SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2isb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isb FUMARASE
(Archaeoglobus
fulgidus) 		3 / 3 VAL A 155
ALA A  34
HIS A  63
 None
 0.75A 1q23C-2isbA:
undetectable		 1q23C-2isbA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isb FUMARASE
(Archaeoglobus
fulgidus) 		3 / 3 VAL A 155
ALA A  34
HIS A  63
 None
 0.75A 1q23H-2isbA:
undetectable		 1q23H-2isbA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2isb FUMARASE
(Archaeoglobus
fulgidus) 		4 / 4 GLY A 107
SER A  84
ILE A 103
HIS A  63
 None
 1.31A 1yajJ-2isbA:
undetectable		 1yajJ-2isbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2isb FUMARASE
(Archaeoglobus
fulgidus) 		4 / 4 GLY A 108
SER A  84
ILE A 103
HIS A  63
 None
 1.25A 1yajJ-2isbA:
undetectable		 1yajJ-2isbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2isb FUMARASE
(Archaeoglobus
fulgidus) 		4 / 5 PHE A 163
ILE A 138
GLY A  80
CYH A  64
 None
 1.24A 3r0lD-2isbA:
undetectable		 3r0lD-2isbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2isb FUMARASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  95
VAL A  98
ALA A  42
PHE A  32
PHE A  54
 None
 1.39A 4iaqA-2isbA:
undetectable		 4iaqA-2isbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2isb FUMARASE
(Archaeoglobus
fulgidus) 		5 / 12 PRO A  92
THR A  91
HIS A  63
PHE A  56
GLY A 102
 None
 1.39A 4ydqB-2isbA:
undetectable		 4ydqB-2isbA:
16.13