SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		4 / 8 MET A 476
GLN A 557
PRO A 473
ARG A 636
 None
 1.20A 1dtlA-2ixfA:
undetectable		 1dtlA-2ixfA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 7 ALA A 577
ILE A 589
ILE A 602
ASP A 610
PHE A 572
 GOL  A   3 (-3.2A)
GOL  A   3 ( 4.8A)
None
None
None
 1.42A 1upfB-2ixfA:
undetectable		 1upfB-2ixfA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 12 LEU A 546
HIS A 555
ALA A 472
GLY A 469
SER A 468
 None
 1.15A 2a58A-2ixfA:
undetectable
2a58B-2ixfA:
undetectable		 2a58A-2ixfA:
19.93
2a58B-2ixfA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 12 LEU A 546
HIS A 555
ALA A 472
GLY A 469
SER A 468
 None
 1.15A 2a58B-2ixfA:
undetectable
2a58C-2ixfA:
undetectable		 2a58B-2ixfA:
19.93
2a58C-2ixfA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 12 LEU A 546
HIS A 555
ALA A 472
GLY A 469
SER A 468
 None
 1.15A 2a58D-2ixfA:
undetectable
2a58E-2ixfA:
undetectable		 2a58D-2ixfA:
19.93
2a58E-2ixfA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 12 VAL A 658
ARG A 660
LEU A 630
ILE A 602
PHE A 601
 None
 1.19A 3mnoA-2ixfA:
undetectable		 3mnoA-2ixfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 12 VAL A 658
ARG A 660
LEU A 630
ILE A 602
PHE A 601
 None
 1.20A 3mnpA-2ixfA:
undetectable		 3mnpA-2ixfA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 8 PHE A 482
PHE A 503
ALA A 525
LEU A 640
LEU A 505
 None
 1.07A 4ejgB-2ixfA:
undetectable		 4ejgB-2ixfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 7 PHE A 482
PHE A 503
ALA A 525
LEU A 640
LEU A 505
 None
 1.05A 4ejgC-2ixfA:
undetectable		 4ejgC-2ixfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		4 / 6 PHE A 482
PHE A 503
ALA A 525
LEU A 640
 None
 1.03A 4ejgD-2ixfA:
undetectable		 4ejgD-2ixfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		4 / 5 LYS A 637
LEU A 634
GLU A 667
LEU A 661
 None
 1.22A 4k4yA-2ixfA:
undetectable		 4k4yA-2ixfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		4 / 4 LYS A 637
LEU A 634
GLU A 667
LEU A 661
 None
 1.21A 4k4yE-2ixfA:
undetectable		 4k4yE-2ixfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		4 / 5 LYS A 637
LEU A 634
GLU A 667
LEU A 661
 None
 1.23A 4k4yI-2ixfA:
undetectable		 4k4yI-2ixfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 9 TYR A 506
THR A 672
GLY A 478
LEU A 640
VAL A 558
 None
 1.11A 4mjrA-2ixfA:
undetectable		 4mjrA-2ixfA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		6 / 11 ALA A 631
LEU A 630
LEU A 643
LEU A 641
ARG A 671
LEU A 662
 None
 1.45A 4wg0C-2ixfA:
undetectable
4wg0D-2ixfA:
undetectable
4wg0E-2ixfA:
undetectable		 4wg0C-2ixfA:
4.18
4wg0D-2ixfA:
4.18
4wg0E-2ixfA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 10 GLY A 562
VAL A 561
THR A 647
LEU A 650
LEU A 641
 None
 1.31A 4yb6C-2ixfA:
undetectable
4yb6F-2ixfA:
undetectable		 4yb6C-2ixfA:
24.01
4yb6F-2ixfA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 10 LEU A 650
LEU A 641
GLY A 562
VAL A 561
THR A 647
 None
 1.29A 4yb6A-2ixfA:
undetectable
4yb6D-2ixfA:
undetectable		 4yb6A-2ixfA:
24.01
4yb6D-2ixfA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		4 / 8 LEU A 531
LEU A 528
HIS A 555
LEU A 554
 None
 1.08A 5dxeA-2ixfA:
undetectable		 5dxeA-2ixfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		5 / 12 GLY A 623
VAL A 658
VAL A 628
ALA A 629
LEU A 630
 None
 0.98A 5kocA-2ixfA:
undetectable		 5kocA-2ixfA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2ixf ANTIGEN PEPTIDE
TRANSPORTER 1
(Rattus
norvegicus) 		4 / 8 LEU A 531
LEU A 528
HIS A 555
LEU A 554
 None
 1.07A 6cbzA-2ixfA:
undetectable		 6cbzA-2ixfA:
17.25