SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 7 TYR A  93
PHE A  97
PHE A 103
PHE A  62
 None
 1.13A 1e71M-2iu5A:
undetectable		 1e71M-2iu5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 7 TYR A  93
PHE A  97
PHE A 103
PHE A  62
 None
 1.12A 1e72M-2iu5A:
undetectable		 1e72M-2iu5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 7 ILE A 154
LEU A 108
PHE A 107
PHE A  62
 None
 1.00A 2vctD-2iu5A:
undetectable		 2vctD-2iu5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 7 ASP A  71
SER A  70
GLU A  64
ASP A  61
 None
 1.26A 3bc9A-2iu5A:
undetectable		 3bc9A-2iu5A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 6 TRP A  56
PHE A  47
PHE A  43
PHE A  15
 None
 1.40A 4awuA-2iu5A:
undetectable		 4awuA-2iu5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 8 ASN A  67
GLN A 110
PHE A 106
ILE A 109
 None
 0.86A 4fglD-2iu5A:
undetectable		 4fglD-2iu5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 7 ASN A  67
GLN A 110
PHE A 106
ILE A 109
 None
 0.89A 4fglC-2iu5A:
undetectable		 4fglC-2iu5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 8 ILE A 119
LEU A  82
VAL A 168
LEU A 171
 None
 0.77A 4r38B-2iu5A:
undetectable		 4r38B-2iu5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		4 / 8 ILE A 119
LEU A  82
VAL A 168
LEU A 171
 None
 0.77A 4r38D-2iu5A:
undetectable		 4r38D-2iu5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		5 / 11 LEU A  53
PHE A  15
ASP A  17
ALA A  12
ILE A  91
 None
 1.39A 4uuuA-2iu5A:
undetectable
4uuuB-2iu5A:
undetectable		 4uuuA-2iu5A:
20.87
4uuuB-2iu5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS
(Lactococcus
lactis) 		3 / 3 LYS A  13
LEU A  54
ILE A  27
 None
 0.70A 5kc0A-2iu5A:
2.9		 5kc0A-2iu5A:
19.92