SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iuw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		4 / 5 LEU A  92
VAL A  90
TYR A  78
ARG A  70
 None
 1.21A 1nw3A-2iuwA:
undetectable		 1nw3A-2iuwA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		3 / 3 LEU A  92
LEU A 245
SER A 206
 None
None
AKG  A 700 ( 4.1A)
 0.61A 1tlmA-2iuwA:
undetectable		 1tlmA-2iuwA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		6 / 11 HIS A 191
ASP A 193
HIS A 257
VAL A 259
ARG A 269
SER A 208
 FE  A 500 ( 3.3A)
FE  A 500 ( 2.6A)
FE  A 500 ( 3.3A)
None
AKG  A 700 (-2.9A)
AKG  A 700 ( 4.8A)
 1.30A 1uofA-2iuwA:
3.4		 1uofA-2iuwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		4 / 6 ALA A 102
ASP A 103
GLU A 101
ARG A 164
 None
 1.38A 2ouzA-2iuwA:
undetectable		 2ouzA-2iuwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		4 / 7 ASN A 271
ASP A 193
HIS A 191
HIS A 257
 AKG  A 700 (-3.4A)
FE  A 500 ( 2.6A)
FE  A 500 ( 3.3A)
FE  A 500 ( 3.3A)
 1.00A 3t01A-2iuwA:
undetectable		 3t01A-2iuwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		3 / 3 VAL A 270
GLN A 108
CYH A 110
 None
None
BME  A 802 (-1.9A)
 0.68A 5icxA-2iuwA:
undetectable
5icxE-2iuwA:
undetectable		 5icxA-2iuwA:
21.40
5icxE-2iuwA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		5 / 10 VAL A 188
ASP A 193
THR A 133
MET A 148
TYR A 181
 None
FE  A 500 ( 2.6A)
LED  A 177 ( 4.3A)
None
AKG  A 700 (-4.1A)
 1.35A 6aogA-2iuwA:
undetectable		 6aogA-2iuwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		5 / 10 VAL A 188
ASP A 193
THR A 133
MET A 148
TYR A 181
 None
FE  A 500 ( 2.6A)
LED  A 177 ( 4.3A)
None
AKG  A 700 (-4.1A)
 1.40A 6aogB-2iuwA:
undetectable		 6aogB-2iuwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		4 / 7 SER A 206
SER A 208
GLY A 242
ARG A 269
 AKG  A 700 ( 4.1A)
AKG  A 700 ( 4.8A)
None
AKG  A 700 (-2.9A)
 1.05A 6btxA-2iuwA:
undetectable		 6btxA-2iuwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		5 / 11 ILE A 237
PRO A  94
LEU A 239
SER A 206
LEU A 207
 None
None
None
AKG  A 700 ( 4.1A)
None
 1.42A 6dlzA-2iuwA:
undetectable
6dlzD-2iuwA:
undetectable		 6dlzA-2iuwA:
15.15
6dlzD-2iuwA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens) 		5 / 11 ILE A 237
PRO A  94
LEU A 239
SER A 206
LEU A 207
 None
None
None
AKG  A 700 ( 4.1A)
None
 1.42A 6dm1A-2iuwA:
undetectable
6dm1D-2iuwA:
undetectable		 6dm1A-2iuwA:
15.15
6dm1D-2iuwA:
15.15