SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2iu1 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5
(Homo
sapiens) 		4 / 6 LEU A 243
VAL A 247
LYS A 248
ILE A 263
 None
 0.76A 2piwA-2iu1A:
undetectable		 2piwA-2iu1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2iu1 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5
(Homo
sapiens) 		4 / 7 TYR A 313
TYR A 362
ARG A 312
HIS A 316
 None
 1.13A 2qmqA-2iu1A:
0.0		 2qmqA-2iu1A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2iu1 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5
(Homo
sapiens) 		4 / 5 ILE A 256
PHE A 300
VAL A 363
PHE A 244
 None
 1.27A 2ygnA-2iu1A:
undetectable		 2ygnA-2iu1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iu1 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5
(Homo
sapiens) 		4 / 5 ILE A 351
LEU A 382
ASP A 342
GLU A 347
 None
 0.93A 4nkxB-2iu1A:
undetectable		 4nkxB-2iu1A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2iu1 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5
(Homo
sapiens) 		5 / 9 LEU A 314
ILE A 293
ILE A 351
GLU A 349
GLU A 319
 None
 1.20A 5igzA-2iu1A:
undetectable		 5igzA-2iu1A:
20.66