SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 0.97A 1c9hA-2iv8A:
undetectable		 1c9hA-2iv8A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 1.00A 1fkbA-2iv8A:
undetectable		 1fkbA-2iv8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 11 PHE A 762
VAL A 923
ILE A 927
ILE A 934
PHE A 826
 None
 1.25A 1fkjA-2iv8A:
undetectable		 1fkjA-2iv8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 11 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 1.03A 2dg3A-2iv8A:
undetectable		 2dg3A-2iv8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 11 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 1.02A 2dg4A-2iv8A:
undetectable		 2dg4A-2iv8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 8 THR A 913
GLN A 906
SER A 915
TYR A 888
 None
 1.12A 2xz5C-2iv8A:
undetectable
2xz5D-2iv8A:
undetectable		 2xz5C-2iv8A:
22.85
2xz5D-2iv8A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 11 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 0.91A 4drjA-2iv8A:
undetectable		 4drjA-2iv8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 10 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 0.95A 4qt2A-2iv8A:
undetectable		 4qt2A-2iv8A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 10 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 0.95A 4qt3A-2iv8A:
undetectable		 4qt3A-2iv8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 8 ILE A 899
LEU A 819
VAL A 824
LEU A 825
 None
 1.02A 4r38B-2iv8A:
1.9		 4r38B-2iv8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 8 MET A 740
PHE A 742
ALA A 720
LEU A 723
 None
 1.02A 4rkuA-2iv8A:
undetectable
4rkuJ-2iv8A:
undetectable		 4rkuA-2iv8A:
13.43
4rkuJ-2iv8A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 7 MET A 740
PHE A 742
ALA A 720
LEU A 723
 None
 1.12A 4xk8A-2iv8A:
undetectable		 4xk8A-2iv8A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 PHE A 762
GLU A 922
VAL A 923
ILE A 927
PHE A 826
 None
 0.94A 5hkgA-2iv8A:
undetectable		 5hkgA-2iv8A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2iv8 AP-2 COMPLEX SUBUNIT
BETA-1
(Homo
sapiens) 		3 / 3 LYS A 721
LEU A 776
ILE A 725
 None
 0.65A 5kc4A-2iv8A:
undetectable		 5kc4A-2iv8A:
24.18