SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2isa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 VAL A 175
MET A 179
VAL A 448
ILE A 471
 None
 0.98A 1e06A-2isaA:
4.6		 1e06A-2isaA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 5 PHE A 438
GLY A 468
THR A 176
PHE A 426
 None
 1.26A 1icuC-2isaA:
undetectable
1icuD-2isaA:
undetectable		 1icuC-2isaA:
17.77
1icuD-2isaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 5 PHE A 438
GLY A 468
THR A 176
PHE A 426
 None
 1.26A 1icvA-2isaA:
undetectable
1icvB-2isaA:
undetectable		 1icvA-2isaA:
17.77
1icvB-2isaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 THR A 176
PHE A 426
PHE A 438
GLY A 468
 None
 1.05A 1kqbA-2isaA:
undetectable
1kqbB-2isaA:
undetectable		 1kqbA-2isaA:
19.05
1kqbB-2isaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 THR A 176
PHE A 426
PHE A 438
GLY A 468
 None
 1.10A 1kqbC-2isaA:
undetectable
1kqbD-2isaA:
undetectable		 1kqbC-2isaA:
19.05
1kqbD-2isaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 PHE A 438
GLY A 468
THR A 176
PHE A 426
 None
 1.16A 1kqbC-2isaA:
undetectable
1kqbD-2isaA:
undetectable		 1kqbC-2isaA:
19.05
1kqbD-2isaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2isa CATALASE
(Aliivibrio
salmonicida) 		3 / 3 ARG A 333
VAL A 211
GLY A 321
 HEM  A 486 (-3.5A)
None
None
 0.52A 2avvE-2isaA:
undetectable		 2avvE-2isaA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		3 / 3 ASN A 127
TYR A 337
SER A 112
 HEM  A 486 (-3.4A)
HEM  A 486 (-4.1A)
HEM  A 486 ( 3.8A)
 0.92A 2gvcB-2isaA:
undetectable		 2gvcB-2isaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		3 / 3 ASN A 127
TYR A 337
SER A 112
 HEM  A 486 (-3.4A)
HEM  A 486 (-4.1A)
HEM  A 486 ( 3.8A)
 0.90A 2gvcE-2isaA:
undetectable		 2gvcE-2isaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 LEU A 437
ASN A 161
GLN A 453
ILE A 471
 None
 1.17A 2jn3A-2isaA:
1.0		 2jn3A-2isaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 7 ALA A 336
ALA A 340
PRO A 315
ARG A  51
 HEM  A 486 ( 3.8A)
HEM  A 486 ( 3.7A)
None
HEM  A 486 (-4.1A)
 1.00A 2ql8A-2isaA:
undetectable
2ql8B-2isaA:
undetectable		 2ql8A-2isaA:
14.93
2ql8B-2isaA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 7 GLY A  62
MET A  88
GLN A 219
PHE A  92
 None
 0.95A 2qwxA-2isaA:
undetectable
2qwxB-2isaA:
undetectable		 2qwxA-2isaA:
20.41
2qwxB-2isaA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		5 / 12 HIS A 456
GLY A 470
GLY A 468
LEU A 437
LEU A 474
 None
 1.16A 3cjtG-2isaA:
undetectable		 3cjtG-2isaA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		5 / 11 ARG A 242
LEU A 245
ASP A 103
SER A  58
GLY A 100
 None
 0.97A 3sfuC-2isaA:
undetectable		 3sfuC-2isaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 5 LEU A 330
PHE A 324
PRO A 315
ALA A 316
 None
None
None
GOL  A5489 (-3.4A)
 1.37A 3vm4A-2isaA:
undetectable		 3vm4A-2isaA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2isa CATALASE
(Aliivibrio
salmonicida) 		5 / 12 PRO A 275
PHE A 276
PRO A 326
LEU A 401
ALA A 269
 None
 1.34A 4a84A-2isaA:
1.3		 4a84A-2isaA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2isa CATALASE
(Aliivibrio
salmonicida) 		3 / 3 LYS A  56
THR A  94
ILE A 184
 None
 0.76A 4e0fB-2isaA:
undetectable		 4e0fB-2isaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2isa CATALASE
(Aliivibrio
salmonicida) 		3 / 3 ARG A  99
TYR A 337
ASN A 355
 None
HEM  A 486 (-4.1A)
None
 0.73A 4ffwB-2isaA:
undetectable		 4ffwB-2isaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 9 TYR A 337
LYS A  54
HIS A  54
PHE A 140
 HEM  A 486 (-4.1A)
OMT  A  53 (-3.0A)
HEM  A 486 (-3.4A)
HEM  A 486 (-3.4A)
 1.35A 4jvlA-2isaA:
undetectable		 4jvlA-2isaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 GLY A 126
ASP A 123
PRO A 315
ARG A 333
 HEM  A 486 (-4.1A)
None
None
HEM  A 486 (-3.5A)
 1.09A 4lajA-2isaA:
undetectable
4lajB-2isaA:
undetectable		 4lajA-2isaA:
20.29
4lajB-2isaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 GLY A 195
ASP A 123
PRO A 315
ARG A 333
 None
None
None
HEM  A 486 (-3.5A)
 0.99A 4lajA-2isaA:
undetectable
4lajB-2isaA:
undetectable		 4lajA-2isaA:
20.29
4lajB-2isaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		5 / 12 LEU A 297
GLY A 110
ASN A 127
ALA A  90
GLY A 195
 None
HEM  A 486 (-3.6A)
HEM  A 486 (-3.4A)
None
None
 1.17A 4n09A-2isaA:
undetectable		 4n09A-2isaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 4 ASN A 298
GLY A  62
ASP A  81
ASP A  87
 None
 1.13A 4n49A-2isaA:
undetectable		 4n49A-2isaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 7 ALA A 466
ILE A 471
LEU A 437
PHE A 438
 None
 1.00A 4uymA-2isaA:
undetectable		 4uymA-2isaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 7 MET A 191
HIS A  54
GLY A 126
ASN A 127
 None
HEM  A 486 (-3.4A)
HEM  A 486 (-4.1A)
HEM  A 486 (-3.4A)
 1.36A 5a5zC-2isaA:
undetectable		 5a5zC-2isaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 5 PHE A  92
SER A  93
ASN A 223
ASP A 181
 None
HEM  A 486 ( 4.4A)
None
None
 1.45A 5kpcA-2isaA:
undetectable		 5kpcA-2isaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2isa CATALASE
(Aliivibrio
salmonicida) 		4 / 6 LEU A 168
SER A 167
PHE A 164
ASP A 163
 None
 1.06A 5om3A-2isaA:
undetectable
5om3B-2isaA:
undetectable		 5om3A-2isaA:
12.05
5om3B-2isaA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		3 / 3 HIS A 362
SER A 363
ARG A 366
 None
 0.93A 5u63A-2isaA:
undetectable		 5u63A-2isaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2isa CATALASE
(Aliivibrio
salmonicida) 		5 / 9 ASP A 103
SER A 239
TYR A 188
GLY A 220
ILE A 221
 None
 1.47A 6giqA-2isaA:
0.0
6giqE-2isaA:
undetectable
6giqI-2isaA:
undetectable		 6giqA-2isaA:
23.50
6giqE-2isaA:
18.55
6giqI-2isaA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2isa CATALASE
(Aliivibrio
salmonicida) 		3 / 3 ASP A 236
LEU A 232
ARG A 109
 None
 0.86A 7dfrA-2isaA:
undetectable		 7dfrA-2isaA:
16.60