SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2it2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 9 ALA A 125
LEU A 121
ILE A 144
HIS A 109
LEU A 108
 None
 1.31A 1ereA-2it2A:
undetectable		 1ereA-2it2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 9 ALA A 125
LEU A 121
ILE A 144
HIS A 109
LEU A 108
 None
 1.31A 1ereB-2it2A:
undetectable		 1ereB-2it2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 9 ALA A 125
LEU A 121
ILE A 144
HIS A 109
LEU A 108
 None
 1.31A 1ereC-2it2A:
undetectable		 1ereC-2it2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 9 ALA A 125
LEU A 121
ILE A 144
HIS A 109
LEU A 108
 None
 1.31A 1ereD-2it2A:
undetectable		 1ereD-2it2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 10 ALA A 125
LEU A 121
ILE A 144
HIS A 109
LEU A 108
 None
 1.29A 1pcgA-2it2A:
undetectable		 1pcgA-2it2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		3 / 3 ASP A  34
LYS A 187
ARG A 190
 None
 1.15A 1ra8A-2it2A:
undetectable		 1ra8A-2it2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 12 ALA A  90
GLU A  89
LEU A  88
GLY A 161
LEU A  99
 None
 1.11A 2jfaB-2it2A:
undetectable		 2jfaB-2it2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		4 / 8 LEU A  38
ILE A 195
LEU A 191
LEU A 108
 None
 0.76A 2xfhA-2it2A:
undetectable		 2xfhA-2it2A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		4 / 7 GLY A 111
ALA A  18
ALA A  14
ILE A  42
 None
 0.76A 3a2qA-2it2A:
undetectable		 3a2qA-2it2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 6 MET A 153
VAL A 103
LEU A 108
ILE A 176
ILE A  58
 None
 1.34A 3gcsA-2it2A:
undetectable		 3gcsA-2it2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		4 / 5 ILE A 135
PHE A   7
ASP A 117
GLU A 116
 None
 1.09A 3kp6A-2it2A:
undetectable
3kp6B-2it2A:
undetectable		 3kp6A-2it2A:
22.94
3kp6B-2it2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		4 / 7 SER A  96
ALA A  72
GLU A  62
SER A  59
 None
 0.79A 4r1zB-2it2A:
undetectable		 4r1zB-2it2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		4 / 4 LEU A 156
MET A  63
ILE A 173
LEU A 102
 None
 0.96A 5nfpA-2it2A:
undetectable		 5nfpA-2it2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2it2 UPF0130 PROTEIN
PH1069
(Pyrococcus
horikoshii) 		5 / 10 ALA A 125
LEU A 121
ILE A 144
HIS A 109
LEU A 108
 None
 1.31A 6cbzB-2it2A:
undetectable		 6cbzB-2it2A:
18.09