SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 203
LEU A 163
SER A  35
 None
 0.94A 1e7aA-2ixnA:
undetectable		 1e7aA-2ixnA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 MET A  56
LEU A  59
SER A  60
 None
 0.63A 1ee2A-2ixnA:
undetectable		 1ee2A-2ixnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 123
HIS A 135
LEU A 176
LEU A 182
 None
 1.27A 1hz4A-2ixnA:
undetectable		 1hz4A-2ixnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 251
VAL A 190
TRP A 191
 None
 0.91A 1qw6A-2ixnA:
undetectable		 1qw6A-2ixnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 251
VAL A 190
TRP A 191
 None
 0.96A 1qwcA-2ixnA:
undetectable		 1qwcA-2ixnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 202
GLU A  34
THR A 209
ALA A 205
 None
 0.79A 1sn5C-2ixnA:
undetectable		 1sn5C-2ixnA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 251
VAL A 190
TRP A 191
 None
 0.99A 1vagA-2ixnA:
0.4		 1vagA-2ixnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 251
VAL A 190
TRP A 191
 None
 0.96A 1zviA-2ixnA:
undetectable		 1zviA-2ixnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		5 / 8 SER A  49
PHE A 152
LEU A 143
LEU A  59
LEU A  58
 None
 1.20A 2bfpB-2ixnA:
undetectable		 2bfpB-2ixnA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		5 / 8 SER A 106
PHE A 104
LEU A  58
LEU A 142
LEU A 143
 None
 1.37A 2bfpB-2ixnA:
undetectable		 2bfpB-2ixnA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 232
GLY A 236
PHE A 228
 None
 0.70A 2m2pB-2ixnA:
undetectable		 2m2pB-2ixnA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 7 TRP A  16
PHE A 291
SER A 283
VAL A 281
 None
 1.47A 3dqtA-2ixnA:
undetectable
3dqtB-2ixnA:
undetectable		 3dqtA-2ixnA:
20.27
3dqtB-2ixnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 7 SER A 283
VAL A 281
TRP A  16
PHE A 291
 None
 1.46A 3n5tA-2ixnA:
undetectable
3n5tB-2ixnA:
undetectable		 3n5tA-2ixnA:
20.17
3n5tB-2ixnA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 266
PRO A 216
LEU A 250
ILE A 260
 None
 0.95A 3u5jA-2ixnA:
undetectable		 3u5jA-2ixnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 233
GLY A 204
GLN A 207
ILE A 260
VAL A 263
 None
 1.36A 4okwA-2ixnA:
undetectable		 4okwA-2ixnA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 137
ASN A 138
LEU A 297
ILE A 117
 None
 1.01A 4okxA-2ixnA:
undetectable		 4okxA-2ixnA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 7 TRP A  16
PHE A 291
SER A 283
VAL A 281
 None
 1.44A 5adlA-2ixnA:
undetectable
5adlB-2ixnA:
undetectable		 5adlA-2ixnA:
20.21
5adlB-2ixnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 7 TRP A  16
PHE A 291
SER A 283
VAL A 281
 None
 1.45A 5fj3A-2ixnA:
undetectable
5fj3B-2ixnA:
undetectable		 5fj3A-2ixnA:
20.21
5fj3B-2ixnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 251
VAL A 190
TRP A 191
 None
 0.98A 5fvoA-2ixnA:
undetectable		 5fvoA-2ixnA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 257
VAL A 281
PHE A 166
GLY A 236
TYR A 234
 None
 1.07A 5uxdB-2ixnA:
undetectable		 5uxdB-2ixnA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 7 TRP A  16
PHE A 291
SER A 283
VAL A 281
 None
 1.45A 5vv7A-2ixnA:
undetectable
5vv7B-2ixnA:
undetectable		 5vv7A-2ixnA:
20.21
5vv7B-2ixnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		4 / 7 TRP A  16
PHE A 291
SER A 283
VAL A 281
 None
 1.42A 5vvnA-2ixnA:
undetectable
5vvnB-2ixnA:
undetectable		 5vvnA-2ixnA:
20.21
5vvnB-2ixnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 132
GLY A 134
SER A 122
PHE A 198
TYR A 277
 None
 0.93A 5yf0A-2ixnA:
undetectable		 5yf0A-2ixnA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 196
ARG A 174
THR A 178
 None
 0.97A 5z84J-2ixnA:
undetectable		 5z84J-2ixnA:
10.32