SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 2iwq MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 4 ARG A1150
LEU A1202
ASN A1199
VAL A1239
 None
 1.37A 1lqtA-2iwqA:
undetectable		 1lqtA-2iwqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 2iwq MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 4 ARG A1150
LEU A1202
ASN A1199
VAL A1239
 None
 1.40A 1lqtB-2iwqA:
undetectable		 1lqtB-2iwqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 2iwq MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 4 ARG A1150
LEU A1202
ASN A1199
VAL A1239
 None
 1.38A 1lquA-2iwqA:
undetectable		 1lquA-2iwqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 2iwq MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 4 ARG A1150
LEU A1202
ASN A1199
VAL A1239
 None
 1.41A 1lquB-2iwqA:
undetectable		 1lquB-2iwqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2iwq MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A1202
ILE A1208
ILE A1164
ILE A1166
 None
 0.82A 2bu8A-2iwqA:
undetectable		 2bu8A-2iwqA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2iwq MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		5 / 11 GLY A1163
ILE A1164
SER A1165
VAL A1225
ARG A1229
 None
 0.80A 2kawA-2iwqA:
11.9		 2kawA-2iwqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2iwq MULTIPLE PDZ DOMAIN
PROTEIN
(Homo
sapiens) 		6 / 11 LEU A1162
GLY A1163
ILE A1164
SER A1165
ILE A1166
VAL A1225
 None
 0.93A 2kawA-2iwqA:
11.9		 2kawA-2iwqA:
22.76