SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 572
ASP A 579
ASP A 578
PRO A 581
 None
 1.15A 1ilqA-2iuuA:
undetectable
1ilqC-2iuuA:
undetectable		 1ilqA-2iuuA:
10.32
1ilqC-2iuuA:
2.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 457
ILE A 615
THR A 648
PRO A 647
LEU A 550
 None
 1.19A 1rv7A-2iuuA:
undetectable
1rv7B-2iuuA:
undetectable		 1rv7A-2iuuA:
12.74
1rv7B-2iuuA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 645
ILE A 624
TYR A 539
LEU A 456
ALA A 621
 None
 1.43A 2iyfB-2iuuA:
undetectable		 2iyfB-2iuuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 8 ARG A 398
LEU A 672
ILE A 650
GLY A 444
LEU A 679
 None
 1.33A 2o4nB-2iuuA:
undetectable		 2o4nB-2iuuA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 484
LEU A 480
VAL A 701
ALA A 492
GLY A 509
 None
 1.29A 2vmyB-2iuuA:
2.0		 2vmyB-2iuuA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 646
MET A 459
PRO A 460
VAL A 701
 None
 1.14A 2ygoA-2iuuA:
undetectable		 2ygoA-2iuuA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 427
LEU A 318
SER A 319
VAL A 701
 None
 0.94A 3d2tA-2iuuA:
undetectable		 3d2tA-2iuuA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 701
SER A 697
VAL A 474
ALA A 478
LEU A 484
 None
None
ADP  A1723 (-3.7A)
None
None
 1.00A 3hs6A-2iuuA:
undetectable		 3hs6A-2iuuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 705
VAL A 701
SER A 697
VAL A 474
 None
None
None
ADP  A1723 (-3.7A)
 0.92A 3hs6B-2iuuA:
undetectable		 3hs6B-2iuuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 9 PHE A 553
VAL A 547
VAL A 557
ASN A 549
GLY A 552
 None
 1.47A 3km6B-2iuuA:
0.0		 3km6B-2iuuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 514
PRO A 516
ARG A 493
HIS A 512
 None
 1.08A 3ltwA-2iuuA:
undetectable		 3ltwA-2iuuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 518
ILE A 646
ILE A 612
VAL A 608
LEU A 528
 None
 0.96A 3w67B-2iuuA:
undetectable		 3w67B-2iuuA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 645
ILE A 624
TYR A 539
LEU A 456
ALA A 621
 None
 1.46A 4m83A-2iuuA:
undetectable		 4m83A-2iuuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 534
ILE A 717
LEU A 456
GLY A 623
ILE A 624
 None
 1.07A 4o1eA-2iuuA:
undetectable		 4o1eA-2iuuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 534
ILE A 717
LEU A 456
GLY A 623
ILE A 624
 None
 1.03A 4o1eB-2iuuA:
undetectable		 4o1eB-2iuuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 549
ALA A 551
ARG A 555
 None
 0.56A 5cvtB-2iuuA:
undetectable		 5cvtB-2iuuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 646
ILE A 663
ILE A 650
LEU A 664
 None
 0.83A 5fukA-2iuuA:
undetectable
5fukB-2iuuA:
undetectable		 5fukA-2iuuA:
20.00
5fukB-2iuuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 599
ALA A 598
ASP A 659
GLN A 653
GLY A 466
 None
 1.23A 5hfjF-2iuuA:
undetectable		 5hfjF-2iuuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 591
ILE A 510
LEU A 480
LEU A 504
VAL A 593
 None
 1.27A 5im2A-2iuuA:
undetectable		 5im2A-2iuuA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 703
ALA A 707
PRO A 316
PHE A 485
 None
 1.17A 5odqA-2iuuA:
undetectable		 5odqA-2iuuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2iuu DNA TRANSLOCASE FTSK
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 384
LEU A 347
GLU A 401
VAL A 399
ILE A 411
 None
 1.05A 5v02B-2iuuA:
undetectable
5v02R-2iuuA:
undetectable		 5v02B-2iuuA:
11.79
5v02R-2iuuA:
14.40