SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 ASP A 194
VAL A  33
ILE A 255
PHE A 253
ILE A 196
 None
 1.11A 1c9hA-2iwaA:
undetectable		 1c9hA-2iwaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		3 / 3 LEU A 179
LEU A 141
MET A 128
 None
 0.78A 1ya3B-2iwaA:
undetectable		 1ya3B-2iwaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 6 GLU A  52
ASP A 236
PHE A 243
ARG A 241
 NAG  A 502 (-3.8A)
None
None
None
 1.39A 2a3bB-2iwaA:
undetectable		 2a3bB-2iwaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		3 / 3 VAL A 103
TRP A 105
TRP A 132
 None
 1.28A 2xdcC-2iwaA:
undetectable
2xdcD-2iwaA:
undetectable		 2xdcC-2iwaA:
5.94
2xdcD-2iwaA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 7 ARG A  27
ASN A 169
GLY A 170
VAL A 173
 None
 0.88A 2y05A-2iwaA:
undetectable
2y05B-2iwaA:
undetectable		 2y05A-2iwaA:
20.99
2y05B-2iwaA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		3 / 3 GLY A 133
GLY A  47
GLY A  92
 None
 0.42A 3bogC-2iwaA:
undetectable		 3bogC-2iwaA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		3 / 3 GLY A 133
GLY A  47
GLY A  92
 None
 0.30A 3bogD-2iwaA:
undetectable		 3bogD-2iwaA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 LEU A  56
THR A  55
ALA A  51
LEU A 100
LEU A  95
 None
 1.11A 3hm1A-2iwaA:
undetectable		 3hm1A-2iwaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_2
(GENOME POLYPROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 4 GLN A  46
PHE A  44
TYR A  63
VAL A  78
 None
 1.42A 3keeA-2iwaA:
0.0		 3keeA-2iwaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 7 ILE A 210
LEU A 212
ILE A 233
ASN A 189
 None
 0.94A 3p50A-2iwaA:
undetectable		 3p50A-2iwaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 7 ILE A 210
LEU A 212
ILE A 233
ASN A 189
 None
 0.94A 3p50B-2iwaA:
undetectable		 3p50B-2iwaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 7 ILE A 210
LEU A 212
ILE A 233
ASN A 189
 None
 0.93A 3p50C-2iwaA:
undetectable		 3p50C-2iwaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 7 ILE A 210
LEU A 212
ILE A 233
ASN A 189
 None
 0.94A 3p50D-2iwaA:
undetectable		 3p50D-2iwaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 7 ILE A 210
LEU A 212
ILE A 233
ASN A 189
 None
 0.93A 3p50E-2iwaA:
undetectable		 3p50E-2iwaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 PHE A 111
LEU A  48
VAL A  71
SER A  67
MET A  84
 NAG  A 503 (-4.7A)
None
None
None
None
 1.48A 4a84A-2iwaA:
undetectable		 4a84A-2iwaA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		4 / 5 GLY A 208
LEU A 176
LEU A 274
LEU A 212
 None
 0.72A 4o8fA-2iwaA:
undetectable		 4o8fA-2iwaA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 ALA A  51
THR A  60
GLN A  46
PHE A  57
GLY A  47
 None
 1.29A 5hfjB-2iwaA:
undetectable		 5hfjB-2iwaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 ALA A  51
THR A  60
GLN A  46
PHE A  57
GLY A  47
 None
 1.20A 5hfjC-2iwaA:
undetectable		 5hfjC-2iwaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 ALA A  51
THR A  60
GLN A  46
PHE A  57
GLY A  47
 None
 1.13A 5hfjF-2iwaA:
undetectable		 5hfjF-2iwaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 GLY A  61
LEU A  62
ASP A  40
THR A  45
GLN A  46
 None
None
GOL  A 505 (-4.3A)
None
None
 1.23A 5hg0A-2iwaA:
undetectable		 5hg0A-2iwaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 ASP A 194
VAL A  33
ILE A 255
PHE A 253
ILE A 196
 None
 1.06A 5hkgA-2iwaA:
undetectable		 5hkgA-2iwaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 12 ASP A 194
VAL A  33
ILE A 255
PHE A 253
ILE A 210
 None
 1.19A 5hkgA-2iwaA:
undetectable		 5hkgA-2iwaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 2iwa GLUTAMINE
CYCLOTRANSFERASE
(Carica
papaya) 		5 / 11 ASP A 194
VAL A  33
ILE A 255
ILE A 210
ILE A 196
 None
 1.26A 5hw8G-2iwaA:
undetectable		 5hw8G-2iwaA:
20.38