SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ix8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1209
ILE A1205
ALA A1196
ILE A1171
PHE A1234
 None
 1.15A 1bsxA-2ix8A:
undetectable		 1bsxA-2ix8A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1209
ILE A1205
ALA A1196
ILE A1171
PHE A1234
 None
 1.15A 1bsxB-2ix8A:
undetectable		 1bsxB-2ix8A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 GLY A1762
ASP A1764
GLY A1909
TYR A1734
 None
 0.75A 1eswA-2ix8A:
undetectable		 1eswA-2ix8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 5 ILE A1372
ARG A1375
ASP A1278
ASN A1321
 None
 1.20A 1kiaD-2ix8A:
1.0		 1kiaD-2ix8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		3 / 3 PHE A1688
TRP A1963
GLU A1961
 None
 1.19A 1mogA-2ix8A:
undetectable		 1mogA-2ix8A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 4 ILE A1372
ARG A1375
ASP A1278
ASN A1321
 None
 1.24A 1nbiC-2ix8A:
1.9		 1nbiC-2ix8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 4 ILE A1372
ARG A1375
ASP A1278
ASN A1321
 None
 1.26A 1nbiD-2ix8A:
2.1		 1nbiD-2ix8A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 PHE A1435
SER A1436
LEU A1437
THR A1448
 None
 0.66A 1sbrA-2ix8A:
undetectable		 1sbrA-2ix8A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1313
ALA A1266
ILE A1269
GLY A1292
 None
 0.83A 1sv9A-2ix8A:
undetectable		 1sv9A-2ix8A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 7 ALA A1474
TYR A1493
ILE A1475
ILE A1593
ASP A1567
 None
 1.37A 1upfB-2ix8A:
undetectable		 1upfB-2ix8A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 LYS A1616
LEU A1617
GLN A1449
LEU A1471
 None
 1.00A 1v55P-2ix8A:
undetectable
1v55W-2ix8A:
undetectable		 1v55P-2ix8A:
12.63
1v55W-2ix8A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 LYS A1616
LEU A1617
GLN A1449
LEU A1471
 None
 1.01A 2dysC-2ix8A:
undetectable
2dysJ-2ix8A:
undetectable		 2dysC-2ix8A:
12.63
2dysJ-2ix8A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 LYS A1616
LEU A1617
GLN A1449
LEU A1471
 None
 0.95A 2eijC-2ix8A:
undetectable
2eijJ-2ix8A:
undetectable		 2eijC-2ix8A:
12.63
2eijJ-2ix8A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1208
LEU A1229
VAL A1226
VAL A1267
LEU A1254
 None
 1.27A 2hc4A-2ix8A:
undetectable		 2hc4A-2ix8A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1208
VAL A1226
SER A1891
VAL A1267
LEU A1254
 None
 1.29A 2hc4A-2ix8A:
undetectable		 2hc4A-2ix8A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		3 / 3 ALA A1733
GLY A1943
SER A1863
 None
 0.59A 2ivuA-2ix8A:
undetectable		 2ivuA-2ix8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 5 ALA A1098
ALA A1150
GLN A1143
VAL A1185
 None
 0.93A 2nyrB-2ix8A:
undetectable		 2nyrB-2ix8A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1731
GLU A1859
GLN A1865
 None
 1.00A 2p16A-2ix8A:
undetectable		 2p16A-2ix8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 GLN A1900
ILE A1743
SER A1469
TYR A1439
 None
 1.41A 2xz5D-2ix8A:
undetectable
2xz5E-2ix8A:
undetectable		 2xz5D-2ix8A:
11.20
2xz5E-2ix8A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 HIS A1877
LEU A1881
ALA A1937
PRO A1650
 None
 1.33A 3gv1A-2ix8A:
undetectable
3gv1C-2ix8A:
undetectable		 3gv1A-2ix8A:
9.78
3gv1C-2ix8A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1229
LEU A1228
GLU A1224
GLY A1253
LEU A1249
 None
 1.32A 3hm1B-2ix8A:
undetectable		 3hm1B-2ix8A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1222
VAL A1226
LEU A1229
VAL A1267
 None
 0.45A 3hs6B-2ix8A:
undetectable		 3hs6B-2ix8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		3 / 3 ASN A1571
ASP A1567
ARG A1758
 None
 0.94A 3k13C-2ix8A:
undetectable		 3k13C-2ix8A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 VAL A1120
ILE A1057
ALA A1074
LEU A1079
 None
 0.92A 3kk6B-2ix8A:
undetectable		 3kk6B-2ix8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		3 / 3 VAL A1698
VAL A1965
TRP A1963
 None
 0.82A 3l8lA-2ix8A:
undetectable
3l8lB-2ix8A:
undetectable		 3l8lA-2ix8A:
2.19
3l8lB-2ix8A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1673
TYR A1675
THR A1708
VAL A1712
 None
 1.19A 3lb3A-2ix8A:
undetectable		 3lb3A-2ix8A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1673
TYR A1675
THR A1708
VAL A1712
 None
 1.24A 3lb3B-2ix8A:
undetectable		 3lb3B-2ix8A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 9 ILE A1282
LEU A1290
ARG A1252
LEU A1249
GLY A1292
 None
 1.50A 3nxuB-2ix8A:
undetectable		 3nxuB-2ix8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1551
ILE A1536
VAL A1507
LEU A1508
PHE A1510
 None
 1.18A 3w68A-2ix8A:
undetectable		 3w68A-2ix8A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 THR A1133
ASN A1134
CYH A1095
ILE A1116
 None
 0.91A 3w9tB-2ix8A:
undetectable		 3w9tB-2ix8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 THR A1133
ASN A1134
CYH A1095
ILE A1116
 None
 0.91A 3w9tF-2ix8A:
undetectable		 3w9tF-2ix8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1291
GLY A1292
ASN A1296
LEU A1254
 None
 0.89A 3zqtA-2ix8A:
undetectable		 3zqtA-2ix8A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 LEU A1581
VAL A1605
TYR A1584
LEU A1566
 None
 1.16A 4b3qA-2ix8A:
undetectable		 4b3qA-2ix8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1222
VAL A1226
LEU A1229
MET A1272
 None
 1.02A 4e1gB-2ix8A:
undetectable		 4e1gB-2ix8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1222
VAL A1226
LEU A1229
VAL A1267
 None
 0.42A 4e1gB-2ix8A:
undetectable		 4e1gB-2ix8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 ILE A1710
ASN A1711
GLU A1766
VAL A1905
 None
 1.06A 4ejwB-2ix8A:
undetectable		 4ejwB-2ix8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 ASN A1075
VAL A1070
ILE A1087
SER A1115
 None
 0.98A 4eyzA-2ix8A:
undetectable		 4eyzA-2ix8A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 ASN A1075
VAL A1070
ILE A1087
SER A1115
 None
 0.98A 4eyzB-2ix8A:
undetectable		 4eyzB-2ix8A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 11 HIS A1746
ILE A1893
GLY A1898
GLY A1899
ASN A1464
 None
 1.47A 4fglA-2ix8A:
undetectable
4fglB-2ix8A:
undetectable		 4fglA-2ix8A:
13.68
4fglB-2ix8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 MET A1880
PHE A1647
PHE A1954
GLY A1909
LEU A1919
 None
 1.22A 4kykA-2ix8A:
undetectable
4kykB-2ix8A:
undetectable		 4kykA-2ix8A:
11.72
4kykB-2ix8A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 4 ASN A1702
GLY A1545
ASP A1927
ASP A1920
 None
 1.37A 4n49A-2ix8A:
undetectable		 4n49A-2ix8A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1581
VAL A1605
TYR A1584
LEU A1566
 None
 0.98A 4puoC-2ix8A:
2.1		 4puoC-2ix8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 GLU A1221
THR A1225
LEU A1228
GLN A1214
 None
 1.03A 4qztA-2ix8A:
undetectable		 4qztA-2ix8A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1430
ARG A1454
THR A1591
LEU A1564
ILE A1563
 None
 1.36A 4ubsA-2ix8A:
undetectable		 4ubsA-2ix8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 8 ALA A1312
ALA A1266
ILE A1269
ALA A1231
PHE A1234
 None
 1.44A 4v1fA-2ix8A:
undetectable
4v1fB-2ix8A:
undetectable		 4v1fA-2ix8A:
6.59
4v1fB-2ix8A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 LYS A1616
LEU A1617
GLN A1449
LEU A1471
 None
 0.84A 5b3sP-2ix8A:
undetectable		 5b3sP-2ix8A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 7 LYS A1903
GLY A1467
SER A1897
LEU A1896
 None
 1.11A 5bphB-2ix8A:
undetectable		 5bphB-2ix8A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 PRO A1719
ILE A1732
VAL A1668
VAL A1724
LEU A1916
 None
 1.17A 5bykA-2ix8A:
undetectable		 5bykA-2ix8A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 9 ASP A1201
ALA A1236
VAL A1235
LYS A1447
GLU A1434
 None
 1.33A 5dbyA-2ix8A:
3.4		 5dbyA-2ix8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 MET A1390
LEU A1341
ARG A1166
LEU A1348
 None
 1.07A 5dxeA-2ix8A:
undetectable		 5dxeA-2ix8A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1655
CYH A1690
HIS A1915
LEU A1916
 None
 1.04A 5hrqD-2ix8A:
undetectable
5hrqG-2ix8A:
undetectable
5hrqH-2ix8A:
undetectable		 5hrqD-2ix8A:
3.39
5hrqG-2ix8A:
2.02
5hrqH-2ix8A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1655
CYH A1690
HIS A1915
LEU A1916
 None
 1.25A 5hrqD-2ix8A:
undetectable
5hrqG-2ix8A:
undetectable
5hrqH-2ix8A:
undetectable		 5hrqD-2ix8A:
3.39
5hrqG-2ix8A:
2.02
5hrqH-2ix8A:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1907
TRP A1757
TYR A1754
ALA A1908
GLY A1909
 None
 1.17A 5tzoA-2ix8A:
undetectable		 5tzoA-2ix8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1907
TRP A1757
TYR A1754
ALA A1908
GLY A1909
 None
 1.19A 5tzoB-2ix8A:
undetectable		 5tzoB-2ix8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1907
TRP A1757
TYR A1754
ALA A1908
GLY A1909
 None
 1.16A 5tzoC-2ix8A:
undetectable		 5tzoC-2ix8A:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 LYS A1061
PHE A1014
SER A1018
GLY A1056
 None
 1.01A 5v0vA-2ix8A:
2.9		 5v0vA-2ix8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 PRO A1719
LEU A1718
VAL A1668
VAL A1724
LEU A1916
 None
 1.23A 6b52A-2ix8A:
undetectable		 6b52A-2ix8A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 MET A1390
LEU A1341
ARG A1166
LEU A1348
 None
 1.07A 6cbzA-2ix8A:
undetectable		 6cbzA-2ix8A:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 8 GLY A1943
LEU A1692
GLN A1662
VAL A1666
 None
 0.70A 6czmD-2ix8A:
undetectable
6czmF-2ix8A:
undetectable		 6czmD-2ix8A:
16.50
6czmF-2ix8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		4 / 6 GLN A1865
GLU A1859
HIS A1915
GLN A1912
 None
 1.12A 6f6jC-2ix8A:
undetectable
6f6jD-2ix8A:
undetectable		 6f6jC-2ix8A:
15.83
6f6jD-2ix8A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2ix8 ELONGATION FACTOR 3A
(Saccharomyces
cerevisiae) 		5 / 12 ASN A1037
ILE A1116
VAL A1120
VAL A1091
PHE A1050
 None
 1.40A 6j21A-2ix8A:
undetectable		 6j21A-2ix8A:
18.62