SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ixl DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Streptococcus
suis) 		4 / 5 TRP A 168
ILE A 166
LEU A 171
ALA A 160
 None
 0.96A 1xvaA-2ixlA:
undetectable
1xvaB-2ixlA:
undetectable		 1xvaA-2ixlA:
21.00
1xvaB-2ixlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2ixl DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Streptococcus
suis) 		4 / 6 ALA A 160
TRP A 168
ILE A 166
LEU A 171
 None
 1.04A 1xvaA-2ixlA:
undetectable
1xvaB-2ixlA:
undetectable		 1xvaA-2ixlA:
21.00
1xvaB-2ixlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2ixl DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Streptococcus
suis) 		4 / 7 GLY A 128
ASP A  98
LEU A  99
ARG A 100
 TRH  A1198 ( 4.1A)
None
None
None
 0.63A 2uyqA-2ixlA:
undetectable		 2uyqA-2ixlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2ixl DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Streptococcus
suis) 		4 / 6 LEU A  93
GLY A 128
LEU A 132
SER A 133
 None
TRH  A1198 ( 4.1A)
None
None
 0.89A 3aiaA-2ixlA:
undetectable		 3aiaA-2ixlA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2ixl DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Streptococcus
suis) 		5 / 12 PHE A   5
GLY A  34
ASN A  32
GLY A  30
PHE A   6
 None
 1.21A 3ps9A-2ixlA:
undetectable		 3ps9A-2ixlA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2ixl DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE
(Streptococcus
suis) 		3 / 3 PHE A 129
SER A  65
SER A  67
 None
TRH  A1198 ( 4.9A)
None
 0.98A 3ufgB-2ixlA:
undetectable		 3ufgB-2ixlA:
21.73