SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ix5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 VAL A 265
VAL A 263
TRP A 197
 None
 0.88A 1bdwA-2ix5A:
undetectable
1bdwB-2ix5A:
undetectable		 1bdwA-2ix5A:
3.28
1bdwB-2ix5A:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1427_0
(FPRA)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 4 HIS A  90
PRO A  93
LYS A  94
ILE A  91
 None
 1.24A 1lquA-2ix5A:
0.0		 1lquA-2ix5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 8 ALA A 366
LEU A 363
GLY A 359
GLY A 419
 None
 0.81A 1rukH-2ix5A:
undetectable
1rukL-2ix5A:
undetectable		 1rukH-2ix5A:
20.28
1rukL-2ix5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		5 / 12 MET A 300
LEU A 342
VAL A 337
ARG A  63
LEU A  54
 None
 1.36A 1wsvA-2ix5A:
undetectable		 1wsvA-2ix5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		5 / 12 ALA A 101
LEU A 166
ALA A 164
VAL A  74
CYH A  69
 None
 1.01A 1xdkA-2ix5A:
undetectable		 1xdkA-2ix5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		5 / 12 ALA A 101
LEU A 166
ALA A 164
VAL A  74
CYH A  69
 None
 1.01A 1xdkE-2ix5A:
undetectable		 1xdkE-2ix5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		5 / 12 LEU A 393
LEU A 401
ALA A 376
MET A 333
CYH A 306
 None
 1.34A 1ya3A-2ix5A:
undetectable		 1ya3A-2ix5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 ASP A 213
ASP A 235
ASN A 208
 None
 0.57A 2bm9D-2ix5A:
undetectable		 2bm9D-2ix5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 THR A 224
ASP A 279
SER A 281
 None
None
CAA  A1432 ( 4.7A)
 0.57A 2nxeA-2ix5A:
undetectable		 2nxeA-2ix5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 THR A 224
ASP A 279
SER A 281
 None
None
CAA  A1432 ( 4.7A)
 0.62A 2nxeB-2ix5A:
undetectable		 2nxeB-2ix5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		5 / 12 THR A 224
ALA A 190
THR A 280
VAL A 274
GLY A 273
 None
 1.10A 2ve3A-2ix5A:
0.0		 2ve3A-2ix5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		5 / 12 THR A 224
ALA A 190
THR A 280
VAL A 274
GLY A 273
 None
 1.08A 2ve3B-2ix5A:
1.0		 2ve3B-2ix5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 7 GLY A  96
PHE A 135
HIS A 139
ILE A 136
 None
 0.86A 2y7wC-2ix5A:
undetectable		 2y7wC-2ix5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 8 LEU A  95
ILE A 136
HIS A 139
GLY A 102
 None
 0.95A 3b9lA-2ix5A:
2.0		 3b9lA-2ix5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 8 LEU A  95
ILE A 136
HIS A 139
GLY A 103
 None
 0.94A 3b9lA-2ix5A:
2.0		 3b9lA-2ix5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 8 THR A  92
LEU A  95
ALA A 101
HIS A 139
 None
 0.91A 3kp6A-2ix5A:
0.7		 3kp6A-2ix5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 GLY A 229
TRP A 197
VAL A 265
 None
 0.74A 3n62B-2ix5A:
undetectable		 3n62B-2ix5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 GLY A 229
TRP A 197
VAL A 265
 None
 0.71A 3n65B-2ix5A:
undetectable		 3n65B-2ix5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 GLY A 229
TRP A 197
VAL A 265
 None
 0.73A 3n66B-2ix5A:
undetectable		 3n66B-2ix5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 TYR A 405
MET A 343
LEU A 363
 None
 0.94A 3vw1D-2ix5A:
2.1		 3vw1D-2ix5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 8 VAL A 100
HIS A 139
ILE A 136
ALA A 170
 None
 0.98A 4eyzA-2ix5A:
undetectable		 4eyzA-2ix5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 8 VAL A 100
HIS A 139
ILE A 136
ALA A 170
 None
 0.98A 4eyzB-2ix5A:
undetectable		 4eyzB-2ix5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 5 LEU A 250
GLY A 249
ILE A 298
GLN A 294
 FAD  A1433 ( 4.6A)
None
None
None
 1.09A 4ma8C-2ix5A:
1.2		 4ma8C-2ix5A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		5 / 11 LEU A 284
LEU A 174
THR A 188
VAL A 274
ILE A 227
 CAA  A1432 (-4.2A)
FAD  A1433 (-4.4A)
None
None
None
 1.06A 4x20D-2ix5A:
undetectable		 4x20D-2ix5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		4 / 5 GLY A 301
ARG A 127
GLY A 297
GLU A 124
 None
 1.27A 4z2eB-2ix5A:
1.3
4z2eC-2ix5A:
undetectable		 4z2eB-2ix5A:
22.57
4z2eC-2ix5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL
(Arabidopsis
thaliana) 		3 / 3 GLY A 229
TRP A 197
VAL A 265
 None
 0.73A 5vuoB-2ix5A:
undetectable		 5vuoB-2ix5A:
21.67