SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 9 ALA A 279
ILE A 257
VAL A 243
ILE A 287
ILE A 275
 None
 0.95A 1hshB-2iu8A:
undetectable		 1hshB-2iu8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 12 GLY A 262
GLY A 280
ALA A 264
ASP A 224
GLN A 278
 PLM  A1349 ( 4.2A)
PLM  A1349 (-3.7A)
PLM  A1349 (-3.2A)
None
None
 1.14A 1ri4A-2iu8A:
undetectable		 1ri4A-2iu8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 12 GLY A 310
ILE A 281
ILE A 287
ILE A 292
ALA A 261
 None
 0.92A 1sguB-2iu8A:
undetectable		 1sguB-2iu8A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 12 ILE A 185
VAL A 171
VAL A 233
GLU A 250
ILE A 263
 None
 1.07A 2vn0A-2iu8A:
undetectable		 2vn0A-2iu8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 11 ALA A 135
VAL A 131
ILE A 119
GLY A 138
ILE A 149
 None
 1.06A 3oxvD-2iu8A:
undetectable		 3oxvD-2iu8A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 10 ILE A 281
ALA A 261
SER A 255
SER A 237
ILE A 269
 None
 1.23A 3qgtB-2iu8A:
undetectable		 3qgtB-2iu8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		4 / 8 ALA A  12
GLY A  23
LEU A   8
LEU A  79
 None
 0.84A 4po0A-2iu8A:
undetectable		 4po0A-2iu8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		4 / 8 ILE A 285
GLY A 280
MET A 293
ILE A 263
 None
PLM  A1349 (-3.7A)
None
None
 0.83A 4qogA-2iu8A:
undetectable
4qogB-2iu8A:
undetectable		 4qogA-2iu8A:
19.54
4qogB-2iu8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2iu8 UDP-3-O-[3-HYDROXYMY
RISTOYL] GLUCOSAMINE
N-ACYLTRANSFERASE
(Chlamydia
trachomatis) 		5 / 10 ALA A 288
VAL A 291
ILE A 275
ILE A 263
VAL A 251
 None
 1.21A 5nukA-2iu8A:
undetectable		 5nukA-2iu8A:
11.98