SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A1879
THR A1893
ILE A1888
LEU A1905
ILE A1862
 None
 0.99A 1rd7A-2iwoA:
undetectable		 1rd7A-2iwoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A1879
THR A1893
ILE A1888
LEU A1905
ILE A1862
 None
 0.97A 1rd7B-2iwoA:
undetectable		 1rd7B-2iwoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A1879
THR A1893
ILE A1888
LEU A1905
ILE A1862
 None
 1.01A 1rx7A-2iwoA:
undetectable		 1rx7A-2iwoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A1845
GLY A1846
ILE A1847
SER A1848
ILE A1849
 None
 0.60A 2kawA-2iwoA:
11.6		 2kawA-2iwoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 THR A1876
MET A1837
ILE A1912
LEU A1845
ILE A1847
 None
 1.26A 3a50B-2iwoA:
undetectable		 3a50B-2iwoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 THR A1876
MET A1837
ILE A1912
LEU A1845
ILE A1847
 None
 1.27A 3a50C-2iwoA:
undetectable		 3a50C-2iwoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 THR A1876
MET A1837
ILE A1912
LEU A1845
ILE A1847
 None
 1.28A 3a50E-2iwoA:
undetectable		 3a50E-2iwoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 THR A1876
MET A1837
ILE A1912
LEU A1845
ILE A1847
 None
 1.24A 3a51A-2iwoA:
undetectable		 3a51A-2iwoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 THR A1899
ILE A1862
GLY A1851
HIS A1898
LEU A1904
 None
 1.09A 3eeyB-2iwoA:
undetectable		 3eeyB-2iwoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 12 THR A1899
ILE A1862
GLY A1851
HIS A1898
LEU A1904
 None
 1.08A 3eeyD-2iwoA:
undetectable		 3eeyD-2iwoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A1879
THR A1893
ILE A1888
LEU A1905
ILE A1862
 None
 1.02A 3tqbA-2iwoA:
undetectable		 3tqbA-2iwoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2iwo MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		3 / 3 GLY A1846
VAL A1835
MET A1914
 None
 0.65A 5ycpA-2iwoA:
undetectable		 5ycpA-2iwoA:
21.85