SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 ALA A  60
SER A 177
GLN A 178
GLU A  56
ASP A  15
 None
None
None
None
ZN  A1234 ( 2.1A)
 0.99A 1dy4A-2ixdA:
undetectable		 1dy4A-2ixdA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 5 THR A  40
ASP A 112
HIS A 110
HIS A  12
 None
None
ACT  A1235 ( 4.6A)
ZN  A1234 ( 3.1A)
 1.21A 1ei6A-2ixdA:
undetectable		 1ei6A-2ixdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 7 VAL A  92
VAL A 101
TYR A 105
ARG A  87
 None
 1.31A 1t46A-2ixdA:
undetectable		 1t46A-2ixdA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 11 VAL A 198
GLU A  17
ARG A 201
GLU A 215
ILE A 149
 None
 1.07A 1t6zA-2ixdA:
4.2		 1t6zA-2ixdA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 GLY A 128
ALA A 127
ILE A  89
ILE A  86
ILE A  93
 None
 0.92A 2b60A-2ixdA:
undetectable		 2b60A-2ixdA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		3 / 3 ASP A  43
THR A 188
PRO A 189
 None
 0.72A 2pynB-2ixdA:
undetectable		 2pynB-2ixdA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A 113
ILE A  18
ASP A  14
ARG A  53
 ZN  A1234 ( 3.2A)
None
ACT  A1235 (-2.8A)
ACT  A1235 (-4.6A)
 1.07A 2v57A-2ixdA:
undetectable		 2v57A-2ixdA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A 113
ILE A  18
ASP A  14
ARG A  53
 ZN  A1234 ( 3.2A)
None
ACT  A1235 (-2.8A)
ACT  A1235 (-4.6A)
 1.06A 2v57C-2ixdA:
undetectable		 2v57C-2ixdA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ARG A  53
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
ACT  A1235 (-4.6A)
ACT  A1235 ( 4.6A)
None
 0.82A 2xadA-2ixdA:
20.3		 2xadA-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ASP A  76
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
None
ACT  A1235 ( 4.6A)
None
 0.22A 2xadA-2ixdA:
20.3		 2xadA-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ARG A  53
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
ACT  A1235 (-4.6A)
ACT  A1235 ( 4.6A)
None
 0.81A 2xadB-2ixdA:
20.1		 2xadB-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ASP A  76
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
None
ACT  A1235 ( 4.6A)
None
 0.26A 2xadB-2ixdA:
20.1		 2xadB-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ARG A  53
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
ACT  A1235 (-4.6A)
ACT  A1235 ( 4.6A)
None
 0.83A 2xadC-2ixdA:
20.4		 2xadC-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ASP A  76
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
None
ACT  A1235 ( 4.6A)
None
 0.26A 2xadC-2ixdA:
20.4		 2xadC-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ARG A  53
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
ACT  A1235 (-4.6A)
ACT  A1235 ( 4.6A)
None
 0.84A 2xadD-2ixdA:
20.3		 2xadD-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 8 HIS A  12
ASP A  76
HIS A 110
ASP A 112
 ZN  A1234 ( 3.1A)
None
ACT  A1235 ( 4.6A)
None
 0.21A 2xadD-2ixdA:
20.3		 2xadD-2ixdA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 7 ALA A 127
LEU A 136
SER A 137
VAL A 141
 None
 0.84A 3d2tA-2ixdA:
undetectable		 3d2tA-2ixdA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 ALA A 127
LEU A 136
SER A 137
VAL A 141
 None
 0.79A 3d2tB-2ixdA:
undetectable		 3d2tB-2ixdA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 GLN A 178
HIS A 110
HIS A 113
ASP A  14
 None
ACT  A1235 ( 4.6A)
ZN  A1234 ( 3.2A)
ACT  A1235 (-2.8A)
 1.16A 3nvcA-2ixdA:
undetectable		 3nvcA-2ixdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 5 LYS A  26
THR A  23
ILE A 161
PHE A 217
 None
 1.37A 3tf1A-2ixdA:
undetectable		 3tf1A-2ixdA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A  39
ILE A  36
ILE A  89
ILE A 124
ALA A 103
 None
 1.26A 3uj7A-2ixdA:
undetectable		 3uj7A-2ixdA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 PHE A 217
TYR A  27
HIS A   5
VAL A  66
 None
 1.24A 4a97I-2ixdA:
undetectable		 4a97I-2ixdA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 6 ILE A  24
CYH A 116
LEU A  39
CYH A  37
 None
 0.89A 4asdA-2ixdA:
undetectable		 4asdA-2ixdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 7 TYR A 147
ILE A  18
PRO A 104
HIS A  12
 None
None
None
ZN  A1234 ( 3.1A)
 1.08A 4g5jA-2ixdA:
undetectable		 4g5jA-2ixdA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 7 LEU A  72
ARG A  69
PRO A 104
VAL A  16
 None
 1.25A 4klrA-2ixdA:
2.7		 4klrA-2ixdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		3 / 3 ILE A  18
MET A 218
ASP A 108
 None
 0.78A 5h2uA-2ixdA:
undetectable		 5h2uA-2ixdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 5 ILE A   6
LEU A  39
GLY A  10
PHE A   9
 None
 0.92A 5kmdC-2ixdA:
undetectable
5kmdD-2ixdA:
undetectable		 5kmdC-2ixdA:
21.57
5kmdD-2ixdA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 PHE A 205
GLY A 216
VAL A  16
LEU A 212
GLY A 206
 None
 0.89A 6c2mA-2ixdA:
undetectable		 6c2mA-2ixdA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		4 / 5 LEU A  70
THR A  68
CYH A  37
GLY A  35
 None
 1.21A 6gtqA-2ixdA:
undetectable		 6gtqA-2ixdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 190
HIS A 110
HIS A 113
ASP A  15
ASP A  14
 ACT  A1235 (-4.2A)
ACT  A1235 ( 4.6A)
ZN  A1234 ( 3.2A)
ZN  A1234 ( 2.1A)
ACT  A1235 (-2.8A)
 1.08A 6n91A-2ixdA:
undetectable		 6n91A-2ixdA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 190
SER A  46
HIS A 113
ASP A  15
ASP A  14
 ACT  A1235 (-4.2A)
None
ZN  A1234 ( 3.2A)
ZN  A1234 ( 2.1A)
ACT  A1235 (-2.8A)
 1.32A 6n91A-2ixdA:
undetectable		 6n91A-2ixdA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 190
HIS A 110
HIS A 113
ASP A  15
ASP A  14
 ACT  A1235 (-4.2A)
ACT  A1235 ( 4.6A)
ZN  A1234 ( 3.2A)
ZN  A1234 ( 2.1A)
ACT  A1235 (-2.8A)
 1.04A 6n91B-2ixdA:
undetectable		 6n91B-2ixdA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2ixd LMBE-RELATED PROTEIN
(Bacillus
cereus) 		5 / 12 LEU A 190
SER A  46
HIS A 113
ASP A  15
ASP A  14
 ACT  A1235 (-4.2A)
None
ZN  A1234 ( 3.2A)
ZN  A1234 ( 2.1A)
ACT  A1235 (-2.8A)
 1.30A 6n91B-2ixdA:
undetectable		 6n91B-2ixdA:
14.92