SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2it1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 157
LEU A 164
LEU A 161
MET A 200
PHE A  31
 None
 1.33A 1d4fB-2it1A:
undetectable		 1d4fB-2it1A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 157
LEU A 164
LEU A 161
MET A 200
PHE A  31
 None
 1.24A 1d4fD-2it1A:
undetectable		 1d4fD-2it1A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 THR A 191
LEU A 157
LEU A  46
ILE A 212
LEU A 176
 None
 1.18A 1errB-2it1A:
undetectable		 1errB-2it1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 VAL A 206
LEU A 234
GLY A  36
PRO A  37
PHE A 229
 None
 1.40A 1fdsA-2it1A:
undetectable		 1fdsA-2it1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 137
LEU A 126
VAL A  92
LEU A  86
ALA A 143
 None
 1.08A 1gseB-2it1A:
undetectable		 1gseB-2it1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A 197
ASP A 193
VAL A 206
GLY A 235
ILE A 204
 None
 0.93A 1muiA-2it1A:
undetectable		 1muiA-2it1A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  24
LEU A  45
SER A  40
ALA A  33
ALA A 201
 None
 1.03A 2br4A-2it1A:
undetectable		 2br4A-2it1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  24
LEU A  45
SER A  40
ALA A  33
ALA A 201
 None
 1.00A 2br4D-2it1A:
undetectable		 2br4D-2it1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A  24
LEU A  45
SER A  40
ALA A  33
ALA A 201
 None
 1.05A 2br4F-2it1A:
undetectable		 2br4F-2it1A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 LEU A 348
ASN A 240
VAL A 242
GLY A 295
ILE A 279
 None
 0.82A 2f80A-2it1A:
undetectable		 2f80A-2it1A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 ARG A 173
GLU A 196
SER A 135
 None
 0.84A 2xctD-2it1A:
undetectable		 2xctD-2it1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A 172
LEU A 161
LEU A 164
ILE A 144
 None
 0.85A 3u5kA-2it1A:
undetectable		 3u5kA-2it1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A 172
LEU A 161
LEU A 164
ILE A 144
 None
 0.88A 3u5kC-2it1A:
undetectable		 3u5kC-2it1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A 172
LEU A 161
LEU A 164
ILE A 144
 None
 0.93A 3u5kD-2it1A:
undetectable		 3u5kD-2it1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A 207
ILE A 212
ALA A 205
LEU A  45
ILE A   4
 None
 1.13A 3uvvA-2it1A:
undetectable		 3uvvA-2it1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 VAL A 172
LEU A 161
LEU A 164
ILE A 144
 None
 0.86A 4a9jC-2it1A:
undetectable		 4a9jC-2it1A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 GLU A 299
GLY A 334
SER A 315
 None
 0.47A 4b53B-2it1A:
undetectable		 4b53B-2it1A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 9 ILE A 279
GLN A 264
LEU A 346
VAL A 341
LEU A 259
 None
 0.90A 4g1bC-2it1A:
undetectable		 4g1bC-2it1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 5 LEU A 259
PRO A 260
LEU A 251
ILE A 279
 None
 0.87A 4klrA-2it1A:
undetectable		 4klrA-2it1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 8 VAL A 172
LEU A 161
LEU A 164
ILE A 144
 None
 0.80A 4lzrA-2it1A:
undetectable		 4lzrA-2it1A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 PRO A  88
MET A  90
TYR A  87
 None
 0.95A 4qa2B-2it1A:
undetectable		 4qa2B-2it1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 TYR A  93
ILE A 123
VAL A 114
ALA A 118
 None
 0.90A 5cu6A-2it1A:
undetectable		 5cu6A-2it1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  49
PHE A  31
GLN A 180
ALA A  50
VAL A 154
 None
 1.29A 5n0xB-2it1A:
undetectable		 5n0xB-2it1A:
21.63