SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2iwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 217
ALA A 233
GLY A 234
HIS A 203
ALA A 149
 None
 0.90A 1bx4A-2iwzA:
undetectable		 1bx4A-2iwzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 212
VAL A 216
ALA A 208
SER A 444
HIS A 348
 None
None
6NA  A1460 (-3.4A)
NH4  A1461 ( 4.4A)
None
 1.35A 1kiaD-2iwzA:
undetectable		 1kiaD-2iwzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 212
VAL A 216
ALA A 208
SER A 444
HIS A 348
 None
None
6NA  A1460 (-3.4A)
NH4  A1461 ( 4.4A)
None
 1.33A 1nbhA-2iwzA:
undetectable		 1nbhA-2iwzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 212
VAL A 216
ALA A 208
SER A 444
HIS A 348
 None
None
6NA  A1460 (-3.4A)
NH4  A1461 ( 4.4A)
None
 1.33A 1nbhC-2iwzA:
undetectable		 1nbhC-2iwzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 212
VAL A 216
ALA A 208
SER A 444
HIS A 348
 None
None
6NA  A1460 (-3.4A)
NH4  A1461 ( 4.4A)
None
 1.34A 1nbhD-2iwzA:
undetectable		 1nbhD-2iwzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A 280
VAL A 393
HIS A 348
HIS A 385
THR A 383
 None
 1.05A 1r55A-2iwzA:
undetectable		 1r55A-2iwzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A 281
THR A 379
HIS A 348
HIS A 385
THR A 383
 None
 1.22A 1r55A-2iwzA:
undetectable		 1r55A-2iwzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 7 LEU A 454
GLY A 391
VAL A 205
ASP A 218
 None
 0.96A 1t88A-2iwzA:
undetectable		 1t88A-2iwzA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLU A 394
HIS A 348
ALA A 452
GLY A 388
GLY A 391
 NH4  A1461 (-3.7A)
None
None
None
None
 1.08A 1x1aA-2iwzA:
undetectable		 1x1aA-2iwzA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 0.90A 2aquA-2iwzA:
undetectable		 2aquA-2iwzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A  48
ARG A 294
ASP A 132
ALA A 129
ALA A 126
 None
 1.01A 2br4A-2iwzA:
undetectable		 2br4A-2iwzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 6 ALA A 382
VAL A 393
GLU A 394
PHE A 397
 None
None
NH4  A1461 (-3.7A)
None
 0.90A 2cizA-2iwzA:
undetectable		 2cizA-2iwzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 8 GLY A 391
GLY A 235
THR A 236
ALA A 280
ALA A 281
 None
 1.38A 2ej3C-2iwzA:
undetectable		 2ej3C-2iwzA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 234
GLY A 212
HIS A 214
ALA A 280
ALA A 126
 None
 0.98A 2gluA-2iwzA:
undetectable		 2gluA-2iwzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		6 / 12 GLY A 212
GLY A 388
THR A 207
ALA A 281
ALA A 395
ALA A 215
 None
 1.47A 2gluB-2iwzA:
undetectable		 2gluB-2iwzA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 9 ARG A  94
GLY A  95
THR A 236
VAL A  92
PRO A  93
 None
 1.33A 2nnhB-2iwzA:
undetectable		 2nnhB-2iwzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 234
GLY A 212
ALA A 280
HIS A 203
VAL A 192
 None
 0.84A 2yqzB-2iwzA:
undetectable		 2yqzB-2iwzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 0.90A 2z54A-2iwzA:
undetectable		 2z54A-2iwzA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 0.93A 2z54B-2iwzA:
undetectable		 2z54B-2iwzA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 234
GLY A 212
ALA A 280
ALA A 126
ALA A 204
 None
 1.05A 3g88A-2iwzA:
undetectable		 3g88A-2iwzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 234
GLY A 212
ALA A 280
ALA A 126
ALA A 204
 None
 1.05A 3g88B-2iwzA:
undetectable		 3g88B-2iwzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 234
GLY A 212
ALA A 280
ALA A 126
ALA A 204
 None
 1.07A 3g89A-2iwzA:
undetectable		 3g89A-2iwzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A 234
GLY A 212
ALA A 280
ALA A 126
ALA A 204
 None
 1.06A 3g89B-2iwzA:
undetectable		 3g89B-2iwzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 234
GLY A 212
ALA A 280
ALA A 126
ALA A 204
 None
 1.05A 3g8bB-2iwzA:
undetectable		 3g8bB-2iwzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		6 / 12 LEU A 454
GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 1.32A 3jw2B-2iwzA:
undetectable		 3jw2B-2iwzA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		6 / 12 ALA A 281
ALA A 122
ALA A 125
ALA A 213
GLY A 212
ALA A 389
 None
 1.37A 3mg0Y-2iwzA:
undetectable
3mg0Z-2iwzA:
undetectable		 3mg0Y-2iwzA:
19.09
3mg0Z-2iwzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 0.89A 3ndxA-2iwzA:
undetectable		 3ndxA-2iwzA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 THR A 383
PHE A 267
ILE A 363
ALA A 362
ALA A 452
 None
 1.09A 3nxuB-2iwzA:
undetectable		 3nxuB-2iwzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A 386
ALA A 349
GLY A  72
PRO A  54
 None
 0.89A 3ny4A-2iwzA:
undetectable		 3ny4A-2iwzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		3 / 3 TYR A  81
TYR A  91
GLU A 158
 None
 0.94A 3pfgA-2iwzA:
undetectable		 3pfgA-2iwzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 7 ALA A 129
GLY A 234
ILE A 150
THR A 146
 None
 0.87A 3spkB-2iwzA:
undetectable		 3spkB-2iwzA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A 445
GLY A 446
ALA A 357
GLU A 419
ASN A 360
 None
6NA  A1460 (-3.3A)
None
None
None
 1.23A 3v3oB-2iwzA:
undetectable		 3v3oB-2iwzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		3 / 3 GLY A 446
THR A 210
ASN A 451
 6NA  A1460 (-3.3A)
None
None
 0.73A 3v4tD-2iwzA:
undetectable		 3v4tD-2iwzA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 MET A 130
GLY A 134
VAL A 232
PRO A 137
LEU A 198
 None
 1.04A 3v8vA-2iwzA:
undetectable		 3v8vA-2iwzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 0.97A 4dqbB-2iwzA:
undetectable		 4dqbB-2iwzA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 0.98A 4dqeB-2iwzA:
undetectable		 4dqeB-2iwzA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A 234
ALA A 233
GLY A  48
ILE A  49
VAL A 302
 None
 0.96A 4dqhB-2iwzA:
undetectable		 4dqhB-2iwzA:
13.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		10 / 12 GLY A 153
ALA A 208
CYH A 209
PHE A 248
HIS A 348
THR A 350
HIS A 385
LEU A 387
GLY A 446
PHE A 447
 6NA  A1460 (-3.5A)
6NA  A1460 (-3.4A)
6NA  A1460 (-1.7A)
6NA  A1460 (-4.9A)
None
None
None
6NA  A1460 ( 4.1A)
6NA  A1460 (-3.3A)
6NA  A1460 (-3.7A)
 0.30A 4ls7A-2iwzA:
66.0		 4ls7A-2iwzA:
49.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		7 / 12 GLY A 153
ALA A 208
SER A 244
PHE A 248
THR A 350
LEU A 387
PHE A 447
 6NA  A1460 (-3.5A)
6NA  A1460 (-3.4A)
None
6NA  A1460 (-4.9A)
None
6NA  A1460 ( 4.1A)
6NA  A1460 (-3.7A)
 0.63A 4ls7A-2iwzA:
66.0		 4ls7A-2iwzA:
49.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		7 / 12 GLY A 388
ALA A 208
CYH A 209
PHE A 248
LEU A 387
GLY A 446
PHE A 447
 None
6NA  A1460 (-3.4A)
6NA  A1460 (-1.7A)
6NA  A1460 (-4.9A)
6NA  A1460 ( 4.1A)
6NA  A1460 (-3.3A)
6NA  A1460 (-3.7A)
 1.42A 4ls7A-2iwzA:
66.0		 4ls7A-2iwzA:
49.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		9 / 12 ALA A 208
CYH A 209
PHE A 248
HIS A 348
THR A 350
HIS A 385
LEU A 387
GLY A 446
PHE A 447
 6NA  A1460 (-3.4A)
6NA  A1460 (-1.7A)
6NA  A1460 (-4.9A)
None
None
None
6NA  A1460 ( 4.1A)
6NA  A1460 (-3.3A)
6NA  A1460 (-3.7A)
 0.34A 4ls7A-2iwzA:
66.0
4ls7B-2iwzA:
66.0		 4ls7A-2iwzA:
49.32
4ls7B-2iwzA:
49.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		7 / 12 ALA A 208
SER A 244
PHE A 248
THR A 350
HIS A 385
LEU A 387
PHE A 447
 6NA  A1460 (-3.4A)
None
6NA  A1460 (-4.9A)
None
None
6NA  A1460 ( 4.1A)
6NA  A1460 (-3.7A)
 0.63A 4ls7A-2iwzA:
66.0
4ls7B-2iwzA:
66.0		 4ls7A-2iwzA:
49.32
4ls7B-2iwzA:
49.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 5 ALA A 396
THR A 399
VAL A 302
ILE A 456
 None
 0.79A 4xe3A-2iwzA:
undetectable		 4xe3A-2iwzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 5 ALA A 396
THR A 399
VAL A 302
ILE A 456
 None
 0.86A 4xe3B-2iwzA:
undetectable		 4xe3B-2iwzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLN A 430
LEU A 422
GLU A 431
ALA A 373
PHE A 438
 None
 1.24A 4xe5A-2iwzA:
undetectable		 4xe5A-2iwzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		6 / 9 LEU A 454
ALA A 213
ALA A 215
ALA A 233
LEU A 285
ALA A 395
 None
 1.23A 4z91F-2iwzA:
undetectable
4z91G-2iwzA:
undetectable
4z91H-2iwzA:
undetectable
4z91I-2iwzA:
undetectable
4z91J-2iwzA:
undetectable		 4z91F-2iwzA:
20.96
4z91G-2iwzA:
20.96
4z91H-2iwzA:
20.96
4z91I-2iwzA:
20.96
4z91J-2iwzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 11 THR A 207
SER A 444
ALA A 331
GLU A 394
GLY A 234
 None
NH4  A1461 ( 4.4A)
None
NH4  A1461 (-3.7A)
None
 1.14A 4zjoD-2iwzA:
undetectable		 4zjoD-2iwzA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A 300
ILE A 456
GLY A  48
LEU A 283
ALA A 395
 None
 1.32A 5ajqB-2iwzA:
undetectable		 5ajqB-2iwzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A  58
GLY A  50
LEU A  51
LEU A 400
TYR A 299
 None
 1.35A 5hwkA-2iwzA:
undetectable		 5hwkA-2iwzA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A  58
GLY A  50
LEU A  51
LEU A 400
TYR A 299
 None
 1.36A 5hwkB-2iwzA:
undetectable		 5hwkB-2iwzA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A  52
SER A 117
MET A 187
 None
 0.91A 5ikqA-2iwzA:
undetectable		 5ikqA-2iwzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 6 SER A 117
GLY A 279
MET A 121
ILE A 240
 None
 1.04A 5j4nA-2iwzA:
undetectable		 5j4nA-2iwzA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		6 / 12 GLY A 217
ILE A 223
ALA A 233
GLY A 234
HIS A 203
ALA A 149
 None
 1.11A 5kb6A-2iwzA:
undetectable		 5kb6A-2iwzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		6 / 12 GLY A 217
ILE A 223
ALA A 233
GLY A 234
HIS A 203
ALA A 149
 None
 1.09A 5kb6B-2iwzA:
undetectable		 5kb6B-2iwzA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 235
GLY A 212
THR A 119
ALA A 233
ALA A 189
 None
 0.87A 5kpcA-2iwzA:
undetectable		 5kpcA-2iwzA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 331
VAL A 216
ASN A 443
GLY A 391
ALA A 392
 None
 0.93A 5xxiA-2iwzA:
undetectable		 5xxiA-2iwzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE
(Homo
sapiens) 		4 / 6 THR A 399
LEU A 400
THR A 442
LEU A 407
 None
None
NH4  A1461 (-4.0A)
None
 1.18A 6mvxA-2iwzA:
undetectable
6mvxB-2iwzA:
undetectable
6mvxC-2iwzA:
undetectable		 6mvxA-2iwzA:
20.42
6mvxB-2iwzA:
20.42
6mvxC-2iwzA:
20.42