SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 400
LYS A 395
VAL A 396
 None
 0.99A 1l2iA-2iv0A:
undetectable		 1l2iA-2iv0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 PRO A  98
GLY A 319
SER A 320
ALA A 349
ALA A 317
 None
 1.24A 1nw5A-2iv0A:
undetectable		 1nw5A-2iv0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 131
ILE A 311
THR A 348
 None
 0.74A 1rx3A-2iv0A:
undetectable		 1rx3A-2iv0A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 PHE A 401
ILE A 370
LYS A 371
THR A 348
 None
 0.95A 1sbrB-2iv0A:
undetectable		 1sbrB-2iv0A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 273
GLY A 238
ILE A 293
LEU A 295
ALA A 294
 None
 1.17A 1x7pA-2iv0A:
undetectable
1x7pB-2iv0A:
undetectable		 1x7pA-2iv0A:
23.37
1x7pB-2iv0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 MET A 205
TYR A 360
ALA A 122
ILE A 114
ILE A  88
 None
 1.06A 2bjfA-2iv0A:
undetectable		 2bjfA-2iv0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 9 LEU A 110
ILE A 114
PHE A  33
THR A  84
LEU A  99
 None
 1.12A 2m9qA-2iv0A:
undetectable		 2m9qA-2iv0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 311
ALA A 349
GLY A 315
GLY A 312
PRO A 331
 None
 1.11A 2okcA-2iv0A:
undetectable		 2okcA-2iv0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 311
ALA A 349
GLY A 315
GLY A 312
PRO A 331
 None
 1.14A 2okcB-2iv0A:
undetectable		 2okcB-2iv0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 305
VAL A 127
ARG A 125
ILE A 147
 ZN  A1415 (-2.5A)
None
None
None
 0.81A 2yfbA-2iv0A:
undetectable		 2yfbA-2iv0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 6 ASP A 305
VAL A 127
ARG A 125
ILE A 147
 ZN  A1415 (-2.5A)
None
None
None
 0.87A 2yfbB-2iv0A:
undetectable		 2yfbB-2iv0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A 333
GLY A  35
VAL A  42
LEU A  99
LEU A 110
 None
 1.11A 3cjtG-2iv0A:
2.5		 3cjtG-2iv0A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A 333
GLY A  35
VAL A  42
LEU A  99
LEU A 110
 None
 1.10A 3cjtK-2iv0A:
undetectable		 3cjtK-2iv0A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		6 / 12 HIS A 333
GLY A  35
GLY A  37
VAL A  42
LEU A  99
LEU A 110
 None
 1.25A 3cjtO-2iv0A:
undetectable		 3cjtO-2iv0A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 HIS A 333
GLY A  35
GLY A  39
LEU A  99
LEU A 110
 None
 0.94A 3cjtO-2iv0A:
undetectable		 3cjtO-2iv0A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 201
MET A 205
ARG A 204
 None
 1.43A 3uvvA-2iv0A:
undetectable		 3uvvA-2iv0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 120
TYR A 121
GLY A 325
GLY A  20
LEU A 118
 None
 1.16A 4blvA-2iv0A:
undetectable		 4blvA-2iv0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 131
ILE A 311
THR A 348
 None
 0.76A 4gh8A-2iv0A:
1.9		 4gh8A-2iv0A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 9 ALA A  68
ILE A 114
VAL A 328
ALA A  87
ILE A  88
 None
 1.10A 4lbgB-2iv0A:
2.4		 4lbgB-2iv0A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 349
PHE A 401
THR A 398
ASN A 408
THR A 377
 None
 1.45A 4z7fC-2iv0A:
undetectable		 4z7fC-2iv0A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 315
GLY A 313
GLY A 312
HIS A 333
ASP A 386
 None
 0.84A 5c0oF-2iv0A:
undetectable		 5c0oF-2iv0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 306
ALA A 308
VAL A 127
LEU A 284
VAL A 143
 None
 1.26A 5eb5A-2iv0A:
undetectable		 5eb5A-2iv0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 306
ALA A 308
VAL A 127
LEU A 284
VAL A 143
 None
 1.29A 5eb5B-2iv0A:
undetectable		 5eb5B-2iv0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 7 ILE A 159
GLY A 158
PHE A 197
ASP A 154
 None
 1.01A 5hieA-2iv0A:
undetectable		 5hieA-2iv0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 GLY A  39
ALA A 349
VAL A  42
ASP A  36
ILE A  38
 None
 1.17A 5i3cB-2iv0A:
undetectable		 5i3cB-2iv0A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 12 PRO A  98
GLY A 334
GLY A 327
LEU A 118
LEU A 120
 None
 1.11A 5wwsA-2iv0A:
undetectable		 5wwsA-2iv0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 303
ALA A 307
TYR A 290
GLU A 253
SER A 217
 None
 0.92A 6b89B-2iv0A:
0.8		 6b89B-2iv0A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		4 / 6 TYR A 290
VAL A 270
VAL A 218
THR A 219
 None
 1.39A 6f32B-2iv0A:
undetectable		 6f32B-2iv0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 11 ASP A 119
GLY A 300
SER A 304
ALA A 307
ASN A 321
 None
 1.12A 6hu9A-2iv0A:
undetectable
6hu9E-2iv0A:
undetectable
6hu9I-2iv0A:
undetectable		 6hu9A-2iv0A:
22.01
6hu9E-2iv0A:
18.58
6hu9I-2iv0A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2iv0 ISOCITRATE
DEHYDROGENASE
(Archaeoglobus
fulgidus) 		5 / 10 ASP A 119
GLY A 300
SER A 304
ALA A 307
ASN A 321
 None
 1.05A 6hu9L-2iv0A:
undetectable
6hu9P-2iv0A:
undetectable
6hu9T-2iv0A:
undetectable		 6hu9L-2iv0A:
22.01
6hu9P-2iv0A:
18.58
6hu9T-2iv0A:
9.50