SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 12 ALA A 264
ALA A 263
LEU A 322
LEU A 250
ALA A 247
 None
 0.97A 1fm9A-2iu3A:
undetectable		 1fm9A-2iu3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 ALA A 303
SER A 423
TRP A 248
LEU A 300
 None
 1.19A 1gahA-2iu3A:
undetectable		 1gahA-2iu3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 12 ALA A 264
ALA A 263
LEU A 322
LEU A 250
ALA A 247
 None
 0.97A 1k74A-2iu3A:
undetectable		 1k74A-2iu3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 12 LEU A  69
GLY A 128
GLY A 129
LEU A 104
LEU A 133
 None
 0.92A 1mx1D-2iu3A:
undetectable		 1mx1D-2iu3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 4 LYS A 332
LEU A 293
LEU A 297
SER A 302
 None
 1.38A 1tt6A-2iu3A:
undetectable		 1tt6A-2iu3A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 12 ALA A 263
ALA A 264
ASN A 246
LEU A 250
ALA A 262
 None
 0.92A 2aclA-2iu3A:
undetectable
2aclE-2iu3A:
undetectable		 2aclA-2iu3A:
18.62
2aclE-2iu3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 11 ALA A 263
ALA A 264
ASN A 246
LEU A 250
ALA A 262
 None
 0.98A 2aclE-2iu3A:
undetectable		 2aclE-2iu3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 4 LEU A 300
ILE A 334
ILE A 320
ALA A 321
 None
 0.88A 2i30A-2iu3A:
undetectable		 2i30A-2iu3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 MET A 289
SER A 489
ARG A 469
GLY A 309
 None
 1.40A 2y7pA-2iu3A:
undetectable		 2y7pA-2iu3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 8 GLY A 277
ILE A 320
SER A 302
THR A 330
 None
 0.88A 2yoeB-2iu3A:
2.2
2yoeC-2iu3A:
undetectable		 2yoeB-2iu3A:
20.48
2yoeC-2iu3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		3 / 3 PRO A 228
LEU A 227
ARG A 195
 None
 0.81A 3aqiA-2iu3A:
undetectable		 3aqiA-2iu3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 7 VAL A 561
SER A 423
THR A 586
LEU A 588
 None
 1.22A 3arrA-2iu3A:
undetectable		 3arrA-2iu3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 ASP A  51
LEU A  55
LEU A 132
HIS A  74
 None
 1.18A 3bj8C-2iu3A:
undetectable
3bj8D-2iu3A:
undetectable		 3bj8C-2iu3A:
14.09
3bj8D-2iu3A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 8 HIS A 585
ASP A 569
PHE A 543
GLY A 565
 None
 0.83A 3c0zB-2iu3A:
2.3		 3c0zB-2iu3A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 LEU A 254
SER A 323
LEU A 322
LEU A 250
 None
 1.03A 3f33A-2iu3A:
undetectable		 3f33A-2iu3A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 GLY A 128
GLY A 129
LEU A   9
HIS A  74
 None
 0.75A 3o9mB-2iu3A:
undetectable		 3o9mB-2iu3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 12 GLY A 277
LEU A 258
GLY A 259
ALA A 305
LEU A 280
 None
 1.06A 3vywC-2iu3A:
undetectable		 3vywC-2iu3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 LYS A 332
LEU A 293
LEU A 297
SER A 302
 None
 1.23A 4d7bB-2iu3A:
undetectable		 4d7bB-2iu3A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 9 VAL A 100
VAL A  99
VAL A  73
ILE A  77
ALA A 137
 None
 1.22A 4fwdA-2iu3A:
undetectable		 4fwdA-2iu3A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 12 ALA A 264
ALA A 263
LEU A 322
LEU A 250
ALA A 247
 None
 1.09A 4k6iA-2iu3A:
undetectable		 4k6iA-2iu3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 8 ARG A  23
ALA A  22
GLY A  17
LEU A  18
LEU A  10
 None
 1.25A 4po0A-2iu3A:
undetectable		 4po0A-2iu3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		5 / 8 ARG A  23
ALA A  22
GLY A  17
LEU A  18
LEU A  42
 None
 1.21A 4po0A-2iu3A:
undetectable		 4po0A-2iu3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 8 ALA A 275
ILE A 424
ALA A 425
LEU A 250
 None
 0.61A 5te8B-2iu3A:
undetectable		 5te8B-2iu3A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 ARG A 589
PHE A 543
ILE A 453
THR A 456
 None
 1.08A 5vceA-2iu3A:
undetectable		 5vceA-2iu3A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 6 MET A 368
ASN A 233
VAL A 231
LEU A 229
 None
 1.27A 5xdhA-2iu3A:
undetectable
5xdhC-2iu3A:
undetectable		 5xdhA-2iu3A:
10.08
5xdhC-2iu3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 5 MET A 368
ASN A 233
VAL A 231
LEU A 229
 None
 1.34A 5xdhB-2iu3A:
undetectable		 5xdhB-2iu3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 5 MET A 368
ASN A 233
VAL A 231
LEU A 229
 None
 1.13A 5xdhD-2iu3A:
undetectable		 5xdhD-2iu3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		3 / 3 TYR A 152
LEU A  25
ASP A 166
 None
 0.83A 5zv2B-2iu3A:
undetectable		 5zv2B-2iu3A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Gallus
gallus) 		4 / 4 HIS A  74
VAL A 100
LEU A 132
ALA A 135
 None
 1.44A 6d8pB-2iu3A:
3.2		 6d8pB-2iu3A:
23.21