SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 5 HIS X 149
SER X 311
LEU X 227
GLY X 305
 None
 1.00A 1a4lB-2iv2X:
undetectable		 1a4lB-2iv2X:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 GLY X 334
GLN X 335
GLN X 463
THR X  36
ILE X 161
 MGD  X 802 ( 3.3A)
2MD  X 801 (-3.2A)
None
None
None
 1.34A 1p93A-2iv2X:
undetectable		 1p93A-2iv2X:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 ALA X 398
ILE X 400
ALA X 436
LEU X  75
MET X  66
 None
 1.09A 1uduB-2iv2X:
undetectable		 1uduB-2iv2X:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 10 LEU X 318
LEU X 315
ILE X 234
ILE X 270
LEU X 227
 None
 1.17A 1wopA-2iv2X:
undetectable		 1wopA-2iv2X:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 HIS X 149
ASP X 349
LEU X 347
MET X 297
GLN X 339
 None
None
None
UNX  X 804 (-3.8A)
None
 1.34A 1xosA-2iv2X:
undetectable		 1xosA-2iv2X:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 GLY X 296
ASP X 202
VAL X 200
ILE X 206
VAL X 170
 MGD  X 802 (-3.1A)
MGD  X 802 (-2.7A)
None
MGD  X 802 (-4.1A)
None
 0.85A 2bpxB-2iv2X:
undetectable		 2bpxB-2iv2X:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 LYS X 545
ASP X 537
ASP X 535
 None
 1.12A 2br4A-2iv2X:
2.5		 2br4A-2iv2X:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 LYS X 547
ASP X 349
ASP X 549
 None
 0.94A 2br4D-2iv2X:
2.7		 2br4D-2iv2X:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 PRO X 331
VAL X 309
MET X 297
TRP X 295
 None
None
UNX  X 804 (-3.8A)
None
 1.06A 2hrcA-2iv2X:
undetectable		 2hrcA-2iv2X:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 ASN X 166
ASN X 330
LEU X 294
ALA X 288
ASP X 459
 None
 1.36A 2iyfB-2iv2X:
3.1		 2iyfB-2iv2X:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 GLY X 296
ASP X 202
VAL X 200
ILE X 206
VAL X 170
 MGD  X 802 (-3.1A)
MGD  X 802 (-2.7A)
None
MGD  X 802 (-4.1A)
None
 0.85A 2o4sA-2iv2X:
undetectable		 2o4sA-2iv2X:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 8 PRO X 331
VAL X 309
MET X 297
TRP X 295
 None
None
UNX  X 804 (-3.8A)
None
 1.02A 2qd3A-2iv2X:
undetectable		 2qd3A-2iv2X:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 GLY X 345
THR X 350
PHE X 512
PHE X 462
 None
 1.20A 2qx4A-2iv2X:
undetectable
2qx4B-2iv2X:
undetectable		 2qx4A-2iv2X:
15.97
2qx4B-2iv2X:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 LEU X 227
SER X 311
TYR X 255
THR X 559
 None
 1.17A 2uz2A-2iv2X:
undetectable		 2uz2A-2iv2X:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 VAL X 441
ILE X 485
PHE X 123
MET X 120
GLN X 428
 None
 1.21A 2weyA-2iv2X:
undetectable		 2weyA-2iv2X:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 GLY X 296
ASP X 202
VAL X 200
ILE X 206
VAL X 170
 MGD  X 802 (-3.1A)
MGD  X 802 (-2.7A)
None
MGD  X 802 (-4.1A)
None
 0.89A 3jvyB-2iv2X:
undetectable		 3jvyB-2iv2X:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 9 ARG X  90
ARG X 396
LEU X 424
GLU X 423
GLY X  99
 None
 1.47A 3nxuB-2iv2X:
undetectable		 3nxuB-2iv2X:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 11 VAL X 576
ALA X 649
GLY X 648
ALA X 217
ASN X 220
 None
None
None
None
MGD  X 802 ( 4.8A)
 1.49A 3qxyB-2iv2X:
undetectable
3qxyQ-2iv2X:
undetectable		 3qxyB-2iv2X:
20.87
3qxyQ-2iv2X:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 THR X 130
GLY X 380
ASN X 132
GLY X 345
 None
 0.78A 3tajA-2iv2X:
undetectable		 3tajA-2iv2X:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 5 HIS X 451
THR X   6
GLU X 450
ASP X  54
 2MD  X 801 (-4.7A)
None
None
None
 1.41A 3tm4A-2iv2X:
undetectable		 3tm4A-2iv2X:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 5 HIS X 451
THR X   6
GLU X 450
ASP X  54
 2MD  X 801 (-4.7A)
None
None
None
 1.38A 3tm4B-2iv2X:
undetectable		 3tm4B-2iv2X:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 TYR X 255
LEU X 227
ILE X 235
VAL X 259
ALA X 281
 None
 1.10A 4a6dA-2iv2X:
undetectable		 4a6dA-2iv2X:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 PHE X 462
PHE X 455
GLN X 335
ALA X 341
MET X 344
 None
None
2MD  X 801 (-3.2A)
None
None
 1.39A 4a83A-2iv2X:
undetectable		 4a83A-2iv2X:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 ARG X  68
ASP X 404
GLN X 407
 None
2MD  X 801 (-4.7A)
None
 0.87A 4azsA-2iv2X:
undetectable		 4azsA-2iv2X:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 6 HIS X 149
GLU X 385
ASP X 101
ASP X 349
 None
 1.32A 4blvA-2iv2X:
2.1		 4blvA-2iv2X:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 PHE X 525
ASN X 336
GLY X  14
THR X  36
 None
None
SF4  X 800 ( 4.5A)
None
 1.00A 4ejjB-2iv2X:
undetectable		 4ejjB-2iv2X:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 8 PRO X 331
VAL X 309
MET X 297
TRP X 295
 None
None
UNX  X 804 (-3.8A)
None
 1.05A 4f4dB-2iv2X:
undetectable		 4f4dB-2iv2X:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 VAL X 469
ARG X  28
THR X   6
GLU X  30
ALA X  29
 None
 1.29A 4fiaA-2iv2X:
undetectable		 4fiaA-2iv2X:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 VAL X 469
ARG X  28
THR X   6
GLU X  30
ALA X  29
 None
 1.29A 4fiaA-2iv2X:
undetectable		 4fiaA-2iv2X:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 6 THR X 130
GLY X 380
ASN X 132
GLY X 345
 None
 0.84A 4fjpA-2iv2X:
undetectable		 4fjpA-2iv2X:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 THR X 130
GLY X 380
ASN X 132
GLY X 345
 None
 0.74A 4forA-2iv2X:
undetectable		 4forA-2iv2X:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 ASP X 343
ARG X 138
THR X 456
 None
 0.86A 4i13A-2iv2X:
undetectable		 4i13A-2iv2X:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 9 TYR X  10
CYH X 588
HIS X 585
ILE X 430
 None
2MD  X 801 (-4.2A)
None
2MD  X 801 (-4.2A)
 1.24A 4jvlA-2iv2X:
undetectable		 4jvlA-2iv2X:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 GLY X 113
GLY X 111
THR X 116
ASN X 114
GLY X 107
 None
2MD  X 801 (-3.8A)
None
None
None
 1.15A 4n48A-2iv2X:
undetectable		 4n48A-2iv2X:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 GLY X 113
GLY X 111
THR X 116
ASN X 114
GLY X 107
 None
2MD  X 801 (-3.8A)
None
None
None
 1.12A 4n48B-2iv2X:
undetectable		 4n48B-2iv2X:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 ASN X 114
ASP X 343
ASP X 459
 None
 0.85A 4obwD-2iv2X:
2.5		 4obwD-2iv2X:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 ASP X 343
ARG X 138
THR X 456
 None
 0.84A 4p3rA-2iv2X:
undetectable		 4p3rA-2iv2X:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 ALA X 555
GLY X 320
ALA X 291
ALA X 316
TYR X 285
 None
 1.04A 4pclA-2iv2X:
2.4		 4pclA-2iv2X:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 LEU X 577
ILE X 610
ILE X 620
ILE X 636
ILE X 650
 None
 1.03A 4q1yB-2iv2X:
undetectable		 4q1yB-2iv2X:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 ALA X 346
GLY X 340
GLN X 339
GLY X 353
TYR X 356
 None
 1.26A 4r29A-2iv2X:
undetectable		 4r29A-2iv2X:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 PRO X 529
SER X 541
ASP X 165
THR X 167
 None
 1.23A 4uacA-2iv2X:
undetectable		 4uacA-2iv2X:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 7 ALA X  88
SER X  92
ILE X 103
LEU X 424
 None
 0.82A 4uymA-2iv2X:
undetectable		 4uymA-2iv2X:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 6 PRO X 348
ILE X 383
VAL X 395
THR X 130
 None
 1.19A 4xe5A-2iv2X:
4.7		 4xe5A-2iv2X:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 VAL X 273
LEU X 218
ILE X 216
VAL X 299
LEU X 312
 None
 1.04A 4y8wA-2iv2X:
undetectable		 4y8wA-2iv2X:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 VAL X 273
LEU X 218
ILE X 216
VAL X 299
LEU X 312
 None
 1.10A 4y8wB-2iv2X:
undetectable		 4y8wB-2iv2X:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 6 ILE X 430
PHE X 431
ARG X  61
ILE X  52
 2MD  X 801 (-4.2A)
None
None
None
 1.00A 4zzcA-2iv2X:
undetectable
4zzcB-2iv2X:
undetectable		 4zzcA-2iv2X:
17.87
4zzcB-2iv2X:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 6 ILE X 430
PHE X 431
ARG X  61
ILE X  52
 2MD  X 801 (-4.2A)
None
None
None
 1.08A 4zzcB-2iv2X:
undetectable
4zzcC-2iv2X:
undetectable		 4zzcB-2iv2X:
17.87
4zzcC-2iv2X:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 ASP X 101
GLU X 385
SER X 374
 None
 0.82A 5bw4B-2iv2X:
1.5		 5bw4B-2iv2X:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EDL_A_VIBA201_1
(PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 TYR X  10
TRP X 448
ILE X 430
SER X 590
ARG X 110
 None
None
2MD  X 801 (-4.2A)
2MD  X 801 (-3.2A)
2MD  X 801 (-4.4A)
 1.47A 5edlA-2iv2X:
0.6		 5edlA-2iv2X:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 GLN X  38
ILE X 183
VAL X 184
GLY X  14
SER X  13
 None
SF4  X 800 (-3.8A)
None
SF4  X 800 ( 4.5A)
SF4  X 800 (-3.6A)
 1.11A 5ergB-2iv2X:
undetectable		 5ergB-2iv2X:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 ILE X 224
GLU X 307
GLY X 305
CYH X 201
LEU X 312
 None
 1.31A 5fhzD-2iv2X:
undetectable		 5fhzD-2iv2X:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 6 GLU X 253
PHE X 252
GLU X 260
VAL X 259
 None
 1.36A 5h4dA-2iv2X:
5.4		 5h4dA-2iv2X:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 5 GLY X 345
PRO X 510
GLN X 355
THR X 350
 None
 1.30A 5h5fA-2iv2X:
undetectable		 5h5fA-2iv2X:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 SER X 445
LEU X  75
MET X  66
 2MD  X 801 (-2.9A)
None
None
 0.70A 5ikrB-2iv2X:
undetectable		 5ikrB-2iv2X:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 THR X 130
THR X 105
THR X 106
ALA X 398
GLY X 380
 None
 1.11A 5lf7V-2iv2X:
undetectable
5lf7b-2iv2X:
undetectable		 5lf7V-2iv2X:
16.42
5lf7b-2iv2X:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 THR X 130
THR X 105
THR X 106
ALA X 398
GLY X 380
 None
 1.11A 5lf7H-2iv2X:
undetectable
5lf7N-2iv2X:
undetectable		 5lf7H-2iv2X:
16.42
5lf7N-2iv2X:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		3 / 3 THR X  36
HIS X 187
ASN X 186
 None
 0.89A 5n4tA-2iv2X:
undetectable		 5n4tA-2iv2X:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 10 PRO X 510
ALA X 515
GLY X 539
THR X 540
ILE X 526
 None
 1.06A 5vyhA-2iv2X:
undetectable		 5vyhA-2iv2X:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 5 GLY X 340
ASP X 343
ARG X 460
GLN X 463
 None
 1.35A 5zrfB-2iv2X:
undetectable		 5zrfB-2iv2X:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 6 PHE X 512
GLY X 353
GLN X 339
TYR X 354
 None
 1.27A 6ag0A-2iv2X:
undetectable		 6ag0A-2iv2X:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 TYR X 285
PHE X 244
ALA X 229
THR X 308
LEU X 312
 None
 1.25A 6aybA-2iv2X:
undetectable		 6aybA-2iv2X:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 5 GLN X 121
VAL X 119
PRO X 352
THR X 498
 None
 1.12A 6cduA-2iv2X:
undetectable
6cduB-2iv2X:
undetectable		 6cduA-2iv2X:
17.97
6cduB-2iv2X:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 5 GLN X 121
VAL X 119
PRO X 352
THR X 498
 None
 1.21A 6cduI-2iv2X:
undetectable
6cduJ-2iv2X:
undetectable		 6cduI-2iv2X:
17.97
6cduJ-2iv2X:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		5 / 12 CYH X 140
ARG X 382
VAL X 306
GLY X 147
SER X 384
 None
 1.47A 6ci6A-2iv2X:
0.0		 6ci6A-2iv2X:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 4 ILE X 161
LEU X 294
HIS X 326
ALA X 292
 None
 0.96A 6ck2C-2iv2X:
undetectable
6ck2D-2iv2X:
undetectable		 6ck2C-2iv2X:
2.90
6ck2D-2iv2X:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2iv2 FORMATE
DEHYDROGENASE H
(Escherichia
coli) 		4 / 8 VAL X 332
TYR X 175
HIS X 187
GLU X 163
 None
MGD  X 802 (-4.9A)
None
None
 1.32A 6gneB-2iv2X:
2.2		 6gneB-2iv2X:
21.23