SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		3 / 3 VAL A 115
TRP A 105
TRP A  88
 None
 1.04A 1c4dA-2iwiA:
undetectable
1c4dB-2iwiA:
undetectable		 1c4dA-2iwiA:
5.41
1c4dB-2iwiA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		7 / 12 LEU A  38
GLY A  39
VAL A  46
ALA A  59
ASN A 168
LEU A 170
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.7A)
HB1  A1289 (-4.2A)
 0.68A 1fmoE-2iwiA:
26.7		 1fmoE-2iwiA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 10 GLY A 145
VAL A 147
LEU A 224
LEU A 277
ALA A 150
 None
 1.09A 1pbcA-2iwiA:
undetectable		 1pbcA-2iwiA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 8 ALA A 219
TRP A 208
TYR A 214
GLY A 199
 None
 0.73A 1rukH-2iwiA:
undetectable
1rukL-2iwiA:
undetectable		 1rukH-2iwiA:
20.31
1rukL-2iwiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 4 LEU A 277
PRO A 205
ILE A 164
LEU A 224
 None
 1.10A 1ya4B-2iwiA:
undetectable		 1ya4B-2iwiA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		9 / 10 LEU A  38
PHE A  43
ALA A  59
ILE A 100
LEU A 116
PRO A 119
ASP A 124
LEU A 170
ILE A 181
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.9A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
 0.62A 1yi4A-2iwiA:
25.5		 1yi4A-2iwiA:
54.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		7 / 12 LEU A  38
VAL A  46
ALA A  59
ASP A 163
LYS A 165
ASN A 168
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.2A)
 0.83A 2fumA-2iwiA:
26.0		 2fumA-2iwiA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 LEU A  38
GLY A  39
VAL A  46
GLU A  83
LEU A  87
LEU A 114
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
None
None
None
 0.50A 2ivuA-2iwiA:
25.3		 2ivuA-2iwiA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 4 ARG A 101
GLY A  98
GLU A 117
SER A 156
 None
 1.24A 2xctS-2iwiA:
2.7
2xctU-2iwiA:
undetectable		 2xctS-2iwiA:
18.13
2xctU-2iwiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 VAL A  46
ALA A  59
GLU A  83
LEU A  86
LEU A  87
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
None
None
 0.86A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 VAL A  46
ALA A  59
GLU A  83
LEU A  87
ILE A 100
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 (-4.1A)
None
 0.93A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 8 VAL A  46
ILE A 100
ILE A 181
ASP A 182
 HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.71A 3warA-2iwiA:
24.4		 3warA-2iwiA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 LEU A  38
GLY A  39
VAL A  46
ALA A  59
GLU A  83
LEU A  87
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
 0.87A 3wzdA-2iwiA:
16.3		 3wzdA-2iwiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 12 LEU A  38
VAL A  46
ALA A  59
GLU A  83
LEU A  87
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 (-4.7A)
 0.58A 4agcA-2iwiA:
21.0		 4agcA-2iwiA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		6 / 10 LEU A  38
GLY A  39
GLY A  41
VAL A  46
ALA A  59
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.7A)
 0.60A 4ckjA-2iwiA:
25.1		 4ckjA-2iwiA:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		12 / 12 PHE A  43
VAL A  46
ALA A  59
ILE A 100
ASP A 124
ASP A 127
ASP A 163
LYS A 165
ASN A 168
LEU A 170
ILE A 181
ASP A 182
 HB1  A1289 (-3.9A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.6A)
None
None
None
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.61A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 4 LEU A  38
LEU A 116
GLN A 123
GLU A 167
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.7A)
 0.75A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		9 / 12 ILE A 129
THR A 130
ASP A 166
THR A 200
VAL A 202
ASP A 230
ASP A 235
ILE A 236
GLU A 243
 None
 0.86A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		9 / 12 ILE A 129
THR A 130
ASP A 166
VAL A 202
ASP A 230
ASP A 235
ILE A 236
GLU A 239
GLU A 243
 None
 0.85A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		8 / 12 ILE A 129
THR A 130
LYS A 165
ASP A 166
ASP A 230
ASP A 235
ILE A 236
GLU A 239
 None
 0.80A 4i41A-2iwiA:
36.6		 4i41A-2iwiA:
55.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		7 / 11 PHE A  43
LEU A 116
ASP A 124
GLU A 167
LEU A 170
ILE A 181
ASP A 182
 HB1  A1289 (-3.9A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.87A 4iaaA-2iwiA:
36.3		 4iaaA-2iwiA:
56.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		8 / 11 PHE A  43
VAL A  46
ALA A  59
LEU A 116
ASP A 124
LEU A 170
ILE A 181
ASP A 182
 HB1  A1289 (-3.9A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.7A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.76A 4iaaA-2iwiA:
36.3		 4iaaA-2iwiA:
56.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 12 ALA A 187
PHE A 183
THR A 220
ILE A 164
LEU A 180
 None
 1.06A 4nx7A-2iwiA:
undetectable		 4nx7A-2iwiA:
16.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 6 LEU A  38
GLY A  39
VAL A  46
ALA A  59
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.7A)
 0.76A 4o0wA-2iwiA:
23.0		 4o0wA-2iwiA:
31.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 8 VAL A  46
ALA A  59
ASP A 124
ASN A 168
ASP A 182
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 4.9A)
HB1  A1289 (-4.2A)
 0.60A 4ogrA-2iwiA:
16.9		 4ogrA-2iwiA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 8 LEU A  38
VAL A  46
ALA A 122
HIS A 161
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 4.4A)
None
HB1  A1289 (-4.7A)
 1.19A 4qrcA-2iwiA:
22.0		 4qrcA-2iwiA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 8 LEU A  38
VAL A  46
ILE A 100
HIS A 161
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
None
HB1  A1289 (-4.7A)
 0.70A 4qrcA-2iwiA:
22.0		 4qrcA-2iwiA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 11 ILE A 171
GLY A 176
CYH A 177
ALA A 178
VAL A 147
 None
 1.35A 5hw4B-2iwiA:
undetectable		 5hw4B-2iwiA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 7 GLY A  39
GLY A  41
VAL A  46
ASP A 182
 HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.6A)
HB1  A1289 (-4.2A)
 0.45A 5j5xA-2iwiA:
21.3		 5j5xA-2iwiA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 12 ILE A 164
LEU A 180
SER A 185
GLY A 186
HIS A 155
 None
 1.24A 5nnaA-2iwiA:
undetectable		 5nnaA-2iwiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 12 ILE A 164
LEU A 180
SER A 185
GLY A 186
HIS A 155
 None
 1.23A 5nnaB-2iwiA:
undetectable		 5nnaB-2iwiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 8 VAL A  99
HIS A 153
GLN A 146
GLY A 145
 None
 0.86A 5w3jB-2iwiA:
undetectable		 5w3jB-2iwiA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		5 / 9 LEU A  38
VAL A  46
ILE A 100
ILE A 181
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.87A 5yf9X-2iwiA:
24.4		 5yf9X-2iwiA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens) 		4 / 7 VAL A  46
ILE A 100
ILE A 181
ASP A 182
 HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.48A 5ywmX-2iwiA:
24.4		 5ywmX-2iwiA:
14.18