SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ivp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 7 TYR A 127
HIS A 107
THR A 115
ASN A 286
 FE2  A1326 ( 4.4A)
FE2  A1326 ( 3.4A)
None
None
 1.08A 1afsA-2ivpA:
undetectable		 1afsA-2ivpA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 7 TYR A 127
HIS A 107
THR A 115
ASN A 286
 FE2  A1326 ( 4.4A)
FE2  A1326 ( 3.4A)
None
None
 1.08A 1afsB-2ivpA:
undetectable		 1afsB-2ivpA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 9 ASP A 159
GLU A 164
VAL A 175
GLY A 168
GLY A 171
 ATP  A1327 (-2.7A)
None
None
None
ATP  A1327 ( 4.4A)
 1.33A 1bcuH-2ivpA:
undetectable		 1bcuH-2ivpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 ALA A   3
LEU A  59
ALA A  58
LEU A  66
ILE A  69
 None
 0.95A 1g5yB-2ivpA:
undetectable		 1g5yB-2ivpA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 8 ASP A 281
ILE A 114
GLY A  16
ILE A  17
 None
 0.72A 1sh9A-2ivpA:
undetectable		 1sh9A-2ivpA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 8 ARG A  92
HIS A 107
SER A  75
VAL A  87
 None
FE2  A1326 ( 3.4A)
None
None
 1.02A 1u1jA-2ivpA:
undetectable		 1u1jA-2ivpA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 LEU A 126
VAL A 248
THR A 243
VAL A 240
GLY A 147
 None
 0.80A 2cbrA-2ivpA:
undetectable		 2cbrA-2ivpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		3 / 3 VAL A 254
VAL A 251
ASP A 196
 ATP  A1327 ( 3.6A)
None
None
 0.78A 2fumD-2ivpA:
undetectable		 2fumD-2ivpA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 ILE A  38
LEU A  80
GLY A 131
ASN A 132
GLN A 134
 None
None
ATP  A1327 (-3.5A)
ATP  A1327 (-4.4A)
None
 1.18A 2ycjA-2ivpA:
undetectable		 2ycjA-2ivpA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 9 ALA A 137
VAL A 145
VAL A 124
GLY A 125
ALA A 239
 None
 0.90A 2z0yA-2ivpA:
undetectable		 2z0yA-2ivpA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 4 GLY A   5
GLY A 287
GLY A  14
GLY A  16
 None
 0.59A 3bogC-2ivpA:
undetectable		 3bogC-2ivpA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 4 GLY A   5
GLY A 287
GLY A  14
GLY A  16
 None
 0.55A 3bogD-2ivpA:
undetectable		 3bogD-2ivpA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 GLU A   7
THR A   9
GLY A 252
HIS A 111
MET A 289
 None
ATP  A1327 (-4.4A)
ATP  A1327 ( 4.7A)
FE2  A1326 (-3.6A)
None
 1.48A 3ce6D-2ivpA:
undetectable		 3ce6D-2ivpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 5 ALA A  10
LEU A  84
GLY A  77
THR A 293
 ATP  A1327 ( 3.7A)
None
None
None
 0.93A 3dl9A-2ivpA:
undetectable		 3dl9A-2ivpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 11 ALA A 137
VAL A 145
GLY A 125
THR A 236
ALA A 239
 None
 0.92A 3kw2B-2ivpA:
undetectable		 3kw2B-2ivpA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		3 / 3 ARG A 261
LEU A 250
THR A 115
 None
 0.79A 3oxcA-2ivpA:
undetectable		 3oxcA-2ivpA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 GLY A   5
GLY A 287
ILE A  17
ALA A  25
PHE A  74
 None
 1.11A 4kicA-2ivpA:
undetectable		 4kicA-2ivpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 GLY A   5
GLY A 287
ILE A  17
ALA A  25
PHE A  74
 None
 1.08A 4kicB-2ivpA:
undetectable		 4kicB-2ivpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 GLY A   5
ILE A  17
ALA A  58
ALA A   3
PHE A  74
 None
 1.09A 4kicB-2ivpA:
undetectable		 4kicB-2ivpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 154
ALA A 157
ALA A 206
LEU A 202
MET A 263
 None
 1.04A 4lnwA-2ivpA:
undetectable		 4lnwA-2ivpA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 154
ALA A 157
ALA A 206
LEU A 202
MET A 263
 None
 1.05A 4lnxA-2ivpA:
undetectable		 4lnxA-2ivpA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 LEU A  84
ALA A  73
ILE A   6
ALA A  91
ILE A 290
 None
 0.95A 4o2bD-2ivpA:
undetectable		 4o2bD-2ivpA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 ILE A 154
ALA A 157
ALA A 206
LEU A 202
MET A 263
 None
 1.01A 4zo1X-2ivpA:
undetectable		 4zo1X-2ivpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 10 ALA A 157
ILE A 154
GLY A 201
LEU A 202
ALA A 228
 None
 1.35A 5ajqB-2ivpA:
undetectable		 5ajqB-2ivpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 5 ARG A 144
GLY A 140
THR A 243
GLU A 139
 None
 1.20A 5btiA-2ivpA:
undetectable
5btiB-2ivpA:
undetectable		 5btiA-2ivpA:
23.33
5btiB-2ivpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 ALA A  83
GLY A  81
ALA A  10
GLY A   8
SER A  75
 None
None
ATP  A1327 ( 3.7A)
None
None
 1.27A 5jglB-2ivpA:
undetectable		 5jglB-2ivpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 7 GLY A 104
ALA A  88
PHE A 304
ASN A 106
 None
 0.96A 5mvsA-2ivpA:
undetectable		 5mvsA-2ivpA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 8 GLY A 104
ALA A  88
PHE A 304
ASN A 106
 None
 0.96A 5mvsB-2ivpA:
undetectable		 5mvsB-2ivpA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 LEU A  84
ALA A  73
ILE A   6
ALA A  91
ILE A 290
 None
 0.99A 5xiwB-2ivpA:
2.2		 5xiwB-2ivpA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		3 / 3 ARG A 163
PHE A 169
GLY A  36
 None
 0.78A 6fgdA-2ivpA:
undetectable		 6fgdA-2ivpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		3 / 3 LYS A 245
VAL A 124
ASP A 122
 None
 0.56A 6fgdA-2ivpA:
undetectable		 6fgdA-2ivpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 8 HIS A 107
GLY A  77
LEU A  80
GLY A  81
 FE2  A1326 ( 3.4A)
None
None
None
 0.87A 6mdqA-2ivpA:
undetectable		 6mdqA-2ivpA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		4 / 8 LYS A 314
LEU A  80
GLY A  81
LEU A  84
 None
 0.79A 6mdqA-2ivpA:
undetectable		 6mdqA-2ivpA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 PHE A  74
ILE A 290
LEU A 282
GLY A  14
ALA A  25
 None
 1.10A 6r2eE-2ivpA:
undetectable		 6r2eE-2ivpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 11 PHE A  74
ILE A 290
LEU A 282
GLY A  14
ALA A  25
 None
 1.10A 6r2eF-2ivpA:
undetectable		 6r2eF-2ivpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE
(Pyrococcus
abyssi) 		5 / 12 PHE A  74
ILE A 290
LEU A 282
GLY A  14
ALA A  25
 None
 1.20A 6r2eH-2ivpA:
undetectable		 6r2eH-2ivpA:
22.81