SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2isn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		3 / 3 ASP A 286
ILE A 188
VAL A 327
 None
 0.58A 2avvD-2isnA:
undetectable		 2avvD-2isnA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		6 / 12 SER A 103
SER A 183
THR A  15
VAL A 108
ALA A 177
VAL A  80
 None
 1.21A 2nniA-2isnA:
undetectable		 2nniA-2isnA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 8 TYR A 265
GLN A 263
ILE A 126
SER A 172
 None
 1.12A 2xytE-2isnA:
undetectable		 2xytE-2isnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 7 TYR A 265
GLN A 263
ILE A 126
SER A 172
 None
 1.16A 2xytI-2isnA:
undetectable		 2xytI-2isnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 GLY A  51
GLU A  28
ARG A  24
ALA A  30
ASP A 277
 None
None
None
None
PR  A 522 (-2.5A)
 1.15A 3ckkA-2isnA:
undetectable		 3ckkA-2isnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		5 / 9 GLN A  59
ALA A  30
SER A 103
LEU A  87
ILE A  91
 None
 1.32A 3claA-2isnA:
undetectable		 3claA-2isnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 HIS A 201
PHE A  49
GLY A 105
GLY A 181
ILE A 178
 None
 1.18A 3fzgA-2isnA:
undetectable		 3fzgA-2isnA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		3 / 3 LYS A  81
ARG A 235
LYS A 135
 None
 1.21A 3okxA-2isnA:
undetectable		 3okxA-2isnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 7 GLU A 146
ILE A 142
HIS A 189
VAL A 295
 None
 0.99A 4a97A-2isnA:
undetectable		 4a97A-2isnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 7 ASP A  29
GLY A 105
SER A 326
THR A  19
 None
 1.00A 4ac9C-2isnA:
undetectable		 4ac9C-2isnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 7 ALA A 185
ARG A 235
THR A 207
GLU A 208
 None
 0.72A 5bs8A-2isnA:
undetectable
5bs8C-2isnA:
undetectable
5bs8D-2isnA:
undetectable		 5bs8A-2isnA:
21.97
5bs8C-2isnA:
21.97
5bs8D-2isnA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 7 ALA A 185
ARG A 235
THR A 207
GLU A 208
 None
 0.70A 5btdA-2isnA:
undetectable
5btdB-2isnA:
undetectable
5btdC-2isnA:
undetectable		 5btdA-2isnA:
21.97
5btdB-2isnA:
21.86
5btdC-2isnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 6 ALA A 185
ARG A 235
THR A 207
GLU A 208
 None
 0.73A 5btgA-2isnA:
undetectable
5btgB-2isnA:
undetectable
5btgC-2isnA:
undetectable		 5btgA-2isnA:
21.97
5btgB-2isnA:
21.86
5btgC-2isnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 7 ALA A 185
ARG A 235
THR A 207
GLU A 208
 None
 0.74A 5btgA-2isnA:
undetectable
5btgC-2isnA:
undetectable
5btgD-2isnA:
undetectable		 5btgA-2isnA:
21.97
5btgC-2isnA:
21.97
5btgD-2isnA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 6 CYH A  84
LEU A  69
CYH A  61
HIS A  64
 None
 1.13A 5hpuC-2isnA:
undetectable
5hpuD-2isnA:
undetectable		 5hpuC-2isnA:
6.54
5hpuD-2isnA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		5 / 12 LEU A 231
LEU A 233
GLY A 238
GLY A 102
GLY A  54
 None
 1.09A 6ce2B-2isnA:
undetectable		 6ce2B-2isnA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2isn NYSGXRC-8828Z,
PHOSPHATASE
(Toxoplasma
gondii) 		4 / 4 HIS A  52
VAL A 255
LEU A 231
ALA A 236
 None
 1.39A 6d8pB-2isnA:
undetectable		 6d8pB-2isnA:
19.77