SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 10 GLY A 102
THR A 233
HIS A  99
THR A  71
GLY A  98
 None
 1.02A 1c9sN-2iw0A:
undetectable
1c9sO-2iw0A:
undetectable		 1c9sN-2iw0A:
14.57
1c9sO-2iw0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 9 GLY A 102
THR A 233
HIS A  99
THR A  71
GLY A  98
 None
 1.06A 1c9sQ-2iw0A:
undetectable
1c9sR-2iw0A:
undetectable		 1c9sQ-2iw0A:
14.57
1c9sR-2iw0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 10 GLY A  98
GLY A 102
THR A 233
HIS A  99
THR A  71
 None
 1.04A 1c9sL-2iw0A:
undetectable
1c9sV-2iw0A:
undetectable		 1c9sL-2iw0A:
14.57
1c9sV-2iw0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 9 GLY A  98
GLY A 102
THR A 233
HIS A  99
THR A  71
 None
 0.99A 1gtfD-2iw0A:
undetectable
1gtfE-2iw0A:
undetectable		 1gtfD-2iw0A:
14.57
1gtfE-2iw0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 12 GLY A  98
GLY A 102
THR A 233
HIS A  99
THR A  71
 None
 1.03A 1gtnL-2iw0A:
undetectable
1gtnV-2iw0A:
undetectable		 1gtnL-2iw0A:
14.57
1gtnV-2iw0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 LYS A  64
ILE A 221
THR A 233
 None
 0.85A 1rx3A-2iw0A:
undetectable		 1rx3A-2iw0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 10 GLY A 102
THR A 233
HIS A  99
THR A  71
GLY A  98
 None
 1.06A 1utdE-2iw0A:
undetectable
1utdF-2iw0A:
undetectable		 1utdE-2iw0A:
14.57
1utdF-2iw0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 LEU A 220
PHE A 188
ARG A 230
 None
 0.64A 1xdkB-2iw0A:
undetectable		 1xdkB-2iw0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 LEU A 220
PHE A 188
ARG A 230
 None
 0.64A 1xdkF-2iw0A:
undetectable		 1xdkF-2iw0A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 TRP A 245
LEU A 238
LYS A  29
 None
 1.28A 1yajK-2iw0A:
undetectable		 1yajK-2iw0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		4 / 7 ASP A  50
HIS A 108
LEU A 204
ILE A 163
 ZN  A1255 ( 2.5A)
ZN  A1255 ( 3.2A)
None
None
 0.88A 3avpA-2iw0A:
undetectable		 3avpA-2iw0A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 11 ALA A 143
ARG A 142
PHE A  73
ILE A  35
PRO A  34
 None
 1.28A 3bpxA-2iw0A:
undetectable
3bpxB-2iw0A:
undetectable		 3bpxA-2iw0A:
19.60
3bpxB-2iw0A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		4 / 7 LYS A  29
LEU A  43
VAL A 232
LEU A 100
 None
 0.92A 3rgfA-2iw0A:
undetectable		 3rgfA-2iw0A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		4 / 8 PHE A  72
ILE A  62
THR A 212
THR A 217
 None
 0.84A 4em2A-2iw0A:
undetectable		 4em2A-2iw0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 LYS A  64
ILE A 221
THR A 233
 None
 0.87A 4gh8A-2iw0A:
undetectable		 4gh8A-2iw0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		4 / 7 LEU A 168
ASN A 167
LEU A  46
ILE A 164
 None
 1.04A 4okwA-2iw0A:
undetectable		 4okwA-2iw0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 MET A 141
GLN A 125
TYR A 106
 None
 1.04A 4udcA-2iw0A:
undetectable		 4udcA-2iw0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		4 / 7 VAL A  74
ILE A 133
HIS A  99
LEU A  60
 None
 1.24A 4xo7B-2iw0A:
4.3		 4xo7B-2iw0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 12 THR A  47
GLY A  51
ILE A  82
ALA A  80
ASP A 207
 None
 1.15A 5kvaA-2iw0A:
undetectable		 5kvaA-2iw0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 12 THR A  47
GLY A  51
ILE A  82
ALA A  80
ASP A 207
 None
 1.16A 5kvaB-2iw0A:
undetectable		 5kvaB-2iw0A:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 6 ASP A  49
ASP A  50
HIS A 104
HIS A 108
HIS A 206
 ACT  A1256 (-3.5A)
ZN  A1255 ( 2.5A)
ZN  A1255 ( 3.3A)
ZN  A1255 ( 3.2A)
ACT  A1256 (-4.3A)
 0.20A 5ncdA-2iw0A:
23.9
5ncdD-2iw0A:
24.3		 5ncdA-2iw0A:
30.45
5ncdD-2iw0A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 6 ASP A  49
ASP A  50
HIS A 104
HIS A 108
HIS A 206
 ACT  A1256 (-3.5A)
ZN  A1255 ( 2.5A)
ZN  A1255 ( 3.3A)
ZN  A1255 ( 3.2A)
ACT  A1256 (-4.3A)
 0.25A 5ncdB-2iw0A:
24.3
5ncdC-2iw0A:
24.1		 5ncdB-2iw0A:
30.45
5ncdC-2iw0A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		4 / 4 ASP A  49
HIS A 104
HIS A 108
HIS A 206
 ACT  A1256 (-3.5A)
ZN  A1255 ( 3.3A)
ZN  A1255 ( 3.2A)
ACT  A1256 (-4.3A)
 0.12A 5ncdD-2iw0A:
24.3		 5ncdD-2iw0A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		6 / 8 ASP A  49
ASP A  50
HIS A 104
HIS A 108
PRO A 144
HIS A 206
 ACT  A1256 (-3.5A)
ZN  A1255 ( 2.5A)
ZN  A1255 ( 3.3A)
ZN  A1255 ( 3.2A)
ACT  A1256 (-4.5A)
ACT  A1256 (-4.3A)
 0.32A 5nekB-2iw0A:
24.2		 5nekB-2iw0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 8 ASP A  49
ASP A  50
HIS A 104
HIS A 108
HIS A 206
 ACT  A1256 (-3.5A)
ZN  A1255 ( 2.5A)
ZN  A1255 ( 3.3A)
ZN  A1255 ( 3.2A)
ACT  A1256 (-4.3A)
 0.39A 5nekD-2iw0A:
24.3		 5nekD-2iw0A:
17.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 6 ASP A  49
ASP A  50
HIS A 104
HIS A 108
HIS A 206
 ACT  A1256 (-3.5A)
ZN  A1255 ( 2.5A)
ZN  A1255 ( 3.3A)
ZN  A1255 ( 3.2A)
ACT  A1256 (-4.3A)
 0.24A 5nelA-2iw0A:
24.1
5nelD-2iw0A:
24.2		 5nelA-2iw0A:
30.45
5nelD-2iw0A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		5 / 6 ASP A  49
HIS A 104
HIS A 108
LEU A 204
HIS A 206
 ACT  A1256 (-3.5A)
ZN  A1255 ( 3.3A)
ZN  A1255 ( 3.2A)
None
ACT  A1256 (-4.3A)
 0.25A 5nelB-2iw0A:
24.3
5nelC-2iw0A:
24.1		 5nelB-2iw0A:
30.45
5nelC-2iw0A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 HIS A 251
HIS A 254
ARG A 124
 PO4  A1260 (-3.9A)
PO4  A1260 (-3.9A)
PO4  A1260 ( 3.5A)
 1.02A 6b58A-2iw0A:
2.6		 6b58A-2iw0A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 2iw0 CHITIN DEACETYLASE
(Colletotrichum
lindemuthianum) 		3 / 3 ARG A  92
ARG A  95
ASP A 134
 None
 0.68A 6d8pA-2iw0A:
undetectable		 6d8pA-2iw0A:
15.15