SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2isj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2isj BLUB
(Sinorhizobium
meliloti) 		5 / 10 CYH A 191
LEU A 190
ILE A 174
PHE A  37
ILE A 111
 None
 1.10A 1i18A-2isjA:
undetectable
1i18B-2isjA:
undetectable		 1i18A-2isjA:
24.44
1i18B-2isjA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2isj BLUB
(Sinorhizobium
meliloti) 		5 / 10 PHE A  37
ILE A 111
CYH A 191
LEU A 190
ILE A 174
 None
 1.07A 1i18A-2isjA:
undetectable
1i18B-2isjA:
undetectable		 1i18A-2isjA:
24.44
1i18B-2isjA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isj BLUB
(Sinorhizobium
meliloti) 		3 / 3 VAL A 149
ALA A 148
HIS A  55
 None
 0.60A 1q23C-2isjA:
undetectable		 1q23C-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isj BLUB
(Sinorhizobium
meliloti) 		3 / 3 VAL A 149
ALA A 148
HIS A  55
 None
 0.54A 1q23H-2isjA:
undetectable		 1q23H-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isj BLUB
(Sinorhizobium
meliloti) 		3 / 3 VAL A 149
ALA A 148
HIS A  55
 None
 0.49A 1q23G-2isjA:
undetectable		 1q23G-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isj BLUB
(Sinorhizobium
meliloti) 		3 / 3 VAL A 149
ALA A 148
HIS A  55
 None
 0.76A 1q23L-2isjA:
undetectable		 1q23L-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isj BLUB
(Sinorhizobium
meliloti) 		3 / 3 VAL A 149
ALA A 148
HIS A  55
 None
 0.45A 1q23J-2isjA:
undetectable		 1q23J-2isjA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2isj BLUB
(Sinorhizobium
meliloti) 		5 / 10 ILE A 168
ALA A  91
ARG A 104
ALA A  92
ILE A 111
 FMN  A 502 (-4.5A)
None
None
None
None
 1.12A 2aclC-2isjA:
undetectable		 2aclC-2isjA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2isj BLUB
(Sinorhizobium
meliloti) 		4 / 8 ARG A  72
TRP A 189
ILE A  47
GLY A 193
 None
 0.71A 2gssA-2isjA:
undetectable		 2gssA-2isjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2isj BLUB
(Sinorhizobium
meliloti) 		4 / 8 ARG A  72
TRP A 189
ILE A  47
GLY A 193
 None
 0.72A 2gssB-2isjA:
undetectable		 2gssB-2isjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2isj BLUB
(Sinorhizobium
meliloti) 		5 / 12 ILE A 168
ALA A  91
ARG A 104
ALA A  92
ILE A 111
 FMN  A 502 (-4.5A)
None
None
None
None
 0.90A 3e00A-2isjA:
undetectable		 3e00A-2isjA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2isj BLUB
(Sinorhizobium
meliloti) 		5 / 11 GLU A  44
LEU A  70
ARG A  72
GLY A  52
HIS A  55
 None
 1.38A 3hm1B-2isjA:
undetectable		 3hm1B-2isjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2isj BLUB
(Sinorhizobium
meliloti) 		4 / 8 ARG A  72
TRP A 189
ILE A  47
GLY A 193
 None
 0.75A 3n9jA-2isjA:
undetectable		 3n9jA-2isjA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 2isj BLUB
(Sinorhizobium
meliloti) 		3 / 3 ARG A 124
LYS A 175
ARG A 134
 None
 1.43A 6az3C-2isjA:
undetectable
6az3L-2isjA:
undetectable
6az3M-2isjA:
0.0		 6az3C-2isjA:
15.65
6az3L-2isjA:
10.86
6az3M-2isjA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2isj BLUB
(Sinorhizobium
meliloti) 		4 / 7 TRP A  66
ARG A 124
HIS A 183
ASP A 141
 None
 1.14A 6mn4E-2isjA:
undetectable		 6mn4E-2isjA:
22.39