SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2it4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 7 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.21A 1am6A-2it4A:
40.7		 1am6A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 8 PHE A  91
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
HIS A 200
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
PPF  A 500 (-3.9A)
None
 0.25A 1azmA-2it4A:
44.2		 1azmA-2it4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 8 PHE A  91
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
HIS A 200
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
PPF  A 500 (-3.9A)
None
 0.44A 1bzmA-2it4A:
44.3		 1bzmA-2it4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.50A 1cilA-2it4A:
40.8		 1cilA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.02A 1cilA-2it4A:
40.8		 1cilA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 11 HIS A  94
HIS A  96
HIS A 119
LEU A 141
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.45A 1dmyA-2it4A:
36.8		 1dmyA-2it4A:
44.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
VAL A 143
LEU A 141
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.31A 1dmyA-2it4A:
36.8		 1dmyA-2it4A:
44.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 1dmyB-2it4A:
36.9		 1dmyB-2it4A:
44.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_A_AZMA1400_1
(CARBONIC ANHYDRASE
XII)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.37A 1jd0A-2it4A:
35.6		 1jd0A-2it4A:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.43A 1jd0B-2it4A:
35.8		 1jd0B-2it4A:
36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.81A 1jd0B-2it4A:
35.8		 1jd0B-2it4A:
36.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 TYR A  20
ASN A  11
TRP A   5
TYR A   7
 None
 1.24A 1mxgA-2it4A:
undetectable		 1mxgA-2it4A:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.55A 1oq5A-2it4A:
41.0		 1oq5A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 GLN A  92
HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.24A 1oq5A-2it4A:
41.0		 1oq5A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.85A 1oq5A-2it4A:
41.0		 1oq5A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.56A 1rj6A-2it4A:
36.1		 1rj6A-2it4A:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 HIS A  94
HIS A  96
HIS A 119
LEU A 131
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.56A 1rj6A-2it4A:
36.1		 1rj6A-2it4A:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.56A 1rj6B-2it4A:
36.1		 1rj6B-2it4A:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 HIS A  94
HIS A  96
HIS A 119
LEU A 131
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.67A 1rj6B-2it4A:
36.1		 1rj6B-2it4A:
35.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 4 GLY A 196
SER A  29
ILE A 211
HIS A 107
 None
 1.24A 1yajJ-2it4A:
undetectable		 1yajJ-2it4A:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDA_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 10 GLN A  92
HIS A  94
HIS A 119
VAL A 143
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.6A)
None
 0.61A 1ydaA-2it4A:
40.4		 1ydaA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 11 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.6A)
None
 0.55A 1ydbA-2it4A:
40.7		 1ydbA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
THR A 199
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.6A)
 0.54A 1yddA-2it4A:
40.8		 1yddA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.65A 1z9yA-2it4A:
40.7		 1z9yA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  64
PHE A  91
LEU A 198
THR A 199
TRP A 209
 None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.77A 1z9yA-2it4A:
40.7		 1z9yA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
HIS A 107
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.88A 1z9yA-2it4A:
40.7		 1z9yA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 HIS A  64
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.53A 1zgfA-2it4A:
41.0		 1zgfA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.40A 1zsbA-2it4A:
41.1		 1zsbA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  96
GLU A 106
PHE A  91
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.92A 1zsbA-2it4A:
41.1		 1zsbA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  96
GLU A 106
VAL A 143
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.38A 1zsbA-2it4A:
41.1		 1zsbA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
LEU A 141
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.50A 2aw1A-2it4A:
40.6		 2aw1A-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		3 / 3 THR A 248
PRO A 250
PRO A  30
 None
 0.71A 2d55C-2it4A:
undetectable		 2d55C-2it4A:
8.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 6 TRP A   5
HIS A  64
GLN A  92
PRO A 202
 None
 0.70A 2ez7A-2it4A:
40.4		 2ez7A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 8 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.29A 2gehA-2it4A:
40.8		 2gehA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 8 HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.93A 2gehA-2it4A:
40.8		 2gehA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4N_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 9 GLN A  92
HIS A  96
HIS A 119
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
None
 0.42A 2h4nA-2it4A:
41.0		 2h4nA-2it4A:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.54A 2pouA-2it4A:
40.9		 2pouA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  64
PHE A  91
LEU A 198
THR A 199
TRP A 209
 None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.85A 2pouA-2it4A:
40.9		 2pouA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
HIS A 107
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.06A 2pouA-2it4A:
40.9		 2pouA-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 5 HIS A  64
HIS A 200
VAL A  62
HIS A  67
 None
PPF  A 500 (-3.9A)
None
None
 1.00A 2wkoF-2it4A:
undetectable		 2wkoF-2it4A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 HIS A  64
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.54A 3bl1A-2it4A:
40.7		 3bl1A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  64
HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.05A 3bl1A-2it4A:
40.7		 3bl1A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.26A 3cajA-2it4A:
40.6		 3cajA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  94
HIS A 119
THR A 199
PRO A 201
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
None
None
 1.27A 3cajA-2it4A:
40.6		 3cajA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.06A 3cajA-2it4A:
40.6		 3cajA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.90A 3cajA-2it4A:
40.6		 3cajA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.35A 3czvA-2it4A:
42.5
3czvB-2it4A:
42.3		 3czvA-2it4A:
60.55
3czvB-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  96
PHE A  91
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.99A 3czvA-2it4A:
42.5
3czvB-2it4A:
42.3		 3czvA-2it4A:
60.55
3czvB-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZV_B_AZMB263_1
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.39A 3czvB-2it4A:
42.3		 3czvB-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CZV_B_AZMB263_1
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  94
HIS A 119
VAL A 143
LEU A 198
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
None
 1.50A 3czvB-2it4A:
42.3		 3czvB-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 LEU A 118
LEU A 157
GLN A 158
VAL A 160
PHE A  66
 None
 1.17A 3datA-2it4A:
undetectable		 3datA-2it4A:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.50A 3dazA-2it4A:
41.0		 3dazA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.01A 3dazA-2it4A:
41.0		 3dazA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DAZ_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
VAL A 143
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.47A 3dazA-2it4A:
41.0		 3dazA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.44A 3dc3A-2it4A:
40.9		 3dc3A-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLU A 106
PHE A  91
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.91A 3dc3A-2it4A:
40.9		 3dc3A-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.81A 3dc3A-2it4A:
40.9		 3dc3A-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCS_A_MZMA263_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.40A 3dcsA-2it4A:
40.9		 3dcsA-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.33A 3dcwA-2it4A:
41.0		 3dcwA-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  94
HIS A 119
THR A 199
PRO A 201
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
None
None
 1.29A 3dcwA-2it4A:
41.0		 3dcwA-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.97A 3dcwA-2it4A:
41.0		 3dcwA-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.34A 3dd0A-2it4A:
41.0		 3dd0A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.95A 3dd0A-2it4A:
41.0		 3dd0A-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.86A 3eeyA-2it4A:
undetectable		 3eeyA-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.86A 3eeyB-2it4A:
undetectable		 3eeyB-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.85A 3eeyC-2it4A:
undetectable		 3eeyC-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.85A 3eeyD-2it4A:
undetectable		 3eeyD-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.86A 3eeyE-2it4A:
undetectable		 3eeyE-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.85A 3eeyH-2it4A:
undetectable		 3eeyH-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.84A 3eeyI-2it4A:
undetectable		 3eeyI-2it4A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLY A 196
ASN A  27
ILE A 211
GLY A 145
HIS A 119
 None
None
None
None
ZN  A 561 ( 3.1A)
 0.85A 3eeyJ-2it4A:
undetectable		 3eeyJ-2it4A:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F4X_A_KLTA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.57A 3f4xA-2it4A:
40.7		 3f4xA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.48A 3fw3A-2it4A:
31.3		 3fw3A-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 3fw3B-2it4A:
30.8		 3fw3B-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
None
 0.58A 3hkuA-2it4A:
40.7		 3hkuA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
PHE A  91
VAL A 143
LEU A 198
TRP A 209
 ZN  A 561 ( 3.2A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
None
 1.12A 3hkuA-2it4A:
40.7		 3hkuA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		3 / 3 GLU A 106
HIS A 119
THR A 199
 ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
 0.29A 3hkuA-2it4A:
40.7		 3hkuA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.50A 3hs4A-2it4A:
41.1		 3hs4A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 11 GLN A  92
HIS A  96
PHE A  91
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.27A 3hs4A-2it4A:
41.1		 3hs4A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 7 VAL A 109
TYR A 114
TRP A 192
LYS A 213
GLU A 214
 None
 0.55A 3hs4A-2it4A:
41.1		 3hs4A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 3iaiA-2it4A:
32.6		 3iaiA-2it4A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.89A 3iaiA-2it4A:
32.6		 3iaiA-2it4A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 3iaiB-2it4A:
33.0		 3iaiB-2it4A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.88A 3iaiB-2it4A:
33.0		 3iaiB-2it4A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 3iaiC-2it4A:
33.0		 3iaiC-2it4A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.87A 3iaiC-2it4A:
33.0		 3iaiC-2it4A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.59A 3iaiD-2it4A:
33.0		 3iaiD-2it4A:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.86A 3iaiD-2it4A:
33.0		 3iaiD-2it4A:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 LEU A 118
LEU A 157
LEU A 164
VAL A  68
THR A 183
 None
 1.14A 3ix9A-2it4A:
undetectable		 3ix9A-2it4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 LEU A 118
LEU A 157
GLN A 158
LEU A 164
VAL A  68
THR A 183
 None
 1.22A 3ix9B-2it4A:
undetectable		 3ix9B-2it4A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		3 / 3 ASN A  24
ASN A  26
GLU A 205
 None
 0.92A 3kpdC-2it4A:
undetectable		 3kpdC-2it4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		3 / 3 ASN A  24
ASN A  26
GLU A 205
 None
 0.85A 3kpdB-2it4A:
undetectable		 3kpdB-2it4A:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.60A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  94
HIS A 119
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 1.40A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.05A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A 119
VAL A 143
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.34A 3kwaA-2it4A:
40.6		 3kwaA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		10 / 12 HIS A  64
SER A  65
PHE A  91
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.30A 3lxeA-2it4A:
46.2		 3lxeA-2it4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		10 / 12 HIS A  64
SER A  65
PHE A  91
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.28A 3lxeB-2it4A:
46.3		 3lxeB-2it4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 HIS A  94
HIS A  96
GLU A 106
HIS A 119
ALA A 135
LEU A 198
THR A 199
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.58A 3mdzA-2it4A:
40.1		 3mdzA-2it4A:
51.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.88A 3mdzA-2it4A:
40.1		 3mdzA-2it4A:
51.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.54A 3ml5A-2it4A:
40.5		 3ml5A-2it4A:
51.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  96
PHE A  91
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.08A 3ml5A-2it4A:
40.5		 3ml5A-2it4A:
51.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 5 TRP A  97
HIS A  64
VAL A  62
HIS A  67
 None
 1.19A 3nneB-2it4A:
0.0		 3nneB-2it4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 ARG A 254
VAL A 109
GLY A 145
VAL A  31
ILE A  33
 None
 1.04A 3oxvD-2it4A:
undetectable		 3oxvD-2it4A:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.52A 3v2jA-2it4A:
41.0		 3v2jA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.00A 3v2jA-2it4A:
41.0		 3v2jA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.53A 3v2mA-2it4A:
41.2		 3v2mA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V2M_A_AZMA303_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 10 GLN A  92
HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.29A 3v2mA-2it4A:
41.2		 3v2mA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 8 GLN A  92
HIS A  94
HIS A  96
HIS A  64
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
None
 0.95A 3w6hA-2it4A:
45.0		 3w6hA-2it4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 8 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
HIS A 200
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
PPF  A 500 (-3.9A)
None
 0.33A 3w6hA-2it4A:
45.0		 3w6hA-2it4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W6H_B_AZMB303_1
(CARBONIC ANHYDRASE 1)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 9 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
HIS A 200
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
PPF  A 500 (-3.9A)
None
 0.35A 3w6hB-2it4A:
45.1		 3w6hB-2it4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.45A 3zncA-2it4A:
30.5		 3zncA-2it4A:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 LEU A 198
GLU A 117
HIS A 119
HIS A  94
 PPF  A 500 (-3.9A)
None
ZN  A 561 ( 3.1A)
ZN  A 561 ( 3.2A)
 1.22A 4aq7A-2it4A:
undetectable		 4aq7A-2it4A:
13.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_A_SANA300_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 4coqA-2it4A:
30.4		 4coqA-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.41A 4coqB-2it4A:
30.3		 4coqB-2it4A:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 ARG A 254
VAL A 109
GLY A 145
VAL A  31
ILE A  33
 None
 1.06A 4dqcA-2it4A:
undetectable		 4dqcA-2it4A:
15.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 GLN A  92
LEU A 141
VAL A 143
LEU A 198
THR A 199
VAL A 207
TRP A 209
 None
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.58A 4e3hA-2it4A:
40.7		 4e3hA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 10 PHE A  91
LEU A 141
LEU A 198
THR A 199
VAL A 207
TRP A 209
 None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 1.07A 4e3hA-2it4A:
40.7		 4e3hA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 VAL A 143
PHE A  91
LEU A 141
LEU A 198
THR A 199
 PPF  A 500 (-4.9A)
None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.02A 4e3hA-2it4A:
40.7		 4e3hA-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 PHE A  93
ASN A  69
PHE A 176
LEU A  90
 None
 0.96A 4ejgA-2it4A:
undetectable		 4ejgA-2it4A:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.51A 4g0cA-2it4A:
40.9		 4g0cA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 GLU A 106
PHE A  91
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.92A 4g0cA-2it4A:
40.9		 4g0cA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 GLU A 106
VAL A 143
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.30A 4g0cA-2it4A:
40.9		 4g0cA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.83A 4g0cA-2it4A:
40.9		 4g0cA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_A_AZMA302_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.56A 4g7aA-2it4A:
28.6		 4g7aA-2it4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.56A 4g7aB-2it4A:
28.4		 4g7aB-2it4A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.09A 4g7aB-2it4A:
28.4		 4g7aB-2it4A:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 9 PHE A  93
PHE A 226
ILE A 216
MET A 148
 None
 1.16A 4jvlA-2it4A:
undetectable		 4jvlA-2it4A:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 131
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 4k0sA-2it4A:
40.7		 4k0sA-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		10 / 12 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 131
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.53A 4k0zA-2it4A:
40.1		 4k0zA-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.96A 4k0zA-2it4A:
40.1		 4k0zA-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		10 / 12 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 131
LEU A 141
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
None
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.51A 4k13A-2it4A:
40.9		 4k13A-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A 119
HIS A 107
VAL A 143
LEU A 141
LEU A 198
THR A 199
 ZN  A 561 ( 3.1A)
None
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.49A 4k13A-2it4A:
40.9		 4k13A-2it4A:
60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.57A 4lu3A-2it4A:
35.7		 4lu3A-2it4A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 131
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.68A 4lu3A-2it4A:
35.7		 4lu3A-2it4A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.77A 4lu3A-2it4A:
35.7		 4lu3A-2it4A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.55A 4m2rA-2it4A:
41.1		 4m2rA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.90A 4m2rA-2it4A:
41.1		 4m2rA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2U_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 TRP A   5
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.51A 4m2uA-2it4A:
41.0		 4m2uA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2U_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 TRP A  16
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.35A 4m2uA-2it4A:
41.0		 4m2uA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.53A 4m2vA-2it4A:
40.8		 4m2vA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 141
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.51A 4m2wA-2it4A:
40.8		 4m2wA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 8 GLN A  92
HIS A  94
HIS A  96
HIS A 119
THR A 199
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
 0.57A 4n16A-2it4A:
41.0		 4n16A-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PXX_A_CHDA302_0
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
THR A 199
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
 0.60A 4pxxA-2it4A:
40.8		 4pxxA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_A_AZMA299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 4uovA-2it4A:
30.2		 4uovA-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_A_AZMA299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.99A 4uovA-2it4A:
30.2		 4uovA-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_B_AZMB299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 4uovB-2it4A:
30.2		 4uovB-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_B_AZMB299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.93A 4uovB-2it4A:
30.2		 4uovB-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_C_AZMC299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 4uovC-2it4A:
30.0		 4uovC-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_C_AZMC299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.99A 4uovC-2it4A:
30.0		 4uovC-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_D_AZMD299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.59A 4uovD-2it4A:
30.1		 4uovD-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_D_AZMD299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.97A 4uovD-2it4A:
30.1		 4uovD-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_E_AZME299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 4uovE-2it4A:
30.2		 4uovE-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_E_AZME299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.97A 4uovE-2it4A:
30.2		 4uovE-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_F_AZMF299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.59A 4uovF-2it4A:
30.2		 4uovF-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_F_AZMF299_1
(CARBONATE
DEHYDRATASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.96A 4uovF-2it4A:
30.2		 4uovF-2it4A:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_A_AZMA302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.57A 4x5sA-2it4A:
28.8		 4x5sA-2it4A:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_A_AZMA302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.88A 4x5sA-2it4A:
28.8		 4x5sA-2it4A:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_B_AZMB302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.57A 4x5sB-2it4A:
28.8		 4x5sB-2it4A:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_B_AZMB302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.89A 4x5sB-2it4A:
28.8		 4x5sB-2it4A:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_A_AZMA402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 4xiwA-2it4A:
26.1
4xiwH-2it4A:
26.0		 4xiwA-2it4A:
32.58
4xiwH-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_A_AZMA402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.99A 4xiwA-2it4A:
26.1
4xiwH-2it4A:
26.0		 4xiwA-2it4A:
32.58
4xiwH-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.61A 4xiwB-2it4A:
26.2
4xiwE-2it4A:
26.1		 4xiwB-2it4A:
32.58
4xiwE-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.86A 4xiwB-2it4A:
26.2
4xiwE-2it4A:
26.1		 4xiwB-2it4A:
32.58
4xiwE-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_C_AZMC402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.63A 4xiwC-2it4A:
25.9		 4xiwC-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_C_AZMC402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.95A 4xiwC-2it4A:
25.9		 4xiwC-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_D_AZMD402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 4xiwD-2it4A:
26.2		 4xiwD-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_D_AZMD402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.99A 4xiwD-2it4A:
26.2		 4xiwD-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.63A 4xiwE-2it4A:
26.1		 4xiwE-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.03A 4xiwE-2it4A:
26.1		 4xiwE-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.61A 4xiwF-2it4A:
25.9		 4xiwF-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.85A 4xiwF-2it4A:
25.9		 4xiwF-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		10 / 12 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 141
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.65A 4xiwG-2it4A:
26.0		 4xiwG-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 141
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.17A 4xiwG-2it4A:
26.0		 4xiwG-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.66A 4xiwH-2it4A:
26.0		 4xiwH-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.81A 4xiwH-2it4A:
26.0		 4xiwH-2it4A:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 VAL A 143
ILE A 144
LEU A 157
LEU A 184
 PPF  A 500 (-4.9A)
None
None
None
 0.83A 4xo7A-2it4A:
undetectable		 4xo7A-2it4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 11 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.38A 4ygfA-2it4A:
25.6		 4ygfA-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.44A 4ygfB-2it4A:
25.2		 4ygfB-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.45A 4ygfB-2it4A:
25.2		 4ygfB-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.05A 4ygfB-2it4A:
25.2		 4ygfB-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 11 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.31A 4ygfC-2it4A:
19.3		 4ygfC-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.30A 4ygfD-2it4A:
11.1		 4ygfD-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.82A 4ygfD-2it4A:
11.1		 4ygfD-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.30A 4ygfE-2it4A:
25.7		 4ygfE-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.46A 4ygfE-2it4A:
25.7		 4ygfE-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.02A 4ygfE-2it4A:
25.7		 4ygfE-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_F_AZMF303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.33A 4ygfF-2it4A:
25.6		 4ygfF-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.36A 4ygfG-2it4A:
6.0		 4ygfG-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_H_AZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.35A 4ygfH-2it4A:
25.6		 4ygfH-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.50A 4yhaA-2it4A:
25.4		 4yhaA-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.08A 4yhaA-2it4A:
25.4		 4yhaA-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 10 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.49A 4yhaB-2it4A:
24.7		 4yhaB-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 11 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.38A 4yhaC-2it4A:
25.7		 4yhaC-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.17A 4yhaC-2it4A:
25.7		 4yhaC-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 11 HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.44A 4yhaD-2it4A:
24.8		 4yhaD-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  94
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.49A 4yhaD-2it4A:
24.8		 4yhaD-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 11 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.13A 4yhaD-2it4A:
24.8		 4yhaD-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.45A 4yhaE-2it4A:
25.7		 4yhaE-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  94
HIS A 119
LEU A 198
THR A 199
PRO A 201
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 1.45A 4yhaE-2it4A:
25.7		 4yhaE-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.08A 4yhaE-2it4A:
25.7		 4yhaE-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 10 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.61A 4yhaF-2it4A:
23.4		 4yhaF-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.38A 4yhaG-2it4A:
25.1		 4yhaG-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.12A 4yhaG-2it4A:
25.1		 4yhaG-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 10 HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.36A 4yhaH-2it4A:
25.4		 4yhaH-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.06A 4yhaH-2it4A:
25.4		 4yhaH-2it4A:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 GLN A  92
HIS A  94
HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.52A 5c8iA-2it4A:
40.9		 5c8iA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  96
GLU A 106
PHE A  91
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.96A 5c8iA-2it4A:
40.9		 5c8iA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.87A 5c8iA-2it4A:
40.9		 5c8iA-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 LEU A 251
GLY A 196
SER A  17
ASN A  24
HIS A 107
 None
 1.36A 5d0yA-2it4A:
undetectable		 5d0yA-2it4A:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_A_AZMA701_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 5jn8A-2it4A:
30.9		 5jn8A-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.57A 5jn8B-2it4A:
31.1		 5jn8B-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.98A 5jn8B-2it4A:
31.1		 5jn8B-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_C_AZMC701_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.63A 5jn8C-2it4A:
30.7		 5jn8C-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_C_AZMC701_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 9 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.21A 5jn8C-2it4A:
30.7		 5jn8C-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.57A 5jn8D-2it4A:
30.8		 5jn8D-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.95A 5jn8D-2it4A:
30.8		 5jn8D-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_A_EZLA302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.61A 5jn9A-2it4A:
30.9		 5jn9A-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.55A 5jn9B-2it4A:
31.3		 5jn9B-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_C_EZLC302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 5jn9C-2it4A:
30.7		 5jn9C-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_C_EZLC302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 9 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.14A 5jn9C-2it4A:
30.7		 5jn9C-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.62A 5jn9D-2it4A:
30.8		 5jn9D-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.15A 5jn9D-2it4A:
30.8		 5jn9D-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.99A 5jnaA-2it4A:
30.9		 5jnaA-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 SER A  65
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.66A 5jnaA-2it4A:
30.9		 5jnaA-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.63A 5jnaB-2it4A:
31.1		 5jnaB-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 11 SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.67A 5jnaC-2it4A:
30.6		 5jnaC-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 12 SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 5jnaD-2it4A:
30.7		 5jnaD-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		9 / 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 5jncA-2it4A:
30.9		 5jncA-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 11 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.99A 5jncA-2it4A:
30.9		 5jncA-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 5jncB-2it4A:
31.2		 5jncB-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.16A 5jncB-2it4A:
31.2		 5jncB-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_C_6LHC302_0
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.58A 5jncC-2it4A:
30.6		 5jncC-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_D_6LHD302_0
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.61A 5jncD-2it4A:
30.8		 5jncD-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNC_D_6LHD302_0
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 9 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.18A 5jncD-2it4A:
30.8		 5jncD-2it4A:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 HIS A 122
HIS A 119
ILE A 144
TYR A  51
 None
ZN  A 561 ( 3.1A)
None
None
 1.20A 5kkzC-2it4A:
undetectable
5kkzE-2it4A:
undetectable		 5kkzC-2it4A:
20.08
5kkzE-2it4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 HIS A 119
ILE A 144
TYR A  51
HIS A 122
 ZN  A 561 ( 3.1A)
None
None
None
 1.22A 5kkzK-2it4A:
undetectable
5kkzQ-2it4A:
undetectable		 5kkzK-2it4A:
21.25
5kkzQ-2it4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 HIS A 122
HIS A 119
ILE A 144
TYR A  51
 None
ZN  A 561 ( 3.1A)
None
None
 1.22A 5kkzM-2it4A:
undetectable
5kkzO-2it4A:
undetectable		 5kkzM-2it4A:
20.08
5kkzO-2it4A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.62A 5ku6A-2it4A:
30.9		 5ku6A-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.60A 5ku6B-2it4A:
31.2		 5ku6B-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.17A 5ku6B-2it4A:
31.2		 5ku6B-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_C_MZMC301_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.61A 5ku6C-2it4A:
30.7		 5ku6C-2it4A:
31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KU6_D_MZMD301_1
(CARBONIC ANHYDRASE 4)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.61A 5ku6D-2it4A:
30.8		 5ku6D-2it4A:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 7 GLN A  92
HIS A  94
LEU A 198
THR A 199
 None
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.64A 5m78A-2it4A:
41.0		 5m78A-2it4A:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 6 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.17A 5ogjA-2it4A:
41.9		 5ogjA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 6 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.16A 5ogjB-2it4A:
42.2		 5ogjB-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 5 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 0.16A 5ohhA-2it4A:
42.5		 5ohhA-2it4A:
60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 6 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.17A 5ohhB-2it4A:
41.9		 5ohhB-2it4A:
60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.43A 5tt3A-2it4A:
25.5		 5tt3A-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 10 HIS A  94
HIS A 119
VAL A 143
LEU A 198
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
None
None
 1.46A 5tt3A-2it4A:
25.5		 5tt3A-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.04A 5tt3A-2it4A:
25.5		 5tt3A-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.36A 5tt3B-2it4A:
23.8		 5tt3B-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 10 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.41A 5tt3C-2it4A:
25.6		 5tt3C-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 10 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.05A 5tt3C-2it4A:
25.6		 5tt3C-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.36A 5tt3E-2it4A:
25.6		 5tt3E-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 9 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.04A 5tt3E-2it4A:
25.6		 5tt3E-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 8 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.50A 5tt3F-2it4A:
25.0		 5tt3F-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 8 HIS A  94
HIS A 119
VAL A 143
LEU A 198
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
None
 1.43A 5tt3F-2it4A:
25.0		 5tt3F-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 9 HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.38A 5tt3G-2it4A:
24.8		 5tt3G-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 9 HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
 1.04A 5tt3G-2it4A:
24.8		 5tt3G-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 8 HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.43A 5tt3H-2it4A:
25.0		 5tt3H-2it4A:
29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 GLU A 106
ASN A 244
LYS A   5
VAL A 218
LEU A 157
 ZN  A 561 ( 4.9A)
None
None
None
None
 1.13A 5vooB-2it4A:
undetectable		 5vooB-2it4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		3 / 3 GLU A 106
TRP A 209
HIS A  94
 ZN  A 561 ( 4.9A)
None
ZN  A 561 ( 3.2A)
 1.07A 5xipA-2it4A:
undetectable		 5xipA-2it4A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		7 / 12 TRP A   5
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.72A 6bbsA-2it4A:
32.6		 6bbsA-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 TRP A   5
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.49A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 None
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.16A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		4 / 5 GLU A 106
HIS A 119
LEU A 141
VAL A 143
 ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-4.9A)
 0.27A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		8 / 12 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.54A 6bccA-2it4A:
41.1		 6bccA-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		6 / 12 GLN A  92
HIS A  96
PHE A  91
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.25A 6bccA-2it4A:
41.1		 6bccA-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		5 / 12 HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.94A 6bccA-2it4A:
41.1		 6bccA-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens) 		3 / 3 VAL A 146
GLU A 117
ILE A 216
 None
 0.47A 6f7lB-2it4A:
undetectable		 6f7lB-2it4A:
20.51