SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ivg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2ivg CYANATE LYASE
(Escherichia
coli) 		4 / 7 ILE A 121
ASP A 118
GLY A 117
PHE A 116
 None
 0.90A 2tsrA-2ivgA:
undetectable		 2tsrA-2ivgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2ivg CYANATE LYASE
(Escherichia
coli) 		5 / 11 LEU A  48
VAL A  43
LEU A  19
VAL A  61
ILE A  32
 None
 1.20A 2uxoB-2ivgA:
undetectable		 2uxoB-2ivgA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2ivg CYANATE LYASE
(Escherichia
coli) 		5 / 12 LEU A  48
ILE A  32
ALA A  33
THR A  36
LEU A  53
 None
 1.09A 3a50D-2ivgA:
undetectable		 3a50D-2ivgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2ivg CYANATE LYASE
(Escherichia
coli) 		5 / 9 ARG A  81
PHE A 126
THR A 145
ASP A 129
PHE A  42
 None
 1.44A 4drhB-2ivgA:
0.5		 4drhB-2ivgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 2ivg CYANATE LYASE
(Escherichia
coli) 		5 / 9 ARG A  81
PHE A 126
THR A 145
ASP A 129
PHE A  42
 None
 1.46A 4drhE-2ivgA:
undetectable		 4drhE-2ivgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2ivg CYANATE LYASE
(Escherichia
coli) 		4 / 8 ILE A 121
ASP A 118
GLY A 117
PHE A 116
 None
 0.87A 4iqqD-2ivgA:
undetectable		 4iqqD-2ivgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2ivg CYANATE LYASE
(Escherichia
coli) 		5 / 12 PRO A  89
PHE A  97
TYR A  98
LEU A 101
ILE A 144
 None
 0.98A 4pd4C-2ivgA:
undetectable		 4pd4C-2ivgA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 2ivg CYANATE LYASE
(Escherichia
coli) 		4 / 7 ILE A 121
ASP A 118
GLY A 117
PHE A 116
 None
 0.86A 5h3aA-2ivgA:
undetectable		 5h3aA-2ivgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 2ivg CYANATE LYASE
(Escherichia
coli) 		4 / 7 ILE A 121
ASP A 118
GLY A 117
PHE A 116
 None
 0.82A 5h3aB-2ivgA:
undetectable		 5h3aB-2ivgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2ivg CYANATE LYASE
(Escherichia
coli) 		4 / 8 ILE A 121
ASP A 118
GLY A 117
PHE A 116
 None
 0.89A 5nooD-2ivgA:
undetectable		 5nooD-2ivgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2ivg CYANATE LYASE
(Escherichia
coli) 		4 / 8 LEU A  75
ILE A  32
LEU A  20
ALA A  17
 None
 0.83A 5y7pC-2ivgA:
undetectable		 5y7pC-2ivgA:
22.86