SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		4 / 8 PHE A 159
LEU A 119
LEU A  81
LEU A 112
 None
 0.89A 1eupA-2ixmA:
undetectable		 1eupA-2ixmA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		4 / 8 LEU A  81
TYR A 188
LEU A 163
SER A 142
 None
 1.23A 1hk2A-2ixmA:
2.4		 1hk2A-2ixmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		4 / 8 LEU A 119
LEU A  81
TYR A 188
LEU A 163
 None
 1.22A 1hk2A-2ixmA:
2.4		 1hk2A-2ixmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		4 / 6 LEU A 139
LEU A 119
LEU A  81
LEU A 163
 None
 1.02A 2ab2A-2ixmA:
undetectable		 2ab2A-2ixmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 12 THR A 153
ALA A 160
PHE A 185
ILE A 221
TYR A  45
 None
 1.20A 2nyrA-2ixmA:
undetectable		 2nyrA-2ixmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		4 / 4 LYS A 183
LEU A  78
ALA A 179
LEU A  77
 None
 1.46A 2roxA-2ixmA:
undetectable		 2roxA-2ixmA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 12 LEU A  80
LEU A  81
LEU A 189
ARG A 193
LEU A 163
 None
 1.27A 3d90B-2ixmA:
undetectable		 3d90B-2ixmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 10 GLU A 301
LEU A 300
ILE A  52
LEU A 218
ILE A 292
 None
 1.17A 3jw3A-2ixmA:
undetectable		 3jw3A-2ixmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		3 / 3 SER A 224
SER A 225
HIS A 230
 None
 0.75A 3mzeA-2ixmA:
undetectable		 3mzeA-2ixmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 10 PHE A 238
VAL A 244
PHE A 253
ILE A 260
PHE A 268
 None
 1.41A 3t3qB-2ixmA:
undetectable		 3t3qB-2ixmA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 10 PHE A 238
VAL A 244
PHE A 253
ILE A 260
PHE A 268
 None
 1.44A 3t3qC-2ixmA:
undetectable		 3t3qC-2ixmA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 10 PHE A 238
VAL A 244
PHE A 253
ILE A 260
PHE A 268
 None
 1.43A 3t3qD-2ixmA:
undetectable		 3t3qD-2ixmA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 12 ILE A 180
PHE A 185
LEU A  55
TYR A  48
ILE A  49
 None
 1.01A 4g1bD-2ixmA:
undetectable		 4g1bD-2ixmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		4 / 8 LEU A  80
LEU A 112
THR A  83
LEU A  84
 None
 0.68A 4z90F-2ixmA:
undetectable
4z90G-2ixmA:
undetectable
4z90H-2ixmA:
undetectable
4z90I-2ixmA:
undetectable
4z90J-2ixmA:
undetectable		 4z90F-2ixmA:
19.58
4z90G-2ixmA:
19.58
4z90H-2ixmA:
19.58
4z90I-2ixmA:
19.58
4z90J-2ixmA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 11 GLY A 223
ILE A 228
ASN A 288
ASP A 229
PRO A 235
 None
 1.31A 5hjiA-2ixmA:
undetectable		 5hjiA-2ixmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		3 / 3 LEU A 139
LEU A  84
ARG A 106
 None
 0.66A 5hnzB-2ixmA:
undetectable		 5hnzB-2ixmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'
(Homo
sapiens) 		5 / 12 GLY A 152
GLY A 154
SER A 142
PHE A 217
TYR A 295
 None
 0.88A 5yf0A-2ixmA:
undetectable		 5yf0A-2ixmA:
23.47