SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iue'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 9 PHE A 116
TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.43A 1dz8A-2iueA:
undetectable		 1dz8A-2iueA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 10 PHE A 116
TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.45A 1o76A-2iueA:
undetectable		 1o76A-2iueA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 8 LEU A  26
ALA A 202
ILE A 205
GLY A 192
 None
 0.80A 1sv9A-2iueA:
undetectable		 1sv9A-2iueA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 12 LEU A 108
LEU A 110
LEU A 160
ALA A  93
ILE A  94
 None
 1.02A 1tw4A-2iueA:
undetectable		 1tw4A-2iueA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 12 LEU A 108
LEU A 110
LEU A 160
ILE A  94
ILE A  48
 None
 1.02A 1tw4A-2iueA:
undetectable		 1tw4A-2iueA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 8 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.10A 1uyuA-2iueA:
undetectable		 1uyuA-2iueA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 8 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.06A 1uyuB-2iueA:
undetectable		 1uyuB-2iueA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 11 TYR A 179
PHE A 116
VAL A 153
ILE A 186
LEU A 108
 None
 1.21A 1yatA-2iueA:
undetectable		 1yatA-2iueA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 6 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.02A 2feuA-2iueA:
undetectable		 2feuA-2iueA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 7 PHE A 116
TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.43A 2feuB-2iueA:
undetectable		 2feuB-2iueA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 12 LEU A 194
ILE A  48
GLY A  11
ASP A 113
GLY A  84
 None
 0.97A 3bwcB-2iueA:
undetectable		 3bwcB-2iueA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 7 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.02A 3fwfA-2iueA:
undetectable		 3fwfA-2iueA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 7 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.02A 3fwfB-2iueA:
undetectable		 3fwfB-2iueA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 7 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 0.97A 3l63A-2iueA:
undetectable		 3l63A-2iueA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 7 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.04A 3wrlA-2iueA:
undetectable		 3wrlA-2iueA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 7 PHE A 116
TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.41A 3wrlE-2iueA:
undetectable		 3wrlE-2iueA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 7 PHE A 116
TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.42A 3wrmF-2iueA:
undetectable		 3wrmF-2iueA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 8 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.06A 4l4fA-2iueA:
undetectable		 4l4fA-2iueA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 12 GLY A 192
ILE A 168
LEU A 194
VAL A 201
ILE A 205
 None
 1.01A 4uw0A-2iueA:
undetectable		 4uw0A-2iueA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 12 TYR A 179
PHE A 116
VAL A 153
ILE A 186
LEU A 108
 None
 1.15A 5b8iC-2iueA:
undetectable		 5b8iC-2iueA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 11 TYR A 179
PHE A 116
VAL A 153
ILE A 186
LEU A 108
 None
 1.17A 5huaA-2iueA:
undetectable		 5huaA-2iueA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 11 TYR A 179
PHE A 116
VAL A 153
ILE A 186
ILE A  48
 None
 1.10A 5hw8A-2iueA:
undetectable
5hw8D-2iueA:
undetectable		 5hw8A-2iueA:
21.60
5hw8D-2iueA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 8 VAL A 109
ILE A 205
ALA A 202
PHE A 169
VAL A 170
 None
 1.18A 5l94A-2iueA:
undetectable		 5l94A-2iueA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 8 HIS A  55
GLN A  85
GLY A  11
LEU A  12
 None
 0.79A 5w3jB-2iueA:
undetectable		 5w3jB-2iueA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		4 / 7 TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.01A 5wk9A-2iueA:
undetectable		 5wk9A-2iueA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		3 / 3 GLY A 100
ASP A   5
ILE A  43
 None
 0.53A 6dgxB-2iueA:
undetectable		 6dgxB-2iueA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2iue INTEGRIN BETA-2-LIKE
PROTEIN
(Mus
musculus) 		5 / 10 LEU A  26
ASP A  29
ILE A  43
PHE A  66
ILE A 205
 None
 1.13A 6ebpD-2iueA:
undetectable		 6ebpD-2iueA:
17.91