SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ix2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		4 / 6 ALA A 235
PHE A  15
ILE A  52
VAL A  56
 None
 0.87A 2cizA-2ix2A:
undetectable		 2cizA-2ix2A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		5 / 9 GLY A 224
SER A 198
ILE A 166
VAL A 221
VAL A 209
 None
 1.34A 2nnhB-2ix2A:
undetectable		 2nnhB-2ix2A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		3 / 3 LEU A 227
PRO A 228
LEU A 132
 None
 0.59A 2po5B-2ix2A:
undetectable		 2po5B-2ix2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		5 / 7 MET A 157
TYR A 177
ALA A 147
THR A 138
LEU A 181
 None
 1.44A 2wx2A-2ix2A:
undetectable		 2wx2A-2ix2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		4 / 8 ILE A 168
VAL A 153
SER A 141
TYR A 177
 None
 0.93A 2yoeB-2ix2A:
undetectable
2yoeC-2ix2A:
undetectable		 2yoeB-2ix2A:
20.77
2yoeC-2ix2A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		5 / 12 VAL A  56
ASP A  55
LEU A  28
SER A 237
PHE A  15
 None
 1.31A 3j6pB-2ix2A:
undetectable		 3j6pB-2ix2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		4 / 5 PHE A  12
THR A  92
PHE A  30
ILE A  89
 None
 1.26A 4jx1E-2ix2A:
undetectable		 4jx1E-2ix2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		5 / 11 VAL A  72
ILE A  89
ILE A 100
TYR A   6
LEU A  28
 None
 1.00A 5e4dB-2ix2A:
undetectable		 5e4dB-2ix2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		5 / 12 VAL A  56
ASP A  55
LEU A  28
SER A 237
PHE A  15
 None
 1.38A 5hnzB-2ix2A:
undetectable		 5hnzB-2ix2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		3 / 3 LYS A 116
LEU A  28
ILE A 100
 None
 0.67A 5kc0A-2ix2A:
undetectable		 5kc0A-2ix2A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		3 / 3 PHE A 243
ASP A 232
LEU A 227
 None
 0.57A 5uhbC-2ix2A:
undetectable		 5uhbC-2ix2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		3 / 3 PHE A 243
ASP A 232
LEU A 227
 None
 0.56A 5uhcC-2ix2A:
undetectable		 5uhcC-2ix2A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2ix2 DNA POLYMERASE
SLIDING CLAMP B
(Sulfolobus
solfataricus) 		5 / 12 ASN A 135
ILE A 231
VAL A 233
ILE A 159
VAL A 209
 None
 1.45A 6j21A-2ix2A:
undetectable		 6j21A-2ix2A:
17.97