SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 652
MET A 678
THR A 648
LEU A 462
 None
 1.27A 1ea1A-2iutA:
undetectable		 1ea1A-2iutA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 462
GLY A 676
GLY A 471
ILE A 650
TYR A 680
 None
AGS  A1723 (-3.6A)
AGS  A1723 (-3.1A)
None
None
 1.04A 1p91B-2iutA:
2.5		 1p91B-2iutA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 608
VAL A 594
ALA A 524
LEU A 528
 None
 0.87A 1pthA-2iutA:
undetectable		 1pthA-2iutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 608
VAL A 594
ALA A 524
LEU A 528
 None
 0.88A 1pthB-2iutA:
undetectable		 1pthB-2iutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 8 ARG A 398
LEU A 672
ILE A 650
GLY A 444
LEU A 679
 None
 1.36A 2o4nB-2iutA:
undetectable		 2o4nB-2iutA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 484
LEU A 480
VAL A 701
ALA A 492
GLY A 509
 None
 1.29A 2vmyB-2iutA:
undetectable		 2vmyB-2iutA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 498
VAL A 476
ASN A 477
VAL A 701
ASP A 698
 None
 1.46A 2x0yA-2iutA:
undetectable		 2x0yA-2iutA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 646
MET A 459
PRO A 460
VAL A 701
 None
 1.19A 2ygoA-2iutA:
undetectable		 2ygoA-2iutA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 673
GLU A 412
ILE A 413
 None
 0.53A 3czhA-2iutA:
undetectable		 3czhA-2iutA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 350
VAL A 352
ILE A 411
VAL A 399
 None
 0.90A 3hjoB-2iutA:
undetectable		 3hjoB-2iutA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 701
SER A 697
VAL A 474
ALA A 478
LEU A 484
 None
None
AGS  A1723 (-3.5A)
None
None
 1.01A 3hs6A-2iutA:
undetectable		 3hs6A-2iutA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 9 PHE A 553
VAL A 547
VAL A 557
ASN A 549
GLY A 552
 None
 1.40A 3km6B-2iutA:
0.0		 3km6B-2iutA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 9 PHE A 553
VAL A 547
VAL A 557
ASN A 549
GLY A 552
 None
 1.43A 3kmoA-2iutA:
undetectable		 3kmoA-2iutA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 514
PRO A 516
ARG A 493
HIS A 512
 None
 1.05A 3ltwA-2iutA:
undetectable		 3ltwA-2iutA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 518
ILE A 646
ILE A 612
VAL A 608
LEU A 528
 None
 0.97A 3w67B-2iutA:
undetectable		 3w67B-2iutA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 652
HIS A 692
LEU A 673
LEU A 672
 None
 1.22A 5dzke-2iutA:
undetectable
5dzks-2iutA:
undetectable		 5dzke-2iutA:
17.47
5dzks-2iutA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 627
ILE A 495
MET A 479
 None
 0.67A 5i9yA-2iutA:
undetectable		 5i9yA-2iutA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 4 GLN A 671
VAL A 399
GLU A 401
ILE A 381
 None
 1.44A 5jncA-2iutA:
0.0		 5jncA-2iutA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 597
ASP A 599
LEU A 721
 None
 0.74A 5uhbC-2iutA:
2.2		 5uhbC-2iutA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2iut DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 693
GLY A 444
GLY A 449
ARG A 450
PRO A 430
 AGS  A1723 (-4.0A)
None
None
None
None
 1.09A 6ce2B-2iutA:
undetectable		 6ce2B-2iutA:
10.02