SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2iwn MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 387
GLY A 388
ILE A 389
ILE A 391
VAL A 445
 None
 0.56A 2kawA-2iwnA:
13.4		 2kawA-2iwnA:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2iwn MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 387
GLY A 388
ILE A 391
VAL A 445
LEU A 448
 None
 0.77A 2kawA-2iwnA:
13.4		 2kawA-2iwnA:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2iwn MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 8 VAL A 378
LEU A 380
ILE A 410
VAL A 407
 None
 0.84A 5nujA-2iwnA:
undetectable		 5nujA-2iwnA:
18.18