SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ius'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		4 / 8 LEU A 872
PRO A 932
VAL A 934
GLY A 935
 None
 1.03A 1hrkB-2iusA:
undetectable		 1hrkB-2iusA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		5 / 12 LEU A1119
ALA A 997
ALA A1155
VAL A1117
TYR A1032
 None
 1.30A 1kt4A-2iusA:
undetectable		 1kt4A-2iusA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		5 / 9 TYR A1010
LEU A 846
ILE A1005
TYR A1032
ILE A1035
 None
 1.19A 1q6iA-2iusA:
undetectable		 1q6iA-2iusA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		5 / 10 THR A1044
VAL A1043
THR A1040
GLU A1041
THR A1247
 None
 1.25A 1r55A-2iusA:
undetectable		 1r55A-2iusA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		4 / 6 ILE A1172
MET A 984
PRO A 985
VAL A1227
 None
 1.05A 2ygoA-2iusA:
undetectable		 2ygoA-2iusA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		3 / 3 PRO A1024
THR A1044
LEU A1027
 None
 0.74A 3ttrA-2iusA:
undetectable		 3ttrA-2iusA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		5 / 12 VAL A1043
ILE A1172
ILE A1138
VAL A1134
LEU A1053
 None
 1.07A 3w67B-2iusA:
undetectable		 3w67B-2iusA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		5 / 11 ILE A 906
ALA A 873
LEU A 872
VAL A 868
LEU A 895
 None
 1.03A 4g1bB-2iusA:
undetectable		 4g1bB-2iusA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		5 / 12 VAL A1215
LEU A 987
THR A1174
GLY A1208
GLY A 969
 None
 1.25A 5tuiB-2iusA:
undetectable		 5tuiB-2iusA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2ius DNA TRANSLOCASE FTSK
(Escherichia
coli) 		5 / 10 LEU A 968
GLY A1219
GLY A1202
SER A1207
HIS A1218
 None
 1.11A 5twjB-2iusA:
undetectable		 5twjB-2iusA:
16.57