SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ivd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 7 THR A 181
THR A 166
GLY A 171
ASP A 172
 None
 0.75A 1bu5A-2ivdA:
5.8		 1bu5A-2ivdA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 THR A 181
THR A 166
GLY A 171
ASP A 172
 None
 0.76A 1bu5B-2ivdA:
5.8		 1bu5B-2ivdA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 GLU A 389
ARG A 339
ARG A 340
LEU A 385
 None
 0.95A 1cmaA-2ivdA:
undetectable
1cmaB-2ivdA:
undetectable		 1cmaA-2ivdA:
11.75
1cmaB-2ivdA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 ALA A 239
THR A  50
LEU A 230
LEU A  22
LEU A  81
 None
 1.16A 1eiiA-2ivdA:
undetectable		 1eiiA-2ivdA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 PHE A 331
LEU A 385
LEU A 382
VAL A 314
ALA A 344
 None
 1.20A 1gseA-2ivdA:
undetectable		 1gseA-2ivdA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 4 SER A 194
PHE A 132
GLU A 130
GLY A 129
 None
 1.44A 1icvA-2ivdA:
0.0
1icvB-2ivdA:
0.0		 1icvA-2ivdA:
19.21
1icvB-2ivdA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 11 ALA A 394
GLU A 389
ARG A 339
ARG A 340
LEU A 385
 None
 1.25A 1mjlA-2ivdA:
undetectable
1mjlB-2ivdA:
undetectable		 1mjlA-2ivdA:
11.78
1mjlB-2ivdA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 6 VAL A 279
GLU A 257
LEU A 254
ARG A 262
 None
 0.91A 1s8fB-2ivdA:
1.9		 1s8fB-2ivdA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 LEU A 458
ALA A 459
LEU A  28
VAL A  14
LEU A 237
 None
 1.03A 1s9pB-2ivdA:
undetectable		 1s9pB-2ivdA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 LEU A 223
GLY A 328
GLY A 330
LEU A 332
GLY A 343
 None
None
ACJ  A1465 (-3.9A)
ACJ  A1465 (-4.2A)
ACJ  A1465 ( 4.6A)
 1.21A 1y4lA-2ivdA:
undetectable		 1y4lA-2ivdA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 ARG A 250
ILE A 439
GLY A  21
PRO A 284
ALA A 287
 FAD  A1466 (-4.4A)
None
None
FAD  A1466 ( 4.4A)
FAD  A1466 (-3.5A)
 1.10A 2b7zA-2ivdA:
undetectable		 2b7zA-2ivdA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 7 ARG A 150
SER A 133
PHE A 147
GLU A 130
 None
 1.17A 2c8aA-2ivdA:
undetectable		 2c8aA-2ivdA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 6 ARG A 150
SER A 133
PHE A 147
GLU A 130
 None
 1.19A 2c8aC-2ivdA:
undetectable		 2c8aC-2ivdA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 6 ARG A  84
ILE A 234
GLN A  60
GLU A  59
 None
 1.43A 2ya7C-2ivdA:
undetectable		 2ya7C-2ivdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 SER A  64
ARG A 354
PHE A 351
ALA A 347
 FAD  A1466 (-4.4A)
None
None
None
 1.00A 3ax9B-2ivdA:
undetectable		 3ax9B-2ivdA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 10 ASP A 162
ALA A 335
VAL A 164
LEU A 144
PHE A 182
 None
 1.29A 3ay0A-2ivdA:
undetectable		 3ay0A-2ivdA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 6 ALA A 344
ILE A 345
VAL A 313
HIS A 315
 None
 1.08A 3nneG-2ivdA:
13.4		 3nneG-2ivdA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 SER A  30
LEU A  75
ALA A 455
ALA A 456
 None
 0.91A 3ns1L-2ivdA:
undetectable		 3ns1L-2ivdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 SER A  64
ARG A 354
PHE A 351
ALA A 347
 FAD  A1466 (-4.4A)
None
None
None
 0.99A 3ns1L-2ivdA:
undetectable		 3ns1L-2ivdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 ILE A 426
TYR A 443
ALA A 300
LEU A 299
 None
 0.86A 3ozwA-2ivdA:
3.2		 3ozwA-2ivdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 ALA A 282
GLY A  16
ALA A 459
HIS A 437
LEU A 436
 None
FAD  A1466 (-3.2A)
None
None
None
 1.19A 3qxyA-2ivdA:
undetectable		 3qxyA-2ivdA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		3 / 3 THR A  99
VAL A  97
GLU A 336
 None
 0.71A 3v4tA-2ivdA:
undetectable
3v4tD-2ivdA:
undetectable		 3v4tA-2ivdA:
25.29
3v4tD-2ivdA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 4 LEU A 219
ILE A  85
GLY A 221
PHE A  65
 None
 0.88A 4dc3A-2ivdA:
3.7		 4dc3A-2ivdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 LEU A 237
ALA A 459
ILE A  19
GLY A  21
GLY A  16
 None
None
None
None
FAD  A1466 (-3.2A)
 0.96A 4hfpB-2ivdA:
undetectable		 4hfpB-2ivdA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		3 / 3 ASP A 227
LEU A  57
VAL A  48
 None
 0.65A 4jecB-2ivdA:
undetectable		 4jecB-2ivdA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		3 / 3 TYR A  96
ARG A  94
SER A 105
 None
 0.84A 4khpI-2ivdA:
undetectable
4khpJ-2ivdA:
1.9		 4khpI-2ivdA:
15.84
4khpJ-2ivdA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 7 THR A 157
ARG A 149
PHE A 147
SER A 143
 None
 0.97A 4o4dA-2ivdA:
undetectable		 4o4dA-2ivdA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 12 ALA A  23
GLY A  17
GLY A  21
GLY A 440
ALA A 245
 None
FAD  A1466 ( 4.7A)
None
FAD  A1466 (-3.3A)
None
 0.96A 5c0oG-2ivdA:
undetectable		 5c0oG-2ivdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 6 ILE A 168
ALA A 180
THR A 181
VAL A 446
HIS A 419
 None
None
None
FAD  A1466 (-4.2A)
None
 1.42A 5eclD-2ivdA:
undetectable		 5eclD-2ivdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 8 ILE A 168
ALA A 180
THR A 181
VAL A 446
HIS A 419
 None
None
None
FAD  A1466 (-4.2A)
None
 1.41A 5ecnD-2ivdA:
undetectable		 5ecnD-2ivdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 HIS A 437
LEU A 458
LEU A 462
THR A  33
 None
 1.18A 5hs6A-2ivdA:
5.9		 5hs6A-2ivdA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 5 ARG A 193
LEU A 197
LEU A 131
PHE A 132
 GOL  A1468 (-4.3A)
GOL  A1468 (-4.6A)
None
None
 1.22A 5iy5P-2ivdA:
undetectable
5iy5W-2ivdA:
undetectable		 5iy5P-2ivdA:
18.24
5iy5W-2ivdA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 PRO A 110
ILE A 196
ALA A 199
ILE A 200
 None
None
None
GOL  A1467 ( 4.8A)
 0.57A 5mvmA-2ivdA:
undetectable
5mvmB-2ivdA:
undetectable		 5mvmA-2ivdA:
11.26
5mvmB-2ivdA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 8 HIS A  27
VAL A  24
LEU A 462
ALA A 461
 None
 0.78A 5tt3H-2ivdA:
undetectable		 5tt3H-2ivdA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 5 ARG A 193
LEU A 197
LEU A 131
PHE A 132
 GOL  A1468 (-4.3A)
GOL  A1468 (-4.6A)
None
None
 1.25A 5xdxC-2ivdA:
undetectable
5xdxJ-2ivdA:
undetectable		 5xdxC-2ivdA:
18.12
5xdxJ-2ivdA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		4 / 5 ARG A 193
LEU A 197
LEU A 131
PHE A 132
 GOL  A1468 (-4.3A)
GOL  A1468 (-4.6A)
None
None
 1.20A 5xdxP-2ivdA:
undetectable
5xdxW-2ivdA:
undetectable		 5xdxP-2ivdA:
18.12
5xdxW-2ivdA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ivd PROTOPORPHYRINOGEN
OXIDASE
(Myxococcus
xanthus) 		5 / 10 SER A  30
ILE A 452
ALA A  23
LEU A 237
PHE A 353
 None
 1.45A 5zjiA-2ivdA:
undetectable
5zjiJ-2ivdA:
undetectable		 5zjiA-2ivdA:
10.29
5zjiJ-2ivdA:
8.56