SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ism'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 6 LEU A  45
ALA A  65
LEU A  55
SER A  62
 None
 1.05A 1ictB-2ismA:
undetectable		 1ictB-2ismA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		3 / 3 ARG A 139
GLY A 271
PRO A 270
 None
 0.74A 2hreD-2ismA:
undetectable		 2hreD-2ismA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 6 ARG A 318
GLN A 205
ASN A 203
LEU A 216
 CL  A1003 (-3.1A)
CL  A1003 (-3.1A)
None
None
 1.20A 2nyrA-2ismA:
undetectable		 2nyrA-2ismA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 5 LEU A  80
ARG A 139
ALA A  37
ILE A 140
 None
 1.07A 2qhfA-2ismA:
undetectable		 2qhfA-2ismA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 10 ILE A  53
TYR A  93
PRO A  90
LEU A 110
TYR A  64
 None
 1.47A 2ze2A-2ismA:
0.5		 2ze2A-2ismA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A 351
LEU A  21
ALA A 274
ALA A 310
PHE A 268
 None
 1.28A 3b0wA-2ismA:
undetectable		 3b0wA-2ismA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 4 GLU A 195
GLY A 178
THR A 175
GLU A 177
 None
 0.99A 3e9xA-2ismA:
undetectable		 3e9xA-2ismA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 8 VAL A 107
LEU A 124
ILE A 140
VAL A 150
LEU A 172
 None
 1.32A 3kp6A-2ismA:
undetectable
3kp6B-2ismA:
undetectable		 3kp6A-2ismA:
16.48
3kp6B-2ismA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  61
ILE A  46
ALA A  47
ALA A  65
THR A  63
 None
 0.98A 3mdvB-2ismA:
undetectable		 3mdvB-2ismA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		3 / 3 ARG A 173
TRP A 209
GLY A 143
 None
 0.84A 4e7cA-2ismA:
undetectable		 4e7cA-2ismA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 8 SER A 218
LEU A 285
ALA A 283
SER A 219
 None
 0.95A 4ikjA-2ismA:
undetectable
4ikjB-2ismA:
undetectable		 4ikjA-2ismA:
16.02
4ikjB-2ismA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 8 LEU A 285
ALA A 283
SER A 219
SER A 218
 None
 0.96A 4ikkA-2ismA:
undetectable
4ikkB-2ismA:
undetectable		 4ikkA-2ismA:
16.02
4ikkB-2ismA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 5 ALA A  47
ARG A 139
ALA A  37
GLU A 319
 None
 1.46A 5a06C-2ismA:
undetectable
5a06D-2ismA:
undetectable		 5a06C-2ismA:
23.76
5a06D-2ismA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		5 / 9 VAL A  23
GLY A  28
VAL A  27
ASP A 345
GLY A 344
 None
 1.40A 5zniA-2ismA:
undetectable		 5zniA-2ismA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 2ism PUTATIVE
OXIDOREDUCTASE
(Thermus
thermophilus) 		4 / 8 TRP A  34
LEU A 207
GLU A 319
THR A 151
 None
 1.15A 6c71B-2ismA:
undetectable		 6c71B-2ismA:
13.64