SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iuc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		4 / 5 ASP B 259
HIS B 263
HIS B 302
HIS B 337
 ZN  B1006 (-2.1A)
ZN  B1006 (-3.2A)
ZN  B1007 (-3.1A)
ZN  B1006 ( 3.3A)
 0.38A 1ei6A-2iucB:
17.3		 1ei6A-2iucB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 8 ASP B  43
ASP B 259
HIS B 263
HIS B 302
HIS B 337
 ZN  B1007 ( 2.1A)
ZN  B1006 (-2.1A)
ZN  B1006 (-3.2A)
ZN  B1007 (-3.1A)
ZN  B1006 ( 3.3A)
 0.45A 1ei6C-2iucB:
17.2		 1ei6C-2iucB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		4 / 6 SER B 272
PHE B 332
GLU B 273
GLY B 261
 None
 0.97A 1kqbA-2iucB:
undetectable
1kqbB-2iucB:
undetectable		 1kqbA-2iucB:
21.75
1kqbB-2iucB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		4 / 5 TYR B 142
MET B 158
THR B 159
LEU B 187
 None
 1.23A 2eimW-2iucB:
undetectable		 2eimW-2iucB:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		4 / 8 TYR B  55
SER B  52
THR B  53
PRO B  61
 None
 1.14A 2v0zO-2iucB:
undetectable		 2v0zO-2iucB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		4 / 8 PHE B 307
GLY B 306
PHE B 332
ILE B 328
 None
 0.98A 3ko0O-2iucB:
undetectable
3ko0Q-2iucB:
undetectable		 3ko0O-2iucB:
13.71
3ko0Q-2iucB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 12 ALA B 167
GLY B 169
SER B 131
LEU B 215
ALA B 238
 None
 1.27A 3ou6C-2iucB:
undetectable		 3ou6C-2iucB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 12 ALA B 167
GLY B 169
SER B 132
LEU B 215
ALA B 238
 None
 1.24A 3ou6C-2iucB:
undetectable		 3ou6C-2iucB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 12 ALA B 167
GLY B 169
SER B 131
LEU B 215
ALA B 238
 None
 1.28A 3ou7C-2iucB:
undetectable		 3ou7C-2iucB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 12 ALA B 167
GLY B 169
SER B 132
LEU B 215
ALA B 238
 None
 1.23A 3ou7C-2iucB:
undetectable		 3ou7C-2iucB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		4 / 5 LEU B 231
ALA B 234
MET B 220
THR B 130
 None
 1.37A 3vasB-2iucB:
undetectable		 3vasB-2iucB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 12 ILE B 102
ALA B 100
ASP B  83
ILE B  95
ASN B 361
 None
 1.36A 4gh8B-2iucB:
2.5		 4gh8B-2iucB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		3 / 3 ASP B 164
ASN B 190
PHE B 141
 None
 0.84A 5jglB-2iucB:
undetectable		 5jglB-2iucB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 12 GLY B 261
PHE B 307
ILE B 342
GLY B 306
GLY B 305
 None
 0.93A 5koxA-2iucB:
undetectable		 5koxA-2iucB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		3 / 3 GLY B 198
THR B 200
ASN B 195
 None
 0.71A 5odiG-2iucB:
undetectable		 5odiG-2iucB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		4 / 4 GLY B 350
LEU B  31
VAL B 370
GLU B 353
 None
 1.13A 5yw0A-2iucB:
undetectable		 5yw0A-2iucB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		5 / 9 GLY B 350
VAL B 370
GLU B 353
GLY B 348
PRO B  34
 None
 1.41A 5zniA-2iucB:
undetectable		 5zniA-2iucB:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2iuc ALKALINE PHOSPHATASE
(Antarctic
bacterium
TAB5) 		3 / 3 LEU B 163
GLY B 212
PHE B 230
 None
 0.62A 6exiC-2iucB:
undetectable		 6exiC-2iucB:
14.19