SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 11 ILE A 772
GLY A 577
GLU A 580
LEU A 736
GLY A 586
None
1.24A 1i7qA-2iukA:
undetectable
1i7qA-2iukA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 11 GLY A 852
GLU A 851
ASP A 786
LEU A 272
ILE A  28
None
1.24A 1jzsA-2iukA:
undetectable
1jzsA-2iukA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ILE A  11
TRP A 113
PHE A 117
GLU A 112
None
1.38A 1nsiA-2iukA:
undetectable
1nsiB-2iukA:
undetectable
1nsiA-2iukA:
19.30
1nsiB-2iukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 TRP A 113
PHE A 117
GLU A 112
ILE A  11
None
1.38A 1nsiA-2iukA:
undetectable
1nsiB-2iukA:
undetectable
1nsiA-2iukA:
19.30
1nsiB-2iukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ILE A  11
TRP A 113
PHE A 117
GLU A 112
None
1.35A 1nsiC-2iukA:
undetectable
1nsiD-2iukA:
undetectable
1nsiC-2iukA:
19.30
1nsiD-2iukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 TRP A 113
PHE A 117
GLU A 112
ILE A  11
None
1.40A 1nsiC-2iukA:
undetectable
1nsiD-2iukA:
undetectable
1nsiC-2iukA:
19.30
1nsiD-2iukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 ARG A 372
GLY A 722
VAL A 378
GLU A 369
None
0.88A 1pk7B-2iukA:
undetectable
1pk7B-2iukA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 HIS A 530
HIS A 525
HIS A 716
FE  A 901 (-3.5A)
FE  A 901 (-3.3A)
FE  A 901 (-3.5A)
0.69A 1rkyA-2iukA:
2.3
1rkyA-2iukA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 LYS A 767
ILE A 764
THR A 451
None
0.80A 1rx3A-2iukA:
undetectable
1rx3A-2iukA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ARG A 847
ILE A 643
GLY A 640
ALA A 637
None
0.87A 1wmqA-2iukA:
undetectable
1wmqA-2iukA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ARG A 847
ILE A 643
GLY A 640
ALA A 637
None
0.87A 1wmqB-2iukA:
undetectable
1wmqB-2iukA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 ASP A 276
GLU A 794
ARG A 265
None
0.76A 1wopA-2iukA:
1.6
1wopA-2iukA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ARG A 847
ILE A 643
GLY A 640
ALA A 637
None
0.84A 1wpuA-2iukA:
undetectable
1wpuA-2iukA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ARG A 847
ILE A 643
GLY A 640
ALA A 637
None
0.84A 1wpuB-2iukA:
1.4
1wpuB-2iukA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ARG A 847
ILE A 643
GLY A 640
ALA A 637
None
0.83A 1wrqA-2iukA:
undetectable
1wrqA-2iukA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ARG A 847
ILE A 643
GLY A 640
ALA A 637
None
0.87A 1wrqB-2iukA:
undetectable
1wrqB-2iukA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 ARG A 782
GLU A 787
PRO A 859
ALA A 717
None
1.46A 2ejfB-2iukA:
undetectable
2ejfB-2iukA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 ALA A 606
ASP A 610
GLY A 640
ILE A 643
None
0.74A 2fxdB-2iukA:
undetectable
2fxdB-2iukA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 VAL A 532
TRP A 710
TRP A 600
PHE A 602
None
1.28A 2g6hA-2iukA:
undetectable
2g6hB-2iukA:
undetectable
2g6hA-2iukA:
19.49
2g6hB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 SER A 477
SER A 490
VAL A 492
LEU A 386
None
1.06A 2hdnE-2iukA:
undetectable
2hdnF-2iukA:
undetectable
2hdnH-2iukA:
undetectable
2hdnE-2iukA:
3.64
2hdnF-2iukA:
16.88
2hdnH-2iukA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 SER A 490
VAL A 492
LEU A 386
SER A 477
None
1.00A 2hdnF-2iukA:
undetectable
2hdnG-2iukA:
undetectable
2hdnH-2iukA:
undetectable
2hdnF-2iukA:
16.88
2hdnG-2iukA:
3.64
2hdnH-2iukA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 GLY A 223
PRO A 258
LYS A 257
THR A 249
None
1.37A 2m2oB-2iukA:
undetectable
2m2oB-2iukA:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 ILE A 730
ILE A 579
ASN A 379
VAL A 378
None
0.54A 2nniA-2iukA:
undetectable
2nniA-2iukA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 TRP A 113
PHE A 117
GLU A 112
ILE A  11
None
1.38A 2nsiA-2iukA:
undetectable
2nsiB-2iukA:
undetectable
2nsiA-2iukA:
19.30
2nsiB-2iukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 ILE A  11
TRP A 113
PHE A 117
GLU A 112
None
1.36A 2nsiC-2iukA:
undetectable
2nsiD-2iukA:
undetectable
2nsiC-2iukA:
19.30
2nsiD-2iukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 TRP A 113
PHE A 117
GLU A 112
ILE A  11
None
1.37A 2nsiC-2iukA:
undetectable
2nsiD-2iukA:
undetectable
2nsiC-2iukA:
19.30
2nsiD-2iukA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 PRO A 841
ASN A 826
ARG A 834
None
0.73A 2qeuB-2iukA:
undetectable
2qeuB-2iukA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 12 ILE A 573
ILE A 777
LEU A 780
VAL A 378
LEU A 522
None
0.95A 2qo5A-2iukA:
undetectable
2qo5A-2iukA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 12 PHE A 768
SER A 775
LEU A 316
ILE A 730
LEU A 285
None
1.30A 2xkwA-2iukA:
0.0
2xkwA-2iukA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 SER A 704
CYH A 705
GLN A 672
ILE A 550
None
1.19A 2xz5A-2iukA:
undetectable
2xz5B-2iukA:
undetectable
2xz5A-2iukA:
13.92
2xz5B-2iukA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 12 THR A  74
ILE A 119
GLY A 118
PHE A 117
LEU A 184
None
1.11A 2y7kD-2iukA:
undetectable
2y7kD-2iukA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 HIS A 716
HIS A 530
HIS A 525
FE  A 901 (-3.5A)
FE  A 901 (-3.5A)
FE  A 901 (-3.3A)
0.73A 3ag4A-2iukA:
undetectable
3ag4A-2iukA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 TRP A 710
TRP A 600
PHE A 602
VAL A 532
None
1.15A 3b3pA-2iukA:
undetectable
3b3pB-2iukA:
2.6
3b3pA-2iukA:
19.49
3b3pB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 GLY A  78
GLY A  82
GLY A  80
None
0.38A 3bogC-2iukA:
undetectable
3bogC-2iukA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 PHE A 439
ASP A 516
TYR A 435
PRO A 585
None
1.46A 3jqaA-2iukA:
undetectable
3jqaA-2iukA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 SER A 524
ASN A 379
GLN A 723
ASN A 528
None
1.19A 3n62A-2iukA:
undetectable
3n62A-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 SER A 524
ASN A 379
GLN A 723
ASN A 528
None
1.21A 3n66B-2iukA:
undetectable
3n66B-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 TYR A 210
TYR A 555
GLU A 191
None
0.83A 3pfgA-2iukA:
undetectable
3pfgA-2iukA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 THR A 394
ASP A 434
GLU A 475
None
0.67A 3qowA-2iukA:
undetectable
3qowA-2iukA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 ILE A 327
ILE A 331
VAL A 289
LEU A 292
None
0.66A 3r9vA-2iukA:
undetectable
3r9vB-2iukA:
2.6
3r9vA-2iukA:
16.59
3r9vB-2iukA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 ILE A 149
PHE A 117
LYS A  86
GLY A  85
None
1.22A 3sj0X-2iukA:
undetectable
3sj0X-2iukA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 ARG A 243
THR A 244
ASP A 213
GLU A 256
None
1.17A 3v5vC-2iukA:
0.0
3v5vD-2iukA:
0.0
3v5vC-2iukA:
20.44
3v5vD-2iukA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 12 LEU A  90
ILE A 125
SER A  67
CYH A 153
PHE A 133
None
1.25A 3vw1D-2iukA:
undetectable
3vw1D-2iukA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 GLN A 521
HIS A 525
HIS A 716
HIS A 530
None
FE  A 901 (-3.3A)
FE  A 901 (-3.5A)
FE  A 901 (-3.5A)
0.86A 3w6hA-2iukA:
undetectable
3w6hA-2iukA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 TRP A 600
TRP A 691
THR A 603
None
1.46A 4bboB-2iukA:
undetectable
4bboB-2iukA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 GLU A 256
ARG A 243
THR A 244
ASP A 213
None
1.20A 4e7cA-2iukA:
0.0
4e7cB-2iukA:
0.0
4e7cA-2iukA:
20.44
4e7cB-2iukA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 SER A 594
TYR A 236
VAL A 214
ASP A 685
None
1.26A 4eohB-2iukA:
undetectable
4eohB-2iukA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 ARG A 614
TYR A 636
TYR A 634
TRP A 710
None
1.28A 4f8yA-2iukA:
undetectable
4f8yB-2iukA:
undetectable
4f8yA-2iukA:
12.27
4f8yB-2iukA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 ARG A 614
TYR A 636
TYR A 634
TRP A 710
None
1.33A 4f8yC-2iukA:
undetectable
4f8yD-2iukA:
undetectable
4f8yC-2iukA:
12.27
4f8yD-2iukA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 9 GLY A 682
PRO A 239
TYR A 597
GLY A 231
TYR A 215
None
1.34A 4fimA-2iukA:
undetectable
4fimA-2iukA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 LYS A 767
ILE A 764
THR A 451
None
0.86A 4gh8A-2iukA:
undetectable
4gh8A-2iukA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 SER A 524
ASN A 379
GLN A 723
ASN A 528
None
1.20A 4kcnB-2iukA:
undetectable
4kcnB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 11 HIS A 783
PRO A 859
HIS A 520
PHE A 721
HIS A 525
None
None
None
None
FE  A 901 (-3.3A)
1.28A 4lxzB-2iukA:
undetectable
4lxzB-2iukA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 GLN A 521
HIS A 525
HIS A 716
HIS A 530
None
FE  A 901 (-3.3A)
FE  A 901 (-3.5A)
FE  A 901 (-3.5A)
0.87A 4n16A-2iukA:
undetectable
4n16A-2iukA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 ILE A 579
GLN A 521
HIS A 525
HIS A 716
None
None
FE  A 901 (-3.3A)
FE  A 901 (-3.5A)
0.89A 4n16A-2iukA:
undetectable
4n16A-2iukA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 PRO A 333
LEU A 334
HIS A 287
None
0.61A 4pevA-2iukA:
undetectable
4pevA-2iukA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 PHE A 307
TYR A 760
GLY A 728
ILE A 777
None
0.95A 4qoiA-2iukA:
undetectable
4qoiB-2iukA:
undetectable
4qoiA-2iukA:
16.39
4qoiB-2iukA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 GLU A 267
TYR A 551
LEU A 544
TYR A 210
None
1.08A 4twdF-2iukA:
2.3
4twdJ-2iukA:
undetectable
4twdF-2iukA:
16.78
4twdJ-2iukA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 ASN A  21
PHE A 133
TYR A 158
None
0.83A 4u15A-2iukA:
undetectable
4u15A-2iukA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 TYR A 317
PRO A 352
LEU A 774
TYR A 724
None
1.36A 4w5qA-2iukA:
1.2
4w5qA-2iukA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 12 GLN A 521
HIS A 525
HIS A 716
HIS A 530
VAL A 776
None
FE  A 901 (-3.3A)
FE  A 901 (-3.5A)
FE  A 901 (-3.5A)
None
0.99A 4xiwB-2iukA:
undetectable
4xiwE-2iukA:
undetectable
4xiwB-2iukA:
13.83
4xiwE-2iukA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 TYR A 317
PRO A 352
LEU A 774
TYR A 724
None
1.40A 4z4cA-2iukA:
undetectable
4z4cA-2iukA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 LEU A  70
GLN A  69
PHE A 111
LEU A 140
None
0.99A 5b3sC-2iukA:
2.7
5b3sJ-2iukA:
undetectable
5b3sC-2iukA:
13.51
5b3sJ-2iukA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 LEU A  70
GLN A  69
PHE A 111
LEU A 140
None
1.00A 5b3sP-2iukA:
2.7
5b3sP-2iukA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 ARG A 372
LEU A 840
ASN A 732
VAL A 356
None
1.44A 5cshB-2iukA:
undetectable
5cshB-2iukA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 ASN A 172
LEU A 184
PHE A 169
None
0.74A 5dsgA-2iukA:
undetectable
5dsgA-2iukA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 ASP A 211
ASN A 541
PHE A 536
None
0.69A 5dsgB-2iukA:
undetectable
5dsgB-2iukA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 4 LEU A 844
ARG A 847
ILE A 858
ILE A 643
None
1.04A 5dzk2-2iukA:
undetectable
5dzkM-2iukA:
undetectable
5dzkN-2iukA:
undetectable
5dzk2-2iukA:
1.08
5dzkM-2iukA:
12.33
5dzkN-2iukA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 4 ILE A 858
ILE A 643
ARG A 847
LEU A 844
None
1.22A 5dzkh-2iukA:
undetectable
5dzkn-2iukA:
undetectable
5dzkv-2iukA:
undetectable
5dzkh-2iukA:
12.33
5dzkn-2iukA:
12.33
5dzkv-2iukA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 THR A 394
ASP A 434
GLU A 475
None
0.77A 5fa8A-2iukA:
undetectable
5fa8A-2iukA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 LEU A 349
LEU A 774
PHE A 341
LEU A 285
None
0.97A 5gs4A-2iukA:
undetectable
5gs4A-2iukA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 ILE A 864
MET A 533
ASP A 560
None
0.80A 5h2uA-2iukA:
undetectable
5h2uA-2iukA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 LYS A 648
TRP A 650
SER A 706
None
1.32A 5nwwA-2iukA:
undetectable
5nwwA-2iukA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 ARG A 372
LEU A 840
ASN A 732
VAL A 356
None
1.43A 5os7B-2iukA:
0.0
5os7B-2iukA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 ARG A 314
LEU A 729
THR A 770
LEU A 774
None
0.92A 5te8C-2iukA:
undetectable
5te8C-2iukA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 4 SER A 362
THR A 468
ASP A 465
ASP A 367
None
1.24A 5vimA-2iukA:
undetectable
5vimA-2iukA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 4 SER A 362
THR A 468
ASP A 465
ASP A 367
None
1.23A 5vimB-2iukA:
undetectable
5vimB-2iukA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 SER A 524
ASN A 379
GLN A 723
ASN A 528
None
1.22A 5vunB-2iukA:
undetectable
5vunB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 SER A 524
ASN A 379
GLN A 723
ASN A 528
None
1.20A 5vuoB-2iukA:
undetectable
5vuoB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 7 HIS A 625
ASP A 633
TYR A 634
LEU A 463
None
1.21A 5x1fA-2iukA:
1.5
5x1fC-2iukA:
2.8
5x1fP-2iukA:
undetectable
5x1fA-2iukA:
20.50
5x1fC-2iukA:
13.51
5x1fP-2iukA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 ASN A 515
PRO A 766
THR A 765
PRO A 734
None
1.17A 5x23A-2iukA:
undetectable
5x23A-2iukA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2iuk SEED LIPOXYGENASE
(Glycine
max)
5 / 12 PHE A 768
SER A 775
LEU A 316
ILE A 730
LEU A 285
None
1.14A 5ycpA-2iukA:
undetectable
5ycpA-2iukA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 VAL A  88
TYR A  89
GLU A 112
None
0.84A 5zmqD-2iukA:
undetectable
5zmqE-2iukA:
undetectable
5zmqD-2iukA:
11.88
5zmqE-2iukA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 SER A 524
ASN A 379
GLN A 723
ASN A 528
None
1.23A 6auuB-2iukA:
undetectable
6auuB-2iukA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)
2iuk SEED LIPOXYGENASE
(Glycine
max)
3 / 3 ARG A 739
LYS A 478
ARG A 762
None
1.47A 6az3C-2iukA:
undetectable
6az3L-2iukA:
undetectable
6az3M-2iukA:
0.0
6az3C-2iukA:
6.57
6az3L-2iukA:
8.05
6az3M-2iukA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 5 ARG A 372
LEU A 840
ASN A 732
VAL A 356
None
1.43A 6gmdA-2iukA:
0.0
6gmdA-2iukA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 6 TYR A 215
ILE A 590
ALA A 568
ARG A 569
None
1.15A 6hu9m-2iukA:
undetectable
6hu9q-2iukA:
0.0
6hu9m-2iukA:
21.31
6hu9q-2iukA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2iuk SEED LIPOXYGENASE
(Glycine
max)
4 / 8 TRP A 675
ASP A 685
TRP A 674
HIS A 543
None
1.03A 6nknC-2iukA:
2.7
6nknN-2iukA:
undetectable
6nknP-2iukA:
2.8
6nknC-2iukA:
13.51
6nknN-2iukA:
20.50
6nknP-2iukA:
13.51