SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ist'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 8 ILE A  86
LEU A  84
ILE A  96
VAL A 148
ILE A  94
 None
BCT  A 804 (-4.2A)
None
None
None
 1.47A 1linA-2istA:
undetectable		 1linA-2istA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 GLY A 133
VAL A 148
MET A 146
ILE A 126
 None
 0.77A 1pk7B-2istA:
undetectable		 1pk7B-2istA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 12 ALA A 241
ILE A 176
LEU A 279
PRO A 251
VAL A 252
 None
 0.91A 3em6B-2istA:
undetectable		 3em6B-2istA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 10 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 1.02A 3falC-2istA:
undetectable		 3falC-2istA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 11 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 1.02A 3fc6A-2istA:
undetectable		 3fc6A-2istA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 GLY A 133
VAL A 129
ILE A  93
VAL A 147
 None
 0.81A 3fi0I-2istA:
undetectable		 3fi0I-2istA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 9 GLN A  18
ASP A  21
ILE A  40
VAL A  45
VAL A  65
 None
 1.46A 3fi0R-2istA:
undetectable		 3fi0R-2istA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 4 ASN A  97
ALA A 299
GLY A 144
THR A 143
 None
 1.14A 4bboC-2istA:
undetectable		 4bboC-2istA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 6 GLU A  89
ILE A  93
HIS A 136
VAL A 104
 None
 1.10A 4ejwB-2istA:
undetectable		 4ejwB-2istA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 7 PRO A 302
VAL A 306
MET A 305
PHE A 274
 None
BCT  A 803 ( 4.1A)
None
None
 1.07A 4lb2A-2istA:
undetectable		 4lb2A-2istA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 TYR A 122
ILE A  86
ILE A  94
LYS A 150
 BCT  A 804 ( 4.3A)
None
None
None
 0.98A 4ou1A-2istA:
undetectable		 4ou1A-2istA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		3 / 3 THR A 197
MET A 199
HIS A 192
 None
 0.92A 5uunA-2istA:
undetectable		 5uunA-2istA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 7 GLY A 231
LEU A 228
LEU A 286
LEU A 138
ILE A  95
 None
None
None
CL  A 477 ( 4.5A)
None
 1.41A 5vkqA-2istA:
undetectable
5vkqB-2istA:
undetectable		 5vkqA-2istA:
11.52
5vkqB-2istA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		6 / 12 ASP A 250
LEU A 247
GLY A 249
PHE A 274
TYR A 253
THR A 222
 None
 1.48A 5x66F-2istA:
undetectable		 5x66F-2istA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 12 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 0.95A 6a5zL-2istA:
undetectable		 6a5zL-2istA:
12.83