SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 8 GLY A  92
THR A 131
GLY A  86
LEU A 140
 None
 0.86A 1aegA-2iw1A:
undetectable		 1aegA-2iw1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		3 / 3 GLN A 324
TYR A 279
ARG A 208
 None
None
U2F  A 900 (-3.0A)
 0.82A 1gtbA-2iw1A:
undetectable		 1gtbA-2iw1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 9 LEU A 275
LEU A 231
LEU A 221
GLU A 329
ALA A 217
 None
 1.17A 1sn0A-2iw1A:
undetectable
1sn0C-2iw1A:
undetectable		 1sn0A-2iw1A:
16.80
1sn0C-2iw1A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 12 LEU A 275
LEU A 231
LEU A 221
GLU A 329
ALA A 217
 None
 1.12A 1sn5B-2iw1A:
undetectable
1sn5D-2iw1A:
undetectable		 1sn5B-2iw1A:
16.80
1sn5D-2iw1A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		3 / 3 GLY A  63
GLU A  67
ASN A  61
 None
 0.73A 1zq9A-2iw1A:
4.4		 1zq9A-2iw1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 11 LEU A 221
LEU A 218
ASN A 197
LEU A 331
ARG A 341
 None
 0.98A 2ceoA-2iw1A:
undetectable		 2ceoA-2iw1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 7 ALA A 125
TYR A 121
TYR A 103
TYR A 155
 None
 1.07A 2pncA-2iw1A:
undetectable		 2pncA-2iw1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 5 LEU A 357
PRO A 167
LEU A 288
ILE A 291
 None
 0.77A 2qd4A-2iw1A:
4.0		 2qd4A-2iw1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 10 LEU A 218
LEU A 199
ASN A 197
LEU A 331
ARG A 341
 None
 1.20A 2riwA-2iw1A:
undetectable
2riwB-2iw1A:
undetectable		 2riwA-2iw1A:
20.45
2riwB-2iw1A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 10 LEU A 221
LEU A 218
ASN A 197
LEU A 331
ARG A 341
 None
 1.05A 2riwA-2iw1A:
undetectable
2riwB-2iw1A:
undetectable		 2riwA-2iw1A:
20.45
2riwB-2iw1A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 10 LEU A 221
LEU A 218
ASN A 197
LEU A 331
ARG A 341
 None
 1.01A 2xn7A-2iw1A:
undetectable
2xn7B-2iw1A:
undetectable		 2xn7A-2iw1A:
20.34
2xn7B-2iw1A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 10 LEU A 200
VAL A 297
GLY A 284
ILE A 285
LEU A 274
 None
None
U2F  A 900 (-3.6A)
U2F  A 900 (-3.6A)
None
 1.06A 3ogpB-2iw1A:
undetectable		 3ogpB-2iw1A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 4 LEU A 357
PRO A 167
LEU A 288
ILE A 291
 None
 0.86A 4f4dB-2iw1A:
4.0		 4f4dB-2iw1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 8 GLY A  15
TYR A 308
LEU A 288
TYR A 170
 U2F  A 900 (-3.2A)
None
None
None
 0.82A 4fgzA-2iw1A:
3.0		 4fgzA-2iw1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 8 GLY A  15
TYR A 308
LEU A 288
TYR A 170
 U2F  A 900 (-3.2A)
None
None
None
 0.81A 4fgzB-2iw1A:
3.0		 4fgzB-2iw1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		3 / 3 ASP A 272
LEU A 275
VAL A 234
 None
None
U2F  A 900 (-4.6A)
 0.55A 4jecB-2iw1A:
undetectable		 4jecB-2iw1A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 5 TYR A 155
ASP A 100
GLU A 105
VAL A 302
 None
 1.24A 4nkvA-2iw1A:
undetectable		 4nkvA-2iw1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 5 TYR A 155
ASP A 100
GLU A 105
VAL A 302
 None
 1.26A 4nkvB-2iw1A:
undetectable		 4nkvB-2iw1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 6 GLU A  50
ILE A   2
HIS A  79
TYR A  37
 None
 1.42A 4qwpA-2iw1A:
undetectable		 4qwpA-2iw1A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 8 PHE A 151
ARG A 129
ALA A 125
PHE A  11
 None
 1.01A 4rkuA-2iw1A:
undetectable
4rkuJ-2iw1A:
undetectable		 4rkuA-2iw1A:
18.85
4rkuJ-2iw1A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 12 GLY A 203
LEU A 245
ALA A 278
GLY A 210
SER A 214
 U2F  A 900 ( 4.3A)
None
None
None
None
 1.41A 5jglB-2iw1A:
2.0		 5jglB-2iw1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 8 VAL A  85
ILE A  23
ALA A 365
THR A 369
VAL A   3
 None
 1.49A 5l94A-2iw1A:
undetectable		 5l94A-2iw1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		5 / 8 VAL A  95
ILE A 367
ALA A 365
THR A 369
VAL A   3
 None
 1.50A 5l94A-2iw1A:
undetectable		 5l94A-2iw1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 7 LEU A 298
LEU A 327
ALA A 217
THR A 229
 None
 0.78A 6a7jA-2iw1A:
undetectable		 6a7jA-2iw1A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 2iw1 LIPOPOLYSACCHARIDE
CORE BIOSYNTHESIS
PROTEIN RFAG
(Escherichia
coli) 		4 / 5 GLU A 160
PRO A 159
THR A 157
GLN A 134
 None
 1.23A 6fgdA-2iw1A:
2.7		 6fgdA-2iw1A:
21.95