15
ARG A  79
 None
 0.71A 3k37A-2is8A:
undetectable		 3k37A-2is8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 12 ILE A  26
LEU A 139
VAL A 142
LEU A  65
ALA A 149
 None
 1.20A 3ozuA-2is8A:
undetectable		 3ozuA-2is8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		4 / 8 ILE A  50
LEU A  54
VAL A 116
GLY A 115
 None
 0.79A 3w1wA-2is8A:
6.2		 3w1wA-2is8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		4 / 7 THR A  68
LEU A  87
VAL A  43
VAL A   9
 None
 0.99A 4cp4A-2is8A:
undetectable		 4cp4A-2is8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		5 / 12 ILE A 125
ALA A 117
MET A  99
LEU A 146
ILE A  26
 None
 1.27A 4gh8B-2is8A:
undetectable		 4gh8B-2is8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		3 / 3 ASP A  20
ARG A 136
THR A   8
 FMT  A1003 (-3.7A)
None
FMT  A1003 (-4.1A)
 0.71A 4i13A-2is8A:
undetectable		 4i13A-2is8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		4 / 4 ILE A  26
ASP A  20
ARG A 136
THR A   8
 None
FMT  A1003 (-3.7A)
None
FMT  A1003 (-4.1A)
 1.20A 4nx6A-2is8A:
undetectable		 4nx6A-2is8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		4 / 4 ILE A  26
ASP A  20
ARG A 136
THR A   8
 None
FMT  A1003 (-3.7A)
None
FMT  A1003 (-4.1A)
 1.20A 4nx7A-2is8A:
undetectable		 4nx7A-2is8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		3 / 3 ASP A  20
ARG A 136
THR A   8
 FMT  A1003 (-3.7A)
None
FMT  A1003 (-4.1A)
 0.72A 4p3rA-2is8A:
undetectable		 4p3rA-2is8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		3 / 3 ILE A  26
ASP A  20
ARG A 136
 None
FMT  A1003 (-3.7A)
None
 0.84A 4pstA-2is8A:
undetectable		 4pstA-2is8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		6 / 12 GLY A  70
ASP A  20
ILE A   6
ALA A 135
GLY A 134
ILE A  26
 None
FMT  A1003 (-3.7A)
None
None
None
None
 1.31A 5kb6A-2is8A:
undetectable		 5kb6A-2is8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		6 / 12 GLY A  70
ASP A  20
ILE A   6
ALA A 135
GLY A 134
ILE A  26
 None
FMT  A1003 (-3.7A)
None
None
None
None
 1.29A 5kb6B-2is8A:
undetectable		 5kb6B-2is8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB
(Thermus
thermophilus) 		4 / 8 GLY A 115
GLY A 134
SER A 138
ALA A 141
 None
 0.76A 6hu9H-2is8A:
undetectable
6hu9e-2is8A:
undetectable		 6hu9H-2is8A:
18.06
6hu9e-2is8A:
21.38