SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ixo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 160
ILE A  64
PRO A 166
MET A  71
ASN A  68
 None
 1.15A 1g60B-2ixoA:
undetectable		 1g60B-2ixoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 208
ARG A 185
ILE A 255
GLY A 251
 None
 0.97A 1oniA-2ixoA:
undetectable
1oniB-2ixoA:
undetectable		 1oniA-2ixoA:
17.63
1oniB-2ixoA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 208
ARG A 185
ILE A 255
GLY A 251
 None
 0.96A 1oniD-2ixoA:
undetectable
1oniF-2ixoA:
undetectable		 1oniD-2ixoA:
17.63
1oniF-2ixoA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  76
ILE A 183
THR A  84
 None
 0.76A 1rx3A-2ixoA:
undetectable		 1rx3A-2ixoA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  74
SER A 135
LEU A 176
LEU A  70
 None
 1.06A 1yajA-2ixoA:
undetectable		 1yajA-2ixoA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 258
LYS A 259
GLU A 194
PRO A 195
 None
 1.16A 3hs4A-2ixoA:
undetectable		 3hs4A-2ixoA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 141
ASP A 106
GLN A 129
 None
 0.91A 4azsA-2ixoA:
undetectable		 4azsA-2ixoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 304
SER A 138
ASP A 205
ASP A 143
 None
 1.40A 4blvA-2ixoA:
undetectable		 4blvA-2ixoA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 204
ASP A 205
GLY A 251
GLN A 218
ILE A 252
 None
 1.17A 4djeA-2ixoA:
undetectable		 4djeA-2ixoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 212
VAL A 239
PHE A 263
LEU A 270
 None
 1.03A 4f8hA-2ixoA:
undetectable
4f8hB-2ixoA:
undetectable		 4f8hA-2ixoA:
21.20
4f8hB-2ixoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 212
VAL A 239
PHE A 263
LEU A 270
 None
 1.01A 4f8hB-2ixoA:
undetectable
4f8hC-2ixoA:
undetectable		 4f8hB-2ixoA:
21.20
4f8hC-2ixoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 212
VAL A 239
PHE A 263
LEU A 270
 None
 1.03A 4f8hC-2ixoA:
undetectable
4f8hD-2ixoA:
undetectable		 4f8hC-2ixoA:
21.20
4f8hD-2ixoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 212
VAL A 239
PHE A 263
LEU A 270
 None
 1.03A 4f8hD-2ixoA:
undetectable
4f8hE-2ixoA:
undetectable		 4f8hD-2ixoA:
21.20
4f8hE-2ixoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 239
PHE A 263
LEU A 270
TYR A 212
 None
 1.02A 4f8hA-2ixoA:
undetectable
4f8hE-2ixoA:
undetectable		 4f8hA-2ixoA:
21.20
4f8hE-2ixoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  76
ILE A 183
THR A  84
 None
 0.72A 4gh8A-2ixoA:
undetectable		 4gh8A-2ixoA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 142
GLU A 100
LEU A 187
HIS A 148
 None
 1.36A 4xi3B-2ixoA:
undetectable		 4xi3B-2ixoA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 233
VAL A 283
TYR A 212
TRP A 280
 None
 0.98A 5jwaH-2ixoA:
undetectable		 5jwaH-2ixoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 193
ILE A 188
TYR A 180
 None
 0.66A 5uunB-2ixoA:
undetectable		 5uunB-2ixoA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 105
ASP A 106
GLN A 129
VAL A 211
 None
 1.20A 6bzoF-2ixoA:
undetectable		 6bzoF-2ixoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 144
HIS A 207
PHE A 208
 None
 0.96A 6esmA-2ixoA:
undetectable		 6esmA-2ixoA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 248
HIS A 209
PRO A  55
VAL A 295
GLY A 145
 None
 1.14A 6gngA-2ixoA:
undetectable		 6gngA-2ixoA:
19.16